Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Questions
  10. Schema
  11. Social Networks
  12. External Links
  13. Analytics And Tracking
  14. Libraries
  15. Hosting Providers
  16. CDN Services

We are analyzing https://www.nature.com/articles/s41420-020-0265-4.

Title:
Regulation of TFEB activity and its potential as a therapeutic target against kidney diseases | Cell Death Discovery
Description:
The transcription factor EB (TFEB) regulates the expression of target genes bearing the Coordinated Lysosomal Expression and Regulation (CLEAR) motif, thereby modulating autophagy and lysosomal biogenesis. Furthermore, TFEB can bind to the promoter of autophagy-associated genes and induce the formation of autophagosomes, autophagosome–lysosome fusion, and lysosomal cargo degradation. An increasing number of studies have shown that TFEB stimulates the intracellular clearance of pathogenic factors by enhancing autophagy and lysosomal function in multiple kidney diseases, such as cystinosis, acute kidney injury, and diabetic nephropathy. Taken together, this highlights the importance of developing novel therapeutic strategies against kidney diseases based on TFEB regulation. In this review, we present an overview of the current data on TFEB and its implication in kidney disease.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,194,993 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$531,700 per month
Our analysis indicates Nature.com generates between $354,480 and $974,820 monthly online from display ads.

Keywords {🔍}

pubmed, tfeb, article, google, scholar, cas, autophagy, kidney, central, lysosomal, cell, injury, biogenesis, cells, mitochondrial, function, cystinosis, disease, renal, diabetic, transcription, activation, expression, acute, cellular, tubular, aki, therapeutic, regulates, diseases, patients, nature, mitophagy, activity, factor, genes, clearance, diabetes, biol, mol, target, nephropathy, mtorc, involved, content, regulation, promotes, intracellular, lysosomes, protein,

Topics {✒️}

nature portfolio basic helix–loop–helix-leucine-zipper nature 436 nature bhlh basic helix–loop–helix basic helix-loop-helix protein privacy policy advertising social media yanse chen & huafeng liu reprints advanced glycation end-products helix-loop-helix protein pgc-1α-dependent tubular protection short interfering rna-mediated pgc-1a rescues huntington hyperglycemia-induced podocyte injury ubiquitous ser/thr kinase angiotensin-receptor antagonist irbesartan urinary inflammatory cytokines/chemokines research status chaperone-mediated autophagy leads gln glutamine-rich region proton-cystine symporter responsible disrupted multi-factor interactions starvation-induced autoregulatory loop atypical ser/thr kinase pro proline-rich segment mit/tfe proteins include peroxisome proliferator-activated receptor mit/tfe transcription factors cisplatin-treated rptc cells important ser/thr kinase alpha-1-anti-trypsin deficiency renal ischemia/reperfusion injury ser serine-rich region llc-pk1 cells play stz-induced diabetic mice125 research original author disordered endo-lysosomal compartments sepsis-induced kidney injury folic acid-induced aki permissions transcription factor eb mtor-induced autophagic dysfunction mit/tfe transcriptional factors promote autophagy-lysosomal fitness renal ischaemia–reperfusion injury pgc-1α promotes recovery

Questions {❓}

  • Inhibition and restimulation by insulin of cellular autophagy in distal tubular cells of the kidney in early diabetic rats?
  • Mitochondrial quality control in AMD: does mitophagy play a pivotal role?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Regulation of TFEB activity and its potential as a therapeutic target against kidney diseases
         description:The transcription factor EB (TFEB) regulates the expression of target genes bearing the Coordinated Lysosomal Expression and Regulation (CLEAR) motif, thereby modulating autophagy and lysosomal biogenesis. Furthermore, TFEB can bind to the promoter of autophagy-associated genes and induce the formation of autophagosomes, autophagosome–lysosome fusion, and lysosomal cargo degradation. An increasing number of studies have shown that TFEB stimulates the intracellular clearance of pathogenic factors by enhancing autophagy and lysosomal function in multiple kidney diseases, such as cystinosis, acute kidney injury, and diabetic nephropathy. Taken together, this highlights the importance of developing novel therapeutic strategies against kidney diseases based on TFEB regulation. In this review, we present an overview of the current data on TFEB and its implication in kidney disease.
         datePublished:2020-05-01T00:00:00Z
         dateModified:2020-05-01T00:00:00Z
         pageStart:1
         pageEnd:10
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/s41420-020-0265-4
         keywords:
            Acute kidney injury
            Nephrons
            Life Sciences
            general
            Biochemistry
            Cell Biology
            Stem Cells
            Apoptosis
            Cell Cycle Analysis
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41420-020-0265-4/MediaObjects/41420_2020_265_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41420-020-0265-4/MediaObjects/41420_2020_265_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41420-020-0265-4/MediaObjects/41420_2020_265_Fig3_HTML.png
         isPartOf:
            name:Cell Death Discovery
            issn:
               2058-7716
            volumeNumber:6
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Weihuang Zhang
               affiliation:
                     name:Affiliated Hospital of Guangdong Medical University
                     address:
                        name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaoyu Li
               affiliation:
                     name:Affiliated Hospital of Guangdong Medical University
                     address:
                        name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Shujun Wang
               affiliation:
                     name:Affiliated Hospital of Guangdong Medical University
                     address:
                        name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yanse Chen
               affiliation:
                     name:Affiliated Hospital of Guangdong Medical University
                     address:
                        name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Huafeng Liu
               affiliation:
                     name:Affiliated Hospital of Guangdong Medical University
                     address:
                        name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Regulation of TFEB activity and its potential as a therapeutic target against kidney diseases
      description:The transcription factor EB (TFEB) regulates the expression of target genes bearing the Coordinated Lysosomal Expression and Regulation (CLEAR) motif, thereby modulating autophagy and lysosomal biogenesis. Furthermore, TFEB can bind to the promoter of autophagy-associated genes and induce the formation of autophagosomes, autophagosome–lysosome fusion, and lysosomal cargo degradation. An increasing number of studies have shown that TFEB stimulates the intracellular clearance of pathogenic factors by enhancing autophagy and lysosomal function in multiple kidney diseases, such as cystinosis, acute kidney injury, and diabetic nephropathy. Taken together, this highlights the importance of developing novel therapeutic strategies against kidney diseases based on TFEB regulation. In this review, we present an overview of the current data on TFEB and its implication in kidney disease.
      datePublished:2020-05-01T00:00:00Z
      dateModified:2020-05-01T00:00:00Z
      pageStart:1
      pageEnd:10
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/s41420-020-0265-4
      keywords:
         Acute kidney injury
         Nephrons
         Life Sciences
         general
         Biochemistry
         Cell Biology
         Stem Cells
         Apoptosis
         Cell Cycle Analysis
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41420-020-0265-4/MediaObjects/41420_2020_265_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41420-020-0265-4/MediaObjects/41420_2020_265_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41420-020-0265-4/MediaObjects/41420_2020_265_Fig3_HTML.png
      isPartOf:
         name:Cell Death Discovery
         issn:
            2058-7716
         volumeNumber:6
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Weihuang Zhang
            affiliation:
                  name:Affiliated Hospital of Guangdong Medical University
                  address:
                     name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaoyu Li
            affiliation:
                  name:Affiliated Hospital of Guangdong Medical University
                  address:
                     name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Shujun Wang
            affiliation:
                  name:Affiliated Hospital of Guangdong Medical University
                  address:
                     name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yanse Chen
            affiliation:
                  name:Affiliated Hospital of Guangdong Medical University
                  address:
                     name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Huafeng Liu
            affiliation:
                  name:Affiliated Hospital of Guangdong Medical University
                  address:
                     name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Cell Death Discovery
      issn:
         2058-7716
      volumeNumber:6
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Affiliated Hospital of Guangdong Medical University
      address:
         name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
         type:PostalAddress
      name:Affiliated Hospital of Guangdong Medical University
      address:
         name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
         type:PostalAddress
      name:Affiliated Hospital of Guangdong Medical University
      address:
         name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
         type:PostalAddress
      name:Affiliated Hospital of Guangdong Medical University
      address:
         name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
         type:PostalAddress
      name:Affiliated Hospital of Guangdong Medical University
      address:
         name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Weihuang Zhang
      affiliation:
            name:Affiliated Hospital of Guangdong Medical University
            address:
               name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
               type:PostalAddress
            type:Organization
      name:Xiaoyu Li
      affiliation:
            name:Affiliated Hospital of Guangdong Medical University
            address:
               name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Shujun Wang
      affiliation:
            name:Affiliated Hospital of Guangdong Medical University
            address:
               name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
               type:PostalAddress
            type:Organization
      name:Yanse Chen
      affiliation:
            name:Affiliated Hospital of Guangdong Medical University
            address:
               name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
               type:PostalAddress
            type:Organization
      name:Huafeng Liu
      affiliation:
            name:Affiliated Hospital of Guangdong Medical University
            address:
               name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
      name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
      name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
      name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
      name:Institute of Nephrology, and Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China

Social Networks {👍}(1)

External Links {🔗}(431)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

4.81s.