
PMC . NCBI . NLM . NIH . GOV {
}
Title:
MiR-137 Targets Estrogen-Related Receptor Alpha and Impairs the Proliferative and Migratory Capacity of Breast Cancer Cells - PMC
Description:
ERRα is an orphan nuclear receptor emerging as a novel biomarker of breast cancer. Over-expression of ERRα in breast tumor is considered as a prognostic factor of poor clinical outcome. The mechanisms underlying the dysexpression of this nuclear ...
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27 years and 8 months (reg. 1997-10-02).
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Keywords {🔍}
errα, cancer, expression, cell, doi, breast, cells, level, target, pubmed, google, scholar, receptor, skbr, utr, transfection, data, analysis, mrna, gene, protein, tumor, mimics, ccne, mdamb, reporter, proliferation, pmc, cycle, estrogenrelated, human, fig, lines, article, figure, luciferase, assay, control, rna, free, activity, performed, line, treatment, site, microrna, genes, effect, alpha, wnt,
Topics {✒️}
estrogen-related receptor-gamma estrogen-related receptor alpha 5′-ccttcattctgttgagggcactgc-3′ q-β-actin forward 5′-caccaactgggacgacat-3′ q-β-actin reverse multiple-hormone response element estrogen receptor alpha estrogen-related receptor 3 erα-positive/her2-negative erα-negative/her2-positive cell-specific biological function dual-luciferase reporter system quantitative-real-time pcr sk-br-3 cell line poor-prognosis breast carcinoma erα-positive/her2-positive highly conserved target-sites orphan nuclear receptor her2-positive breast cancer tumorigenesis-related target genes estrogen receptor-positive mda-mb-231 cell line endocrine-responsive breast cancer reverse transcriptase m-mlv 100ng/ml cholera toxin 5′-ctgcagggcatagaggcagtgctctc-3′ q-esrra forward site-directed mutagenesis kit positive auto-regulatory loop rnu6b-small nuclear rna 5′-ggcccttgccaattcaga-3′ q-esrra reverse normal breast epithelial estrogen-related receptors 5′-cctccgctgcaacagacagaa-3′ q-wnt11 forward 5′-ggcctcgtgcagagcttct-3′ q-ccne1 forward pmc beta search 5′-tggccctgaaaggtcaagtctgta-3′ q-aco2 forward erbb2/her2 signaling pathway 5′-gcttgtgctttgccttcacttgga-3′ q-wnt11 reverse 5′-ctggacaaagcccgagcaaag-3′ q-ccne1 reverse ligand-independent transcriptional activation 5′-gatccacgagaccaacctgaagaa-3′ q-aco2 reverse sk-br-3 cells partly human breast carcinoma bioinformatics search employing estrogen signaling pathway sk-br-3 cells transfected brdu incorporation assay mda-mb-231 cells partly β-actin mrna expression real-time pcr reporter plasmid–“mir-137 target”
Questions {❓}
- However, besides at transcriptional level, are there any regulatory mechanisms at additional levels?
- Which cyclin E prevails as prognostic marker for breast cancer?
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