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We are analyzing https://www.nature.com/articles/s41467-018-03915-4.

Title:
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors | Nature Communications
Description:
Vaccines to induce effective and sustained antitumor immunity have great potential for postoperative cancer therapy. However, a robust cancer vaccine simultaneously eliciting tumor-specific immunity and abolishing immune resistance continues to be a challenge. Here we present a personalized cancer vaccine (PVAX) for postsurgical immunotherapy. PVAX is developed by encapsulating JQ1 (a BRD4 inhibitor) and indocyanine green (ICG) co-loaded tumor cells with a hydrogel matrix. Activation of PVAX by 808 nm NIR laser irradiation significantly inhibits the tumor relapse by promoting the maturation of dendritic cells and eliciting tumor infiltration of cytotoxic T lymphocytes. A mechanical study reveals that NIR light-triggered antigen release and JQ1-mediated PD-L1 checkpoint blockade cumulatively contribute to the satisfied therapeutic effect. Furthermore, PVAX prepared from the autologous tumor cells induces patient-specific memory immune response to prevent tumor recurrence and metastasis. The PVAX model might provide novel insights for postoperative immunotherapy. Cancer vaccines represent a promising personalized therapeutic approach to treating cancer. Here, the authors report the efficacy in a metastatic model of a cancer vaccine-mediated postoperative immunotherapy, based on the coencapsulation of the JQ1 and a photosensitizer ICG together with inactivated tumor cells into a hydrogel matrix.
Website Age:
30 years and 10 months (reg. 1994-08-11).

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  • Science
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Custom-built

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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$63,100 per month
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Keywords {🔍}

tumor, cells, cancer, fig, pubmed, article, immune, immunotherapy, tumors, fkiqt, google, scholar, pvax, laser, cas, examined, vaccines, cell, mice, vaccine, days, response, fkiqtl, antitumor, metastasis, supplementary, distant, data, icg, hydrogel, nature, irradiation, treatment, clone, catalog, vivo, release, balbc, vaccination, maturation, post, ebioscience, recurrent, antigens, intratumoral, groups, min, central, lymphocytes, represent,

Topics {✒️}

nature portfolio privacy policy noncovalent crosslinking nature advertising frontier scientific social media tumor-specific anti-metastasis property long-lasting anticancer responses reprints nature 520 nature 515 nature tnf-α+/ifn-γ+ cd8+ nir laser-triggered activation patient-specific immune response pd-l1/pd-1 blockade pd-1/pd-l1 blockade iq-4t1-loaded fk hydrogels pd-1/pd-l1 checkpoint pd-l1/pd-1 checkpoint suppressing pd-l1 expression acid-triggered precise imaging immune-related adverse events enzyme-linked immunosorbent assays nir light-controlled manner cancer-cell-biomimetic nanoparticles tumor specific ifn-γ anti-cd44-percp-cy5 laser-triggered drug release laser-triggered fk release systemic anti-tumor immunity pvax-induced immune response high-performance liquid chromatography anti-pd-l1 antibody release patient-specific antigens node-negative breast cancer laser-promoted dc maturation anti-cd3-percp-cy5 peptide-network weaved nanoplatform antigen-capturing nanoparticles improve sustained immune-memory effect laser-triggered jq1 release elicit pd-l1 expression anti-ifn-γ-fitc suggesting tumor-specific delivery anti-tnf-α-alexa 647 evaluate laser-induced release 4t1 tumor-bearing mouse tumor-penetrating peptide enhances allowing iq-4t1 encapsulation

Schema {🗺️}

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      name:State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
      name:Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
      name:State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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