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Title:
Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review | Acta Pharmacologica Sinica
Description:
Colchicine is an ancient herbal drug derived from Colchicum autumnale. It was first used to treat familial Mediterranean fever and gout. Based on its unique efficacy as an anti-inflammatory agent, colchicine has been used in the therapy of cardiovascular diseases including coronary artery disease, atherosclerosis, recurrent pericarditis, vascular restenosis, heart failure, and myocardial infarction. More recently, colchicine has also shown therapeutic efficacy in alleviating cardiovascular complications of COVID-19. COLCOT and LoDoCo2 are two milestone clinical trials that confirm the curative effect of long-term administration of colchicine in reducing the incidence of cardiovascular events in patients with coronary artery disease. There is growing interest in studying the anti-inflammatory mechanisms of colchicine. The anti-inflammatory action of colchicine is mediated mainly through inhibiting the assembly of microtubules. At the cellular level, colchicine inhibits the following: (1) endothelial cell dysfunction and inflammation; (2) smooth muscle cell proliferation and migration; (3) macrophage chemotaxis, migration, and adhesion; (4) platelet activation. At the molecular level, colchicine reduces proinflammatory cytokine release and inhibits NF-κB signaling and NLRP3 inflammasome activation. In this review, we summarize the current clinical trials with proven curative effect of colchicine in treating cardiovascular diseases. We also systematically discuss the mechanisms of colchicine action in cardiovascular therapeutics. Altogether, colchicine, a bioactive constituent from an ancient medicinal herb, exerts unique anti-inflammatory effects and prominent cardiovascular actions, and will charter a new page in cardiovascular medicine.
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nature portfolio permissions reprints privacy policy jama netw open advertising nature suo-wen xu reducing tuba/alpha-tubulin acetylation social media research teams project open biochem innovative research team alleviating cardiovascular complications oxidized low-density lipoprotein author information authors oxidised low-density lipoproteins colchicine toxicity—clinical features crystal-induced neutrophil activation microtubule-mediated nf-kappab activation microtubule-driven spatial arrangement inhibits nf-κb signaling acute myocardial infarction tnf-alpha signaling pathway author correspondence glycoprotein vi stimulation chengxue helena qin cardiovascular complications modulating srf-myocd activation nf-kappab nuclear translocation translational research signal transduction pathway bare-metal stent restenosis microtubule-disassembling drug coronary artery disease nf-kappab signaling pathway early leukocyte development hefei municipal development research permissions anti-inflammatory mechanisms anti-inflammatory agent myocardial infarction personal data access colchicine-pci randomized trial long-term colchicine treatment anti-inflammatory treatment treating cardiovascular diseases coron artery dis nidorf sm
Questions {❓}
- Increased asymmetric dimethylarginine levels in young men with familial Mediterranean fever (FMF): is it early evidence of interaction between inflammation and endothelial dysfunction in FMF?
- Is P-glycoprotein (ABCB1) a phase 0 or a phase 3 colchicine transporter depending on colchicine exposure conditions?
- Mean platelet volume and beta-thromboglobulin levels in familial Mediterranean fever: effect of colchicine use?
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