
PMC . NCBI . NLM . NIH . GOV {
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Title:
Progesterone receptor action: defining a role in breast cancer - PMC
Description:
The ovarian steroid hormones, estradiol and progesterone, and their nuclear receptors (estrogen receptor [ER] and progesterone receptor [PR]), are involved in breast cancer development. As ER-positive/PR-positive tumors progress, they are likely to ...
Website Age:
27 years and 8 months (reg. 1997-10-02).
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Keywords {🔍}
doi, breast, progesterone, cancer, pubmed, google, scholar, receptor, cells, mammary, cell, pmc, protein, signaling, article, free, development, human, gland, growth, receptors, estrogen, phosphorylation, hormone, prb, steroid, gene, proliferation, normal, expression, biol, mol, rapid, kinase, activation, epithelial, transcriptional, kinases, stem, models, action, genes, tumor, early, factors, factor, response, function, csrc, endocrinol,
Topics {✒️}
n-methyl-n-nitrosourea-induced n-terminal proline-rich region phosphatidylinositol 3-kinase/akt/mammalian target er-positive/pr-positive tumors progress long-label-retaining mammary cells er-positive/pr-positive breast cancers endocrine-resistant luminal b-type c-src-dependent sustained activation mainstream endocrine/er-based therapies fgf2-induced mammary hyperplasia label-retaining epithelial cells progestin/pr-induced autocrine signaling progesterone-induced side-branching induced anchorage-independent growth ]anthracene-induced mammary tumors growth factor-induced signaling egf-treated positive control er+/pr-null tumor phenotype progestin-induced epithelial proliferation pr-b-driven biology pmc beta search progesterone/pr-dependent paracrine factors significantly post-translationally modified upregulate growth-promoting genes er+pr+ck5+ cells comprise cyclin-dependent kinase inhibitors rapidly activating c-src patient/survivor-led groups largely employed er-positive cd44+ tumor-initiating cells src/p21ras/erk pathway epithelial-derived mammary alveoli progesterone-induced mec proliferation growth factor-driven suppression sr-specific gene signatures blocking pr-induced upregulation pr-induced paracrine factor sr-positive breast tumors er-centric experimental approaches c-src kinase upstream progestin-driven mammary cancer pr-driven tumors due apparently ‘pr-null’ tumors progestin-activated protein kinases nih/national cancer institute progestin-induced mapk levels c-src/erk pathway steroid receptor-driven biology hormone-refractory breast cancer n-terminally truncated version
Questions {❓}
- Cellular quiescence in mammary stem cells and breast tumor stem cells: got testable hypotheses?
- High hopes for RANKL: will the mouse model live up to its promise?
- Is the action of PRs in breast cancer a missed opportunity?
- Why study progesterone/PR in the breast?
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