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aur, pubmed, iron, hepcidin, mice, expression, fig, cells, google, scholar, ferroptosis, mrna, cas, hepatic, hfe, cell, huh, levels, male, central, found, treatment, effect, measured, treated, female, hamp, mgkg, significantly, data, highdose, txnrd, metabolism, nature, serum, activity, content, inhibitor, liver, article, yang, wang, signaling, pathway, auranofin, drug, thioredoxin, increased, supplementary, body,

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nature portfolio privacy policy national key research nature advertising research diets research grants 5 mg/kg body weight/day nf-κb/il-6/stat3 signaling pathway social media development program apoptosis inhibitor z-vad-fmk hepcidin-deficiency related disorders ubiquitin-proteasome system-mediated ferroptosis reprints fda-approved drug library high-dose aur‒induced decrease fda-approved anti-rheumatoid arthritis nf-κb/il-6/stat3 axis treating iron-related diseases 5 mg/kg body weight 25 mg/kg body weight 1 mg/kg body weight 10 mg/kg body weight mapk/erk signaling pathway full size image kaplan–meier survival curves specific pathogen-free facility gold-induced aplastic anemia high-dose aur showed nf-κb inhibitor bay11–7082 xin huang & fudi wang high-dose aur increased long-term aur treatment tumor necrosis factor-alpha bmp6/bmp receptor complex recently identified iron-dependent tfr2/hfe complex triggers induce il-6/hepcidin signaling prevent hydroperoxide-induced ferroptosis myd88-dependent il-6 production gpr30-bmp6-dependent signaling transferrin-induced hepcidin expression nf-κb/il-6 pathway downstream pro-inflammatory cytokines perls’ prussian blue hepatic tnf-α expression high doses—inducing ferroptosis anti-ra drug auranofin bmp/smad/hepcidin axis

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               name:Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou, China
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            name:Xinxiang Medical University
            address:
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               name:Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou, China
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            address:
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            address:
               name:Department of Nutrition and Health, Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China
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               name:Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou, China
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      name:Xin Huang
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      affiliation:
            name:Zhejiang University School of Medicine
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            name:Zhejiang University School of Medicine
            address:
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      affiliation:
            name:Zhejiang University School of Medicine
            address:
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      affiliation:
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            address:
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               type:PostalAddress
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      name:Junxia Min
      url:http://orcid.org/0000-0001-8099-6327
      affiliation:
            name:Zhejiang University School of Medicine
            address:
               name:The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
               type:PostalAddress
            type:Organization
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      name:Fudi Wang
      url:http://orcid.org/0000-0001-8730-0003
      affiliation:
            name:Zhengzhou University
            address:
               name:Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou, China
               type:PostalAddress
            type:Organization
            name:Zhejiang University School of Medicine
            address:
               name:The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:China Agricultural University
            address:
               name:Department of Nutrition and Health, Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou, China
      name:The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
      name:Department of Nutrition and Health, Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China
      name:School of Nursing, Xinxiang Medical University, Xinxiang, China
      name:Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou, China
      name:The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
      name:Department of Nutrition and Health, Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China
      name:The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
      name:The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
      name:Department of Nutrition and Health, Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China
      name:The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
      name:Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou, China
      name:Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou, China
      name:The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
      name:The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
      name:The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
      name:The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
      name:The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
      name:Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou, China
      name:The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
      name:Department of Nutrition and Health, Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China

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