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Title[redir]:
Co-administration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs - PMC
Description:
Poor penetration of anti-cancer drugs into tumors can be an important factor limiting their efficacy. Studying mouse tumor models, we show that a previously characterized tumor-penetrating peptide, iRGD (CRGDK/RGPD/EC), increased vascular and tissue ...
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Keywords {🔍}
doi, irgd, fig, tumor, tumors, pubmed, google, scholar, cancer, drug, dox, peptide, pmc, drugs, combination, human, mice, treatment, free, article, trastuzumab, penetration, cendr, mgkg, therapy, dose, efficacy, effect, delivery, enhanced, abx, orthotopic, group, pbs, tissue, injected, nlm, ruoslahti, permeability, conjugated, antibody, activity, accumulation, prostate, results, intravenously, bearing, fold, cell, breast,
Topics {✒️}
table nihms200073-supplement-table overexpress her2/neu/erbb2 anti-human igg antibody gfp-pc-3 cell line tumor-bearing mice pmc beta search conditional c-end rule daily injections human prostate tumor cendr-triggered vascular permeability tumor-penetrating peptide enhances supplementary materials included tumor-homing cendr peptides c-terminal cendr motif caused tumor-specific accumulation anti-nrp-1 antibody inhibited irgd-mediated delivery remain human albumin antibody anti-cancer drugs penetrate fam-crgdc-positive areas bt474 tumor mice main dose-limiting toxicity human leukocyte antigens license information pmcid separate entities triggers human tumor vessels c-terminal exposure c-terminal elements monitoring vascular permeability 3 mg paclitaxel/kg/injection important factor limiting body weight shift subsequent injections anti-taxol antibody extravascular tumor tissue neuropilin-1-dependent manner albumin-embedded paclitaxel publisher site pdf exclude circulatory effects tumor-penetrating peptide united states government final edited form generally high expression iron-oxide nanoworms phosphate-buffered saline 2-week observation period 3 weeks tumor targeting methodology permeabilize tumor vasculature tumor imaging agents
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