PMC . NCBI . NLM . NIH . GOV {
}
We are analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC4500905/.
Title:
Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier - PMC
Description:
The transcellular trafficking of iron from the blood into the brain interstitium depends on iron uptake proteins in the apical membrane of brain microvascular capillary endothelial cells and efflux proteins at the basolateral, abluminal membrane. In ...
Website Age:
27 years and 9 months (reg. 1997-10-02).
Title:
Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier - PMC
Description:
The transcellular trafficking of iron from the blood into the brain interstitium depends on iron uptake proteins in the apical membrane of brain microvascular capillary endothelial cells and efflux proteins at the basolateral, abluminal membrane. In ...
Website Age:
27 years and 9 months (reg. 1997-10-02).
Matching Content Categories {📚}
- Education
- Science
- Telecommunications
Content Management System {📝}
What CMS is pmc.ncbi.nlm.nih.gov built with?
Custom-built
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Traffic Estimate {📈}
What is the average monthly size of pmc.ncbi.nlm.nih.gov audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Pmc.ncbi.nlm.nih.gov Make Money? {💸}
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Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Pmc.ncbi.nlm.nih.gov might be cashing in, but we can't detect the method they're using.
Keywords {🔍}
iron, google, scholar, doi, pubmed, brain, fpn, bmvec, pmc, article, free, cell, expression, cells, hepcidin, efflux, surface, bbb, mccarthy, transport, kosman, protein, blood, role, regulation, disease, duodenal, app, alzheimers, ferroportin, barrier, uptake, scp, endothelial, ferroxidase, astrocytes, basolateral, activity, mice, proteins, dmt, mechanisms, membrane, transporter, transferrin, figure, hbmvec, trafficking, apical, precursor,
Topics {✒️}
pro-inflammatory cytokine-mediated ferroportin hp/cp double-mutant mice energy-producing redox reactions amyloid-β protein oligomer cerebral β-amyloid deposition β-amyloid precursor protein pmc beta search long-term pathophysiologic consequence n-lobe monoferric transferrins canonical tf-iron uptake bmvec–astrocyte signaling network normal irp-dependent repression redox-active iron formation iron exporter ferroportin/slc40a1 lipopolysaccharide-induced parkinsonian models signaling molecules interleukin-1β hepcidin-independent retrograde recycling disease peptide β-amyloid age-related macular degeneration transferring-bound iron uptake plasma membrane proton-adenosinetriphosphatases interleukin-1β induces ceruloplasmin astrocytes produce il-1β astrocyte-secreted soluble ceruloplasmin iron-binding glycoprotein transferrin iron-regulated ferric reductase intestinal iron-transporter expression iron-export ferroxidase activity duodenal iron-regulated transporter amyloid-β peptides il-1/il-1ra release leishmania-mediated inhibition amyloid precursor protein blood-brain barrier ryan redox active iron article provide ferroportin targeting peptide canonne-hergaux neuronal paracrine signaling iron-responsive element regulatory rna sequences multi-copper ferroxidase hephaestin retinal iron overload central nervous system dmt1-binding protein poly cerebral amyloid angiogenesis cerebral amyloid angiopathy double-edged sword decreased iron efflux hbmvec tf-iron uptake
Questions {❓}
- One insight into this role follows from the question, what is the physiologic function of amyloid precursor protein (APP)?
- Role of iron in neurotoxicity: a cause for concern in the elderly?
Social Networks {👍}(6)
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