NATURE . COM {}

Matching Content Categories {📚}

• Science
• Health & Fitness
• Education

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$63,100 per month
Estimations show Nature.com's display ad online revenue falls between $42,042 and $115,616 per month.

Keywords {🔍}

skp, akt, ampk, cells, activation, cancer, phosphorylation, fig, cell, article, knockdown, egf, ubiquitination, supplementary, google, scholar, hypoxia, glucose, ampkα, kinase, survival, cas, mdamb, stresses, stress, tumor, immunoblotting, cat, growth, deprivation, scf, breast, control, assay, signaling, diverse, complex, treatment, resistance, klinked, nature, ligase, expression, restoration, camkkβ, cul, dilution, data, activated, induced,

Topics {✒️}

nature portfolio privacy policy author information authors research institute cancer research advertising pi3k-akt-gsk3beta signaling pathway ampk-skp2-akt axis regulates china medical university methods cell culture middle panel nature 485 nature 408 nature 416 nature data availability original author reprints ampk-skp2-akt axis contributes ampk-skp2 axis regulates α9-nicotinic acetylcholine receptor h2o2-induced k63-linked ubiquitination open platform kinase inhibitor library k63-specific ubiquitin antibody endogenous k63-linked ubquitination chi-mei medical center egf-mediated plcγ activation36 references vivanco cardiac acetyl-coa carboxylase hui-kuan lin egf-mediated biological functions drive skp2-mediated ubiquitination ca2+/calmodulin-dependent kinase induced k63-linked ubiquitination drive k63-linked ubiquitination late-stage breast cancer pi3k/akt/mtor pathway skp2-scf complex consists experimentally-driven mathematical model fisher scientific vita scientific development coupled ampkα1/α2 double knockout egf-mediated akt ubiquitination ampk-skp2-akt axis mda-mb-361 cancer cells 2 µg/ml puromycin selected mda-mb-231 cells starved mda-mb-231 cells pretreated

Questions {❓}

• Can vildagliptin protect against radiation-induced premature ovarian failure?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance
         description:PI3K/Akt signaling is activated in cancers and governs tumor initiation and progression, but how Akt is activated under diverse stresses is poorly understood. Here we identify AMPK as an essential regulator for Akt activation by various stresses. Surprisingly, AMPK is also activated by growth factor EGF through Ca2+/Calmodulin-dependent kinase and is essential for EGF-mediated Akt activation and biological functions. AMPK phosphorylates Skp2 at S256 and promotes the integrity and E3 ligase activity of Skp2 SCF complex leading to K63-linked ubiquitination and activation of Akt and subsequent oncogenic processes. Importantly, AMPK-mediated Skp2 S256 phosphorylation promotes breast cancer progression in mouse tumor models, correlates with Akt and AMPK activation in breast cancer patients, and predicts poor survival outcomes. Finally, targeting AMPK-mediated Skp2 S256 phosphorylation sensitizes cells to anti-EGF receptor targeted therapy. Our study sheds light on how stress and EGF induce Akt activation and new mechanisms for AMPK-mediated oncogenesis and drug resistance. How Akt pathway is activated under stress is poorly understood. Here, the authors demonstrate the crucial role of AMPK for cellular stresses and growth factors- mediated Akt activation through a mechanism involving the E3 ubiquitin ligase Skp2 and Cullin-1.
         datePublished:2018-11-09T00:00:00Z
         dateModified:2018-11-09T00:00:00Z
         pageStart:1
         pageEnd:16
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/s41467-018-07188-9
         keywords:
            Oncogenes
            Phosphorylation
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-07188-9/MediaObjects/41467_2018_7188_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-07188-9/MediaObjects/41467_2018_7188_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-07188-9/MediaObjects/41467_2018_7188_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-07188-9/MediaObjects/41467_2018_7188_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-07188-9/MediaObjects/41467_2018_7188_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-07188-9/MediaObjects/41467_2018_7188_Fig6_HTML.png
         isPartOf:
            name:Nature Communications
            issn:
               2041-1723
            volumeNumber:9
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Fei Han
               affiliation:
                     name:Wake Forest School of Medicine
                     address:
                        name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                        type:PostalAddress
                     type:Organization
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chien-Feng Li
               affiliation:
                     name:Chi-Mei Foundational Medical Center
                     address:
                        name:Department of Pathology, Chi-Mei Foundational Medical Center, Tainan, Taiwan
                        type:PostalAddress
                     type:Organization
                     name:National Health Research Institutes
                     address:
                        name:National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zhen Cai
               affiliation:
                     name:Wake Forest School of Medicine
                     address:
                        name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                        type:PostalAddress
                     type:Organization
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xian Zhang
               url:http://orcid.org/0000-0001-9674-7886
               affiliation:
                     name:Wake Forest School of Medicine
                     address:
                        name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                        type:PostalAddress
                     type:Organization
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Guoxiang Jin
               affiliation:
                     name:Wake Forest School of Medicine
                     address:
                        name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                        type:PostalAddress
                     type:Organization
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wei-Na Zhang
               affiliation:
                     name:Wake Forest School of Medicine
                     address:
                        name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chuan Xu
               affiliation:
                     name:Wake Forest School of Medicine
                     address:
                        name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chi-Yun Wang
               affiliation:
                     name:Wake Forest School of Medicine
                     address:
                        name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                        type:PostalAddress
                     type:Organization
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:John Morrow
               affiliation:
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shuxing Zhang
               affiliation:
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Dazhi Xu
               affiliation:
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
                     name:Sun Yat-Sen University Cancer Center
                     address:
                        name:Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Guihua Wang
               affiliation:
                     name:Wake Forest School of Medicine
                     address:
                        name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Hui-Kuan Lin
               affiliation:
                     name:Wake Forest School of Medicine
                     address:
                        name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                        type:PostalAddress
                     type:Organization
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
                     name:China Medical University
                     address:
                        name:Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
                        type:PostalAddress
                     type:Organization
                     name:Asia University
                     address:
                        name:Department of Biotechnology, Asia University, Taichung, Taiwan
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance
      description:PI3K/Akt signaling is activated in cancers and governs tumor initiation and progression, but how Akt is activated under diverse stresses is poorly understood. Here we identify AMPK as an essential regulator for Akt activation by various stresses. Surprisingly, AMPK is also activated by growth factor EGF through Ca2+/Calmodulin-dependent kinase and is essential for EGF-mediated Akt activation and biological functions. AMPK phosphorylates Skp2 at S256 and promotes the integrity and E3 ligase activity of Skp2 SCF complex leading to K63-linked ubiquitination and activation of Akt and subsequent oncogenic processes. Importantly, AMPK-mediated Skp2 S256 phosphorylation promotes breast cancer progression in mouse tumor models, correlates with Akt and AMPK activation in breast cancer patients, and predicts poor survival outcomes. Finally, targeting AMPK-mediated Skp2 S256 phosphorylation sensitizes cells to anti-EGF receptor targeted therapy. Our study sheds light on how stress and EGF induce Akt activation and new mechanisms for AMPK-mediated oncogenesis and drug resistance. How Akt pathway is activated under stress is poorly understood. Here, the authors demonstrate the crucial role of AMPK for cellular stresses and growth factors- mediated Akt activation through a mechanism involving the E3 ubiquitin ligase Skp2 and Cullin-1.
      datePublished:2018-11-09T00:00:00Z
      dateModified:2018-11-09T00:00:00Z
      pageStart:1
      pageEnd:16
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/s41467-018-07188-9
      keywords:
         Oncogenes
         Phosphorylation
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-07188-9/MediaObjects/41467_2018_7188_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-07188-9/MediaObjects/41467_2018_7188_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-07188-9/MediaObjects/41467_2018_7188_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-07188-9/MediaObjects/41467_2018_7188_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-07188-9/MediaObjects/41467_2018_7188_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-07188-9/MediaObjects/41467_2018_7188_Fig6_HTML.png
      isPartOf:
         name:Nature Communications
         issn:
            2041-1723
         volumeNumber:9
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Fei Han
            affiliation:
                  name:Wake Forest School of Medicine
                  address:
                     name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                     type:PostalAddress
                  type:Organization
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chien-Feng Li
            affiliation:
                  name:Chi-Mei Foundational Medical Center
                  address:
                     name:Department of Pathology, Chi-Mei Foundational Medical Center, Tainan, Taiwan
                     type:PostalAddress
                  type:Organization
                  name:National Health Research Institutes
                  address:
                     name:National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zhen Cai
            affiliation:
                  name:Wake Forest School of Medicine
                  address:
                     name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                     type:PostalAddress
                  type:Organization
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xian Zhang
            url:http://orcid.org/0000-0001-9674-7886
            affiliation:
                  name:Wake Forest School of Medicine
                  address:
                     name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                     type:PostalAddress
                  type:Organization
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Guoxiang Jin
            affiliation:
                  name:Wake Forest School of Medicine
                  address:
                     name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                     type:PostalAddress
                  type:Organization
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wei-Na Zhang
            affiliation:
                  name:Wake Forest School of Medicine
                  address:
                     name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chuan Xu
            affiliation:
                  name:Wake Forest School of Medicine
                  address:
                     name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chi-Yun Wang
            affiliation:
                  name:Wake Forest School of Medicine
                  address:
                     name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                     type:PostalAddress
                  type:Organization
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:John Morrow
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shuxing Zhang
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dazhi Xu
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
                  name:Sun Yat-Sen University Cancer Center
                  address:
                     name:Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Guihua Wang
            affiliation:
                  name:Wake Forest School of Medicine
                  address:
                     name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Hui-Kuan Lin
            affiliation:
                  name:Wake Forest School of Medicine
                  address:
                     name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
                     type:PostalAddress
                  type:Organization
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
                  name:China Medical University
                  address:
                     name:Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
                     type:PostalAddress
                  type:Organization
                  name:Asia University
                  address:
                     name:Department of Biotechnology, Asia University, Taichung, Taiwan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Nature Communications
      issn:
         2041-1723
      volumeNumber:9
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Wake Forest School of Medicine
      address:
         name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:Chi-Mei Foundational Medical Center
      address:
         name:Department of Pathology, Chi-Mei Foundational Medical Center, Tainan, Taiwan
         type:PostalAddress
      name:National Health Research Institutes
      address:
         name:National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan
         type:PostalAddress
      name:Wake Forest School of Medicine
      address:
         name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:Wake Forest School of Medicine
      address:
         name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:Wake Forest School of Medicine
      address:
         name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:Wake Forest School of Medicine
      address:
         name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
         type:PostalAddress
      name:Wake Forest School of Medicine
      address:
         name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
         type:PostalAddress
      name:Wake Forest School of Medicine
      address:
         name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:Sun Yat-Sen University Cancer Center
      address:
         name:Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, China
         type:PostalAddress
      name:Wake Forest School of Medicine
      address:
         name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
         type:PostalAddress
      name:Wake Forest School of Medicine
      address:
         name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:China Medical University
      address:
         name:Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
         type:PostalAddress
      name:Asia University
      address:
         name:Department of Biotechnology, Asia University, Taichung, Taiwan
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Fei Han
      affiliation:
            name:Wake Forest School of Medicine
            address:
               name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
               type:PostalAddress
            type:Organization
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Chien-Feng Li
      affiliation:
            name:Chi-Mei Foundational Medical Center
            address:
               name:Department of Pathology, Chi-Mei Foundational Medical Center, Tainan, Taiwan
               type:PostalAddress
            type:Organization
            name:National Health Research Institutes
            address:
               name:National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan
               type:PostalAddress
            type:Organization
      name:Zhen Cai
      affiliation:
            name:Wake Forest School of Medicine
            address:
               name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
               type:PostalAddress
            type:Organization
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Xian Zhang
      url:http://orcid.org/0000-0001-9674-7886
      affiliation:
            name:Wake Forest School of Medicine
            address:
               name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
               type:PostalAddress
            type:Organization
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Guoxiang Jin
      affiliation:
            name:Wake Forest School of Medicine
            address:
               name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
               type:PostalAddress
            type:Organization
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Wei-Na Zhang
      affiliation:
            name:Wake Forest School of Medicine
            address:
               name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
               type:PostalAddress
            type:Organization
      name:Chuan Xu
      affiliation:
            name:Wake Forest School of Medicine
            address:
               name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
               type:PostalAddress
            type:Organization
      name:Chi-Yun Wang
      affiliation:
            name:Wake Forest School of Medicine
            address:
               name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
               type:PostalAddress
            type:Organization
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:John Morrow
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Shuxing Zhang
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Dazhi Xu
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
            name:Sun Yat-Sen University Cancer Center
            address:
               name:Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Guihua Wang
      affiliation:
            name:Wake Forest School of Medicine
            address:
               name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Hui-Kuan Lin
      affiliation:
            name:Wake Forest School of Medicine
            address:
               name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
               type:PostalAddress
            type:Organization
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
            name:China Medical University
            address:
               name:Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
               type:PostalAddress
            type:Organization
            name:Asia University
            address:
               name:Department of Biotechnology, Asia University, Taichung, Taiwan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
      name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Pathology, Chi-Mei Foundational Medical Center, Tainan, Taiwan
      name:National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan
      name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
      name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
      name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
      name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
      name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
      name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
      name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, China
      name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
      name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
      name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
      name:Department of Biotechnology, Asia University, Taichung, Taiwan

Social Networks {👍}(2)

• https://www.facebook.com/NatureCommunications
• https://twitter.com/NatureComms

External Links {🔗}(151)

• How much does https://orcid.org/0000-0001-9674-7886 pull in monthly?
• What's the financial outcome of https://doi.org/10.1038%2Fnrc839?
• How much profit is http://scholar.google.com/scholar_lookup?&title=The%20phosphatidylinositol%203-Kinase%20AKT%20pathway%20in%20human%20cancer&journal=Nat.%20Rev.%20Cancer&doi=10.1038%2Fnrc839&volume=2&pages=489-501&publication_year=2002&author=Vivanco%2CI&author=Sawyers%2CCL making per month?
• Revenue of https://doi.org/10.1126%2Fscience.296.5573.1655
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2002Sci...296.1655C earn?
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=The%20phosphoinositide%203-kinase%20pathway&journal=Science&doi=10.1126%2Fscience.296.5573.1655&volume=296&pages=1655-1657&publication_year=2002&author=Cantley%2CLC
• How much does http://scholar.google.com/scholar_lookup?&title=The%20phosphoinositide%203-kinase%20pathway&journal=Science&volume=296&pages=1655-1657&publication_year=2001&author=LC.%2CC make?
• What's the financial outcome of https://doi.org/10.1101%2Fgad.13.22.2905?
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Cellular%20survival%3A%20a%20play%20in%20three%20Akts&journal=Genes%20%26%20Development&doi=10.1101%2Fgad.13.22.2905&volume=13&issue=22&pages=2905-2927&publication_year=1999&author=Datta%2CS.%20R.&author=Brunet%2CA.&author=Greenberg%2CM.%20E.
• Learn about the earnings of https://doi.org/10.1016%2Fj.cell.2007.06.009
• Revenue of http://scholar.google.com/scholar_lookup?&title=AKT%2FPKB%20signaling%3A%20navigating%20downstream&journal=Cell&doi=10.1016%2Fj.cell.2007.06.009&volume=129&pages=1261-1274&publication_year=2007&author=Manning%2CBD&author=Cantley%2CLC
• Explore the financials of https://doi.org/10.1016%2Fj.cell.2012.02.065
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=The%20Skp2-SCF%20E3%20ligase%20regulates%20Akt%20ubiquitination%2C%20glycolysis%2C%20herceptin%20sensitivity%2C%20and%20tumorigenesis&journal=Cell&doi=10.1016%2Fj.cell.2012.02.065&volume=149&pages=1098-1111&publication_year=2012&author=Chan%2CCH?
• Find out how much https://doi.org/10.1126%2Fscience.1175065 earns monthly
• What's the monthly money flow for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009Sci...325.1134Y?
• How much does http://scholar.google.com/scholar_lookup?&title=The%20E3%20ligase%20TRAF6%20regulates%20Akt%20ubiquitination%20and%20activation&journal=Science&doi=10.1126%2Fscience.1175065&volume=325&pages=1134-1138&publication_year=2009&author=Yang%2CWL net monthly?
• Get to know what's the income of https://doi.org/10.1038%2Fnrc3064
• How much income does http://scholar.google.com/scholar_lookup?&title=Targeting%20hypoxia%20in%20cancer%20therapy&journal=Nat.%20Rev.%20Cancer&doi=10.1038%2Fnrc3064&volume=11&pages=393-410&publication_year=2011&author=Wilson%2CWR&author=Hay%2CMP have?
• Learn about the earnings of https://doi.org/10.1016%2FS0898-6568%2800%2900128-5
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=Hypoxia%20activates%20Akt%20and%20induces%20phosphorylation%20of%20GSK-3%20in%20PC12%20cells&journal=Cell.%20Signal.&doi=10.1016%2FS0898-6568%2800%2900128-5&volume=13&pages=23-27&publication_year=2001&author=Dana%20Beitner-Johnson%2CRTR&author=Hsieh%2CTykenC&author=Millhorn%2CDavidE
• Monthly income for https://doi.org/10.1074%2Fjbc.M011688200
• Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Hypoxia%20induces%20the%20activation%20of%20the%20phosphatidylinositol%203-kinase%2FAkt%20cell%20survival%20pathway%20in%20PC12%20cells%3A%20protective%20role%20in%20apoptosis&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M011688200&volume=276&pages=22368-22374&publication_year=2001&author=Alvarez-Tejado%2CM
• Revenue of https://link.springer.com/doi/10.1186/1471-2407-12-463
• How much does http://scholar.google.com/scholar_lookup?&title=Activation%20of%20AKT%20by%20hypoxia%3A%20a%20potential%20target%20for%20hypoxic%20tumors%20of%20the%20head%20and%20neck&journal=BMC%20Cancer&doi=10.1186%2F1471-2407-12-463&volume=12&publication_year=2012&author=Stegeman%2CH bring in each month?
• How much does https://doi.org/10.1074%2Fjbc.M115.664169 bring in each month?
• Income figures for http://scholar.google.com/scholar_lookup?&title=Endoplasmic%20reticulum%20%28ER%29%20stress%20induces%20sirtuin%201%20%28SIRT1%29%20expression%20via%20the%20PI3K-Akt-GSK3beta%20signaling%20pathway%20and%20promotes%20hepatocellular%20injury&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M115.664169&volume=290&pages=30366-30374&publication_year=2015&author=Koga%2CT
• Monthly income for https://doi.org/10.1038%2Fnrc.2015.2
• How much does http://scholar.google.com/scholar_lookup?&title=DNA%20damage%20and%20the%20balance%20between%20survival%20and%20death%20in%20cancer%20biology&journal=Nat.%20Rev.%20Cancer&doi=10.1038%2Fnrc.2015.2&volume=16&pages=20-33&publication_year=2016&author=Roos%2CWP&author=Thomas%2CAD&author=Kaina%2CB gross monthly?
• Earnings of https://link.springer.com/doi/10.1186/2046-4053-2-10
• How much money does http://scholar.google.com/scholar_lookup?&title=Survival%20of%20patients%20with%20non-small%20cell%20lung%20cancer%20without%20treatment%3A%20a%20systematic%20review%20and%20meta-analysis&journal=Syst.%20Rev.&doi=10.1186%2F2046-4053-2-10&volume=2&publication_year=2013&author=Wao%2CH&author=Mhaskar%2CR&author=Kumar%2CA&author=Miladinovic%2CB&author=Djulbegovic%2CB generate?
• How much does https://doi.org/10.1177%2F1758834015595048 pull in?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Overcoming%20resistance%20to%20targeted%20therapies%20in%20NSCLC%3A%20current%20approaches%20and%20clinical%20application&journal=Ther.%20Adv.%20Med.%20Oncol.&doi=10.1177%2F1758834015595048&volume=7&pages=263-273&publication_year=2015&author=Maione%2CP?
• Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25232485's earnings
• What's the monthly money flow for http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163608?
• What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=EGFR-TKI%20resistance%20in%20NSCLC%20patients%3A%20mechanisms%20and%20strategies&journal=Am.%20J.%20Cancer%20Res.&volume=4&pages=411-435&publication_year=2014&author=Lin%2CY&author=Wang%2CX&author=Jin%2CH?
• How much does https://doi.org/10.1128%2FMCB.00147-14 bring in each month?
• http://scholar.google.com/scholar_lookup?&title=The%20Pim-1%20protein%20kinase%20is%20an%20important%20regulator%20of%20MET%20receptor%20tyrosine%20kinase%20levels%20and%20signaling&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.00147-14&volume=34&pages=2517-2532&publication_year=2014&author=Cen%2CB income
• https://doi.org/10.1074%2Fjbc.C100271200's financial summary
• What's the profit of http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20Akt%2FPKB%20activation%20by%20tyrosine%20phosphorylation&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.C100271200&volume=276&pages=31858-31862&publication_year=2001&author=Chen%2CR?
• Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11289110's earnings
• Monthly income for http://scholar.google.com/scholar_lookup?&title=Hypoxia%20activates%20a%20platelet-derived%20growth%20factor%20receptor%2Fphosphatidylinositol%203-kinase%2FAkt%20pathway%20that%20results%20in%20glycogen%20synthase%20kinase-3%20inactivation&journal=Cancer%20Res.&volume=61&pages=2429-2433&publication_year=2001&author=Chen%2CEY&author=Mazure%2CNM&author=Cooper%2CJA&author=Giaccia%2CAJ
• Monthly income for https://doi.org/10.1128%2FMCB.05124-11
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Hypoxia%20triggers%20AMPK%20activation%20through%20reactive%20oxygen%20species-mediated%20activation%20of%20calcium%20release-activated%20calcium%20channels&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.05124-11&volume=31&pages=3531-3545&publication_year=2011&author=Mungai%2CPT generate?
• Revenue of https://doi.org/10.1016%2FS0092-8674%2803%2900929-2
• http://scholar.google.com/scholar_lookup?&title=TSC2%20mediates%20cellular%20energy%20response%20to%20control%20cell%20growth%20and%20survival&journal=Cell&doi=10.1016%2FS0092-8674%2803%2900929-2&volume=115&pages=577-590&publication_year=2003&author=Inoki%2CK&author=Zhu%2CT&author=Guan%2CKL's revenue stream
• Check the income stats for https://doi.org/10.1038%2Fnature11066
• How much profit is http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2012Natur.485..661J making per month?
• What are the earnings of http://scholar.google.com/scholar_lookup?&title=AMPK%20regulates%20NADPH%20homeostasis%20to%20promote%20tumour%20cell%20survival%20during%20energy%20stress&journal=Nature&doi=10.1038%2Fnature11066&volume=485&pages=661-665&publication_year=2012&author=Jeon%2CSM&author=Chandel%2CNS&author=Hay%2CN?
• What's the income generated by https://doi.org/10.4161%2Fcl.22651 each month?
• What are the earnings of http://scholar.google.com/scholar_lookup?&title=The%20dark%20face%20of%20AMPK%20as%20an%20essential%20tumor%20promoter&journal=Cell.%20Logist.&doi=10.4161%2Fcl.22651&volume=2&pages=197-202&publication_year=2012&author=Jeon%2CSM&author=Hay%2CN?
• How profitable is https://doi.org/10.1038%2Fonc.2013.2?
• What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Site-specific%20activation%20of%20AKT%20protects%20cells%20from%20death%20induced%20by%20glucose%20deprivation&journal=Oncogene&doi=10.1038%2Fonc.2013.2&volume=33&pages=745-755&publication_year=2014&author=Gao%2CM?
• What's the profit of https://doi.org/10.1074%2Fjbc.275.19.14624?
• What's the income generated by http://scholar.google.com/scholar_lookup?&title=Epidermal%20growth%20factor%20receptor-dependent%20Akt%20activation%20by%20oxidative%20stress%20enhances%20cell%20survival&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.275.19.14624&volume=275&pages=14624-14631&publication_year=2000&author=Wang%2CX&author=McCullough%2CKD&author=Franke%2CTF&author=Holbrook%2CNJ each month?
• Income figures for https://doi.org/10.1073%2Fpnas.0308061100
• What's the monthly money flow for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2004PNAS..101.3329S?
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=The%20tumor%20suppressor%20LKB1%20kinase%20directly%20activates%20AMP-activated%20kinase%20and%20regulates%20apoptosis%20in%20response%20to%20energy%20stress&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0308061100&volume=101&pages=3329-3335&publication_year=2004&author=Shaw%2CRJ
• How much does https://doi.org/10.1371%2Fjournal.pone.0047900 net monthly?
• What's the revenue for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2012PLoSO...747900M?
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=CaMKKbeta%20is%20involved%20in%20AMP-activated%20protein%20kinase%20activation%20by%20baicalin%20in%20LKB1%20deficient%20cell%20lines&journal=PLoS%20One&doi=10.1371%2Fjournal.pone.0047900&volume=7&publication_year=2012&author=Ma%2CY have monthly?
• What's the monthly income of https://doi.org/10.1073%2Fpnas.95.13.7451?
• How much profit is http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1998PNAS...95.7451L making per month?
• How much profit is http://scholar.google.com/scholar_lookup?&title=Human%20CUL1%20forms%20an%20evolutionarily%20conserved%20ubiquitin%20ligase%20complex%20%28SCF%29%20with%20SKP1%20and%20an%20F-box%20protein&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.95.13.7451&volume=95&pages=7451-7456&publication_year=1998&author=Lyapina%2CSA&author=Correll%2CCC&author=Kipreos%2CET&author=Deshaies%2CRJ making per month?
• How much does https://doi.org/10.1074%2Fjbc.M412994200 make?
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=Glucose%20deprivation%20increases%20mRNA%20stability%20of%20vascular%20endothelial%20growth%20factor%20through%20activation%20of%20AMP-activated%20protein%20kinase%20in%20DU145%20prostate%20carcinoma&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M412994200&volume=280&pages=9963-9972&publication_year=2005&author=Yun%2CH&author=Lee%2CM&author=Kim%2CSS&author=Ha%2CJ
• How much revenue does https://link.springer.com/doi/10.1007/s00280-012-2043-3 generate?
• Earnings of http://scholar.google.com/scholar_lookup?&title=Overcoming%20acquired%20resistance%20to%20anticancer%20therapy%3A%20focus%20on%20the%20PI3K%2FAKT%2FmTOR%20pathway&journal=Cancer%20Chemother.%20Pharmacol.&doi=10.1007%2Fs00280-012-2043-3&volume=71&pages=829-842&publication_year=2013&author=Burris%2CHA
• Financial intake of https://doi.org/10.1038%2Fsj.bjc.6602559
• Get to know http://scholar.google.com/scholar_lookup?&title=Reduction%20of%20PTEN%20protein%20and%20loss%20of%20epidermal%20growth%20factor%20receptor%20gene%20mutation%20in%20lung%20cancer%20with%20natural%20resistance%20to%20gefitinib%20%28IRESSA%29&journal=Br.%20J.%20Cancer&doi=10.1038%2Fsj.bjc.6602559&volume=92&pages=1711-1719&publication_year=2005&author=Kokubo%2CY's earnings
• How much profit does https://doi.org/10.1016%2Fj.cell.2013.06.048 make?
• How much does http://scholar.google.com/scholar_lookup?&title=Pharmacological%20inactivation%20of%20Skp2%20SCF%20ubiquitin%20ligase%20restricts%20cancer%20stem%20cell%20traits%20and%20cancer%20progression&journal=Cell&doi=10.1016%2Fj.cell.2013.06.048&volume=154&pages=556-568&publication_year=2013&author=Chan%2CCH net monthly?
• What's the financial intake of https://link.springer.com/doi/10.1007/s10555-007-9055-1?
• How much does http://scholar.google.com/scholar_lookup?&title=Hypoxia%20in%20cancer%3A%20significance%20and%20impact%20on%20clinical%20outcome&journal=Cancer%20Metastas&doi=10.1007%2Fs10555-007-9055-1&volume=26&pages=225-239&publication_year=2007&author=Vaupel%2CP&author=Mayer%2CA earn?
• How much does https://doi.org/10.4103%2F1477-3163.106681 pull in?
• Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Dealing%20with%20hunger%3A%20metabolic%20stress%20responses%20in%20tumors&journal=J.%20Carcinog.&doi=10.4103%2F1477-3163.106681&volume=12&publication_year=2013&author=Reid%2CMA&author=Kong%2CM
• Revenue of https://doi.org/10.1016%2Fj.arr.2012.10.004
• Profit of http://scholar.google.com/scholar_lookup?&title=Oxidative%20stress%20and%20cancer%3A%20an%20overview&journal=Ageing%20Res.%20Rev.&doi=10.1016%2Fj.arr.2012.10.004&volume=12&pages=376-390&publication_year=2013&author=Sosa%2CV
• What's the financial gain of https://doi.org/10.1128%2FMCB.24.11.4664-4676.2004?
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=Rap2B-dependent%20stimulation%20of%20phospholipase%20C-epsilon%20by%20epidermal%20growth%20factor%20receptor%20mediated%20by%20c-Src%20phosphorylation%20of%20RasGRP3&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.24.11.4664-4676.2004&volume=24&pages=4664-4676&publication_year=2004&author=Stope%2CMB is on a monthly basis
• What's the financial outcome of https://doi.org/10.1038%2Fnrc2171?
• See how much http://scholar.google.com/scholar_lookup?&title=Calcium%20and%20cancer%3A%20targeting%20Ca2%2Btransport&journal=Nat.%20Rev.%20Cancer&doi=10.1038%2Fnrc2171&volume=7&pages=519-530&publication_year=2007&author=Monteith%2CGR&author=McAndrew%2CD&author=Faddy%2CHM&author=Roberts-Thomson%2CSJ makes per month
• How much profit does https://link.springer.com/doi/10.1007/978-94-007-5561-1_5 make?
• What's http://scholar.google.com/scholar_lookup?&title=Intracellular%20calcium%20homeostasis%20and%20signaling&journal=Metal.%20Ions%20Life%20Sci.&doi=10.1007%2F978-94-007-5561-1_5&volume=12&pages=119-168&publication_year=2013&author=Brini%2CM&author=Cali%2CT&author=Ottolini%2CD&author=Carafoli%2CE's gross income?
• How much revenue does https://doi.org/10.1016%2Fj.bbamem.2014.08.016 produce monthly?
• Monthly income for http://scholar.google.com/scholar_lookup?&title=Altered%20calcium%20signaling%20in%20cancer%20cells&journal=Biochim.%20Biophys.%20Acta&doi=10.1016%2Fj.bbamem.2014.08.016&volume=1848&pages=2502-2511&publication_year=2015&author=Stewart%2CTA&author=Yapa%2CKT&author=Monteith%2CGR
• Monthly income for https://doi.org/10.1016%2Fj.molmed.2012.12.004
• http://scholar.google.com/scholar_lookup?&title=CaMKK2%3A%20a%20novel%20target%20for%20shaping%20the%20androgen-regulated%20tumor%20ecosystem&journal=Trends%20Mol.%20Med.&doi=10.1016%2Fj.molmed.2012.12.004&volume=19&pages=83-88&publication_year=2013&author=Racioppi%2CL's revenue stream
• What's the revenue for https://doi.org/10.1126%2Fscisignal.2004088?
• How much does http://scholar.google.com/scholar_lookup?&title=Integrative%20analysis%20of%20complex%20cancer%20genomics%20and%20clinical%20profiles%20using%20the%20cBioPortal&journal=Sci.%20Signal.&doi=10.1126%2Fscisignal.2004088&volume=6&publication_year=2013&author=Gao%2CJAB make?
• How much cash flow does https://doi.org/10.1074%2Fjbc.M117.778464 have monthly?
• http://scholar.google.com/scholar_lookup?&title=Akt%20activation%20by%20Ca%282%2B%29%2Fcalmodulin-dependent%20protein%20kinase%20kinase%202%20%28CaMKK2%29%20in%20ovarian%20cancer%20cells&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M117.778464&volume=292&pages=14188-14204&publication_year=2017&author=Gocher%2CAM's revenue stream
• Learn about the earnings of https://doi.org/10.1016%2Fj.molcel.2008.03.003
• How much income is http://scholar.google.com/scholar_lookup?&title=AMPK%20phosphorylation%20of%20raptor%20mediates%20a%20metabolic%20checkpoint&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2008.03.003&volume=30&pages=214-226&publication_year=2008&author=Gwinn%2CDM earning monthly?
• Income figures for https://doi.org/10.1038%2Fncb2152
• How much revenue does http://scholar.google.com/scholar_lookup?&title=AMPK%20and%20mTOR%20regulate%20autophagy%20through%20direct%20phosphorylation%20of%20Ulk1&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb2152&volume=13&pages=132-141&publication_year=2011&author=Kim%2CJ&author=Kundu%2CM&author=Viollet%2CB&author=Guan%2CKL produce monthly?
• How much does https://doi.org/10.1046%2Fj.1432-1327.1999.00371.x pull in monthly?
• What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Phosphorylation%20control%20of%20cardiac%20acetyl-CoA%20carboxylase%20by%20cAMP-dependent%20protein%20kinase%20and%205%E2%80%99-AMP%20activated%20protein%20kinase&journal=Eur.%20J.%20Biochem.&doi=10.1046%2Fj.1432-1327.1999.00371.x&volume=262&pages=184-190&publication_year=1999&author=Dyck%2CJR?
• What's the income generated by https://doi.org/10.1038%2F35042620 each month?
• http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2000Natur.408..381S income
• Earnings of http://scholar.google.com/scholar_lookup?&title=Insights%20into%20SCF%20ubiquitin%20ligases%20from%20the%20structure%20of%20the%20Skp1-Skp2%20complex&journal=Nature&doi=10.1038%2F35042620&volume=408&pages=381-386&publication_year=2000&author=Schulman%2CBA
• What's the profit of https://doi.org/10.1038%2F416703a?
• Revenue of http://scholar.google.com/scholar_lookup?&title=Structure%20of%20the%20Cul1%E2%80%93Rbx1%E2%80%93Skp1%E2%80%93F%20boxSkp2%20SCF%20ubiquitin%20ligase%20complex&journal=Nature&doi=10.1038%2F416703a&volume=416&pages=703-709&publication_year=2002&author=BAS%2CNingZheng
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24709008 pull in monthly?
• Profit of http://scholar.google.com/scholar_lookup?&title=Role%20of%20endothelial%20progenitor%20cells%20in%20cancer%20progression&journal=Biochim.%20Biophys.%20Acta&volume=1846&pages=26-39&publication_year=2014&author=Moschetta%2CM
• What is the earnings of https://doi.org/10.1038%2Fsrep30347?
• What's the income generated by http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2016NatSR...630347S each month?
• What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=M2%20tumour-associated%20macrophages%20contribute%20to%20tumour%20progression%20via%20legumain%20remodelling%20the%20extracellular%20matrix%20in%20diffuse%20large%20B%20cell%20lymphoma&journal=Sci.%20Rep.&doi=10.1038%2Fsrep30347&volume=6&publication_year=2016&author=Shen%2CL?
• What's the revenue for https://doi.org/10.1159%2F000088478?
• Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=VEGF%20as%20a%20key%20mediator%20of%20angiogenesis%20in%20cancer&journal=Oncology&doi=10.1159%2F000088478&volume=69&issue=Suppl%203&pages=4-10&publication_year=2005&author=Carmeliet%2CP
• Profit of https://citation-needed.springer.com/v2/references/10.1038/s41467-018-07188-9?format=refman&flavour=references
• What's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Fei%20Han?
• How much income does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Fei%20Han%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have?
• What are the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chien-Feng%20Li?
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chien-Feng%20Li%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's financial summary
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Zhen%20Cai bring in each month?
• Financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Zhen%20Cai%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Xian%20Zhang pull in?
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Xian%20Zhang%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's revenue stream
• Check the income stats for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Guoxiang%20Jin
• Explore the financials of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Guoxiang%20Jin%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Wei-Na%20Zhang bring in each month?
• Learn how profitable https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Wei-Na%20Zhang%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en is on a monthly basis
• How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chuan%20Xu make?
• Learn how profitable https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chuan%20Xu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en is on a monthly basis
• What is the monthly revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chi-Yun%20Wang?
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chi-Yun%20Wang%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=John%20Morrow bring in?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22John%20Morrow%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in monthly?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Shuxing%20Zhang earn?
• Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Shuxing%20Zhang%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• What's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dazhi%20Xu?
• What's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Dazhi%20Xu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Learn about the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Guihua%20Wang
• What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Guihua%20Wang%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What is the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hui-Kuan%20Lin?
• Learn about the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hui-Kuan%20Lin%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-018-07188-9/MediaObjects/41467_2018_7188_MOESM1_ESM.pdf pull in?
• Discover the revenue of https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-018-07188-9/MediaObjects/41467_2018_7188_MOESM2_ESM.pdf
• What's the profit of http://creativecommons.org/licenses/by/4.0/?
• Profit of https://s100.copyright.com/AppDispatchServlet?title=The%20critical%20role%20of%20AMPK%20in%20driving%20Akt%20activation%20under%20stress%2C%20tumorigenesis%20and%20drug%20resistance&author=Fei%20Han%20et%20al&contentID=10.1038%2Fs41467-018-07188-9©right=The%20Author%28s%29&publication=2041-1723&publicationDate=2018-11-09&publisherName=SpringerNature&orderBeanReset=true&oa=CC%20BY
• How much cash flow does https://crossmark.crossref.org/dialog/?doi=10.1038/s41467-018-07188-9 have monthly?
• How much does https://citation-needed.springer.com/v2/references/10.1038/s41467-018-07188-9?format=refman&flavour=citation earn?
• What are the total earnings of https://doi.org/10.1186/s40360-025-00903-5?
• What's the total monthly financial gain of https://doi.org/10.1186/s12906-024-04516-z?
• Learn how profitable https://doi.org/10.1186/s12885-024-12715-7 is on a monthly basis
• How much money does https://doi.org/10.1186/s10020-024-00842-7 make?
• https://doi.org/10.1038/s44318-024-00271-6's revenue stream
• What's the income generated by https://www.protocols.io/ each month?
• https://www.natureindex.com/'s total income per month
• Discover the revenue of http://www.naturechina.com
• How much does https://www.natureasia.com/ja-jp generate monthly?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref