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We are analyzing https://www.nature.com/articles/s41467-020-18841-7.

Title:
In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition | Nature Communications
Description:
The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which these core programs are distinct, overlapping, or identical has remained undefined. Here, we triggered partial EMT (pEMT) or UJT in differentiated primary human bronchial epithelial cells. After triggering UJT, cell-cell junctions, apico-basal polarity, and barrier function remain intact, cells elongate and align into cooperative migratory packs, and mesenchymal markers of EMT remain unapparent. After triggering pEMT these and other metrics of UJT versus pEMT diverge. A computational model attributes effects of pEMT mainly to diminished junctional tension but attributes those of UJT mainly to augmented cellular propulsion. Through the actions of UJT and pEMT working independently, sequentially, or interactively, those tissues that are subject to development, injury, or disease become endowed with rich mechanisms for cellular migration, plasticity, self-repair, and regeneration. During repair, development, or cancer metastasis, epithelial cells can become migratory through partial or full epithelial to mesenchymal transition (EMT). Here, the authors report that differentiated epithelial collectives may undergo cooperative and collective migration without evidence of partial EMT through an unjamming transition (UJT).
Website Age:
30 years and 10 months (reg. 1994-08-11).

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Keywords {🔍}

cell, pubmed, article, cells, google, scholar, cas, ujt, pemt, epithelial, fig, central, cellular, migration, collective, supplementary, transition, emt, data, packs, biol, mesenchymal, nature, cancer, ads, airway, layer, shape, edge, dynamic, junctions, tension, donors, cellcell, jammed, nat, migratory, size, development, mechanical, epithelialmesenchymal, hbe, ecadherin, pack, dvm, versus, tissue, control, increases, markers,

Topics {✒️}

nature portfolio privacy policy nf-kappab/rela signaling network advertising reprints $${\rm{{tortuosity}}} = \frac{{{\rm{{contour}}} jin-ah park cell shape index medial f-actin fibers source data file post-hoc multiple comparisons l_0 = v_0\tau_{\rm{{ transforming growth factor-beta1 emt-inducing transcription factor emt-inducing transcription factors research design interdisciplinary research open sci tgf-beta-induced epithelial real-time qrt-pcr emt-inducing tf zeb1 nature nature 556 nature 561 nature 429 nature 573 nature 547 nature 527 reporting summary degradable basal transwell-insert peer review dextran-fitc flux assay open real-time quantitative pcr recombinant human tgf-β1 shared similar shape-orientation e-cadherin protein decreased shape index epithelial–mesenchymal transformation based promotes collective motility fold-change relative control rneasy mini kit permissions culture media consisted disassembled cell–cell junctions forming cell–cell junctions allowing cell–cell junctions cell–cell adhesion molecules cell–cell adhesion diminishes research

Questions {❓}

  • Do airway epithelium air-liquid cultures represent the in vivo airway epithelium transcriptome?
  • EMT and MET: necessary or permissive for metastasis?

Schema {🗺️}

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      headline:In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition
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      name:Harvard T.H. Chan School of Public Health, Boston, USA
      name:Harvard T.H. Chan School of Public Health, Boston, USA
      name:Instituto de Neurociencias (CSIC-UMH), Alicante, Spain
      name:Harvard T.H. Chan School of Public Health, Boston, USA
      name:Harvard T.H. Chan School of Public Health, Boston, USA
      name:Instituto de Neurociencias (CSIC-UMH), Alicante, Spain
      name:Department of Physics, Northeastern University, Boston, USA
      name:Harvard T.H. Chan School of Public Health, Boston, USA

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