PMC . NCBI . NLM . NIH . GOV {
}
We are analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC2930428/.
Title:
Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment - PMC
Description:
In several murine models of autoimmune arthritis, Th17 cells are the dominant initiators of inflammation. In human arthritis the majority of IL-17–secreting cells within the joint express a cytokine phenotype intermediate between Th17 and Th1. Here ...
Website Age:
27 years and 8 months (reg. 1997-10-02).
Title:
Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment - PMC
Description:
In several murine models of autoimmune arthritis, Th17 cells are the dominant initiators of inflammation. In human arthritis the majority of IL-17–secreting cells within the joint express a cytokine phenotype intermediate between Th17 and Th1. Here ...
Website Age:
27 years and 8 months (reg. 1997-10-02).
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🌠 Phenomenal Traffic: 5M - 10M visitors per month
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Keywords {🔍}
cells, doi, expression, arthritis, pubmed, google, scholar, synovial, fig, ifnγ, human, joint, populations, pmc, article, phenotype, rorc, patients, sorted, plasticity, free, population, site, vitro, inflamed, receptor, sfmc, immunol, cytokine, tgfβ, ccr, flow, cell, jia, enriched, disease, blood, show, vivo, shown, data, autoimmune, inflammatory, joints, control, detected, presence, levels, tcell, tcr,
Topics {✒️}
ifn-γ-specific capture assays pmc beta search anti-apoptotic bcl-xl live/dead discriminant dye topo-ta cloning strategy cd8+ t-cell expansions org/lookup/suppl/doi nod/scid recipient mice aryl hydrocarbon receptor t-cell receptor analysis human t-cell expansion t-cell receptor bv t-bet mrna expression tcr-β variable chain recombinant human ifn-γ capture cytokine-expressing cells patients coexpress ifn-γ cells coexpressing ifn-γ ifn-γ protein detected analyzed t-cell receptor cd161-ifn-γ+ populations cytokine-expressing synovial cd4+ regulate ifn-γ production th1 cytokine ifn-γ ifn-γ–secreting cd4+ direct submission article il-23r mrna expression proinflammatory th1/th0 cells cell contact-dependent mechanism serum-free medium platelet-depleted synovial supernatants transcription factor expression supporting information online pure il-17–secreting lineage cell il-6r expression ccr6-expressing th17 cells significantly higher levels full tcr sequences cytokine-producing cells gated full informed consent ifn-γ express sfmc il-23r expression th1 oligoclonal patterns coexpressing ifn-γ th17-mediated disease license information pmcid t-bet expression showing cd161 expression regulate ifn-γ express chemokine receptors
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