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Overview: Lipid Metabolism in the Tumor Microenvironment | SpringerLink
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The tumor microenvironment represents the dynamic network consisting of tumor cells, stromal cells, and multiple lineages of immune subsets. It is well recognized that metabolic crosstalk within the tumor microenvironment (TME) greatly shapes both the composition and...
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month download article/chapter convergent physiologyโdivergent pathophysiology regulation src/erk pathway myeloid-derived suppressor cells srebp-regulated lipid metabolism cell-intrinsic lysosomal lipolysis fatty acid metabolism targeting metastasis-initiating cells fatty acid synthase fatty acid carbon fatty acid synthesis breast cancer cells privacy choices/manage cookies lipid metabolism reprogramming device instant download rapid tumor growth antiangina drug perhexiline tumor cell growth chapter lipid metabolism targeting lipid metabolism cholesterol induces cd8 modulating cholesterol metabolism challenging current concepts enhanced lipid accumulation lianjun zhang cancer biol ther nature killer cells lipid-enriched environment infiltrated immune cells adaptive immune cells natural killer cells trends cell biol mol cell endocrinol chapter ma p38/p65 signaling tumor microenvironment chapter optimizing cancer treatment european economic area dynamic network consisting biochim biophys acta annu rev physiol pfkfb3-driven glycolysis immune suppressive phenotype agpat4/lpa axis high serum levels editor information editors tumor microenvironment represents tumor immune microenvironment dendritic cell dysfunction potential therapeutic target
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ScholarlyArticle:
headline:Overview: Lipid Metabolism in the Tumor Microenvironment
pageEnd:47
pageStart:41
image:https://media.springernature.com/w153/springer-static/cover/book/978-981-33-6785-2.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Lipid Metabolism in Tumor Immunity
isbn:
978-981-33-6785-2
978-981-33-6784-5
type:Book
publisher:
name:Springer Singapore
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Kaili Ma
affiliation:
name:Suzhou Institute of Systems Medicine
address:
name:Suzhou Institute of Systems Medicine, Suzhou, China
type:PostalAddress
type:Organization
name:Chinese Academy of Medical Sciences and Peking Union Medical College
address:
name:Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
type:PostalAddress
type:Organization
type:Person
name:Lianjun Zhang
affiliation:
name:Suzhou Institute of Systems Medicine
address:
name:Suzhou Institute of Systems Medicine, Suzhou, China
type:PostalAddress
type:Organization
name:Chinese Academy of Medical Sciences and Peking Union Medical College
address:
name:Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Tumor microenvironment, Lipid metabolism, Immunosuppression, Antitumor immunity, T cells
description:The tumor microenvironment represents the dynamic network consisting of tumor cells, stromal cells, and multiple lineages of immune subsets. It is well recognized that metabolic crosstalk within the tumor microenvironment (TME) greatly shapes both the composition and functionality of the infiltrated immune cells and therefore critically regulate the antitumor immunity. In general, most solid tumors are considered as lipid-enriched environment, which is beneficial for tumor cell growth and immune escape. Here we briefly summarize the effects of accumulated lipids on tumor cells and immune cells. We also discuss the possibility of targeting lipid metabolism within the TME and potential strategies for optimizing cancer treatment.
datePublished:2021
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name:Lipid Metabolism in Tumor Immunity
isbn:
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name:Suzhou Institute of Systems Medicine
address:
name:Suzhou Institute of Systems Medicine, Suzhou, China
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address:
name:Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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name:Suzhou Institute of Systems Medicine, Suzhou, China
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name:Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
name:Suzhou Institute of Systems Medicine, Suzhou, China
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