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We are analyzing https://www.nature.com/articles/s41418-018-0212-6.

Title:
Pyroptosis versus necroptosis: similarities, differences, and crosstalk | Cell Death & Differentiation
Description:
Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell death. Although these cell death programmes can protect the host against microbial pathogens, their dysregulation has been implicated in a variety of autoimmune and auto-inflammatory conditions. The disease-promoting potential of necroptosis and pyroptosis is likely a consequence of their ability to induce a lytic cell death. This cell suicide mechanism, distinct from apoptosis, allows the release of immunogenic cellular content, including damage-associated molecular patterns (DAMPs), and inflammatory cytokines such as interleukin-1β (IL-1β), to trigger inflammation. In this Review, we discuss recent discoveries that have advanced our understanding on the primary functions of pyroptosis and necroptosis, including evidence for the specific cytokines and DAMPs responsible for driving inflammation. We compare the similar and unique aspects of pyroptotic- and necroptotic-induced membrane damage, and explore how these may functionally impact distinct intracellular organelles and signalling pathways. We also examine studies highlighting the crosstalk that can occur between necroptosis and pyroptosis signalling, and evidence supporting the physiological significance of this convergence. Ultimately, a better understanding of the similarities, unique aspects and crosstalk of pyroptosis and necroptosis will inform as to how these cell death pathways might be manipulated for therapeutic benefit.
Website Age:
30 years and 10 months (reg. 1994-08-11).

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Keywords {🔍}

pubmed, google, scholar, cell, cas, death, necroptosis, central, caspase, mlkl, pyroptosis, nlrp, inflammasome, inflammatory, release, membrane, activation, necroptotic, gsdmd, ripk, nature, ilβ, damps, signalling, inflammation, cells, hmgb, apoptosis, pyroptotic, responses, activity, immunol, disease, plasma, immunity, activated, triggers, killing, trigger, released, protein, induce, damage, reported, domain, mice, immune, apoptotic, ilα, nat,

Topics {✒️}

permissions reprints nature portfolio tlr-myd88-induced ciap1-traf2 degradation privacy policy advertising pro-interleukin-1beta protein complexes hmgb1-rage-induced transcriptional responses zbp1/dai-induced ripk3 dimerization tlr-caspase-8-nlrp3 signalling axis caspase-1-mediated interleukin-1beta activation caspase-8-driven il-1beta activation author information authors nlrp3-il-1β signalling axis melbourne research scholarship full access ripk3-mlkl-nlrp3-caspase-1 axis ripk1-ripk3-mlkl signalling complex open questions interleukin-1beta maturation triggers lps-induced il-1β activation acetaminophen-induced liver injury suppress lps-induced necroptosis exerts anti-inflammatory effects inflammasome-mediated pyroptosis promotes recent research inhibitory c-terminal fragment author correspondence rip3-dependent cell death ischaemia-reperfusion injuries involving anti-cancer immune responses extensive research medical research pressure-disrupted necrotic cells renal ischemia/reperfusion injury renal ischemia-reperfusion injury inflammatory anti-microbial response n-terminal 4-helical bundle cytosolic double-stranded dna rip3-mediated macrophage necrosis kidney-ischaemia reperfusion injury heart-beating liver transplantation alter lps-induced lethality anti-il-1 biologics proving dai dna-dependent activator pyroptotic-generated inflammatory response hiv/siv infection lakmini neonate ripk1-deficient mice tnf-induced shock model mlkl-induced membrane perforations activated n-terminal region

Questions {❓}

  • Are there DAMPs that are released that are unique to pyroptosis and necroptosis?
  • Does MLKL-induced NLRP3 inflammasome activity contribute to necroptotic-induced inflammatory disease?
  • How critical are GSDMD membrane pores for IL-1β release and inflammatory responses in different diseases?
  • Necroptotic to pyroptotic crosstalk: is the NLRP3 inflammasome a driver of necroptotic-induced inflammation?
  • Pyroptosis and necroptosis: death with a difference?
  • Therefore, the question arises as to whether necroptosis-induced inflammation might also be driven by the release of inflammasome-activated cytokines?
  • What are the key necroptotic and pyroptotic DAMPs that contribute to inflammatory responses?
  • What are the primary functions of GSDMD-mediated pyroptosis?
  • What are the primary functions of MLKL-mediated necroptosis?

Schema {🗺️}

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