
DEGRUYTERBRILL . COM {
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Title:
Sensitivity of CA 15-3, CEA and serum HER2 in the early detection of recurrence of breast cancer
Description:
Background: The aim of this project was to investigate the sensitivity of CA 15-3, CEA and HER2 in the early diagnosis of metastatic breast cancer. Methods: Serial serum values of CA 15-3, CEA and HER2 were determined in 107 patients with recurrence after breast cancer. Fifteen of the patients had primary disseminated disease, nine patients only developed local recurrence during the follow-up period and the remaining 83 developed distant metastases. Results: In the group of patients with distant metastatic disease (n=83), elevated serum levels of CA 15-3 (>32.4 U/mL), CEA (>2.5 µg/L for non-smokers and >10 µg/L for smokers) and HER2 (>15 µg/L) were found in 49.4%, 38.6% and 32.5%, respectively, at the time of diagnosis of recurrence. CA 15-3 was significantly better than HER2 (p=0.027). The most sensitive combination was obtained using CA 15-3/CEA (60.2%) or CA 15-3/HER2 (57.8%). Combining all three tumour markers raised the sensitivity to 63.9%. In the subgroup of patients with tissue HER2+ tumours, the sensitivity of HER2 increased to 55.6%. The best combination in this group was CEA/HER2 (66.7%). In the subgroup of patients with tissue HER2− tumours, CA 15-3 was significantly better. The best combination was CA 15-3/HER2 or CA 15-3/CEA with a sensitivity of 55.8% and 59.6%, respectively. Conclusions: The combination of several tumour markers enhances the sensitivity for detection of metastatic breast cancer. We recommend HER2 or the combination of CEA and HER2 in tissue HER2+ and CA 15-3 or the combination of CA 15-3 and CEA in tissue HER2−.
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Keywords {🔍}
cancer, breast, google, scholar, search, cea, serum, patients, antigen, tumor, clinical, markers, res, recurrence, tumour, carcinoembryonic, followup, marker, study, clin, sensitivity, early, diagnosis, levels, human, monitoring, biol, detection, metastatic, disease, combination, tissue, anticancer, results, chem, oncol, molina, filella, carcinoma, evaluation, reference, article, laboratory, receptor, lab, protein, diseases, biomarkers, eur, treat,
Topics {✒️}
multiplexed-based technologies underlines heparin-induced thrombocytopenia due intensive post-operative follow nucleotide-binding oligomerization domain triple-negative breast cancer serum albumin assay prospective longitudinal study ivan brandslund published/copyright ann christina pedersen monitor blood glucose serial serum values routine oncology setting biological fluids performance cell free dna human tumor marker elevated serum levels article breast cancer thyroid nodules serum liver disease development invasive breast cancer sensitive tumor marker retrospective 6-year study complementary tumor maker jonna skov madsen john libbey eurotext isobm td-4 workshop el-nass sa hemolysis-resistant reagent large health check china glycoproteomic identification sox17 dna methylation pseudothrombocytopenia delta check cost effective algorithm conditions legal notice serum tumor markers primary disseminated disease distant metastatic disease metastatic breast cancer breast cancer advances localised breast cancer recurrent breast cancer operable gastric cancer patricia diana sørensen erik hugger jacobsen research support played breast carcinoma tissues journal clinical chemistry lópez-bueno mj del campo jm breast cancer recurrences
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Schema {🗺️}
Article:
author:
type:Person
name:Ann Christina Pedersen
type:Person
name:Patricia Diana Sørensen
type:Person
name:Erik Hugger Jacobsen
type:Person
name:Jonna Skov Madsen
type:Person
name:Ivan Brandslund
editor:
audience:
datePublished:2013-07-01
headline:
keywords:keyword,keyword,keyword,keyword,keyword,keyword
isAccessibleForFree:
publisher:
type:Organization
name:De Gruyter
context:https://schema.org
name:Sensitivity of CA 15-3, CEA and serum HER2 in the early detection of recurrence of breast cancer
image:https://www.degruyterbrill.com/document/cover/journal_key/CCLM/thumbnail
url:https://doi.org/10.1515/cclm-2012-0488
Person:
name:Ann Christina Pedersen
name:Patricia Diana Sørensen
name:Erik Hugger Jacobsen
name:Jonna Skov Madsen
name:Ivan Brandslund
Organization:
name:De Gruyter
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