We are analyzing https://link.springer.com/chapter/10.1007/978-981-10-3233-2_23.

Title:
Runx3 in Immunity, Inflammation and Cancer | SpringerLink
Description:
In this chapter we summarize the pros and cons of the notion that Runx3 is a major tumor suppressor gene (TSG). Inactivation of TSGs in normal cells provides a viability/growth advantage that contributes cell-autonomously to cancer. More than a decade ago it was...
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Keywords {🔍}

pubmed, google, scholar, article, cas, cancer, central, runx, nature, cell, genetics, journal, gastric, susceptibility, cells, development, tumor, groner, levanon, human, genomewide, association, molecular, loci, expression, lung, disease, identifies, methylation, breast, negreanu, transcription, van, wang, mouse, dna, genes, ito, lotem, factor, study, kim, inflammation, gene, adenocarcinoma, genetic, research, chapter, immunity, medicine,

Topics {✒️}

neutrophil-derived il-1β impairs genome-wide meta-analysis increases transcription factors t-bet genome-wide association study genome-wide association studies runt-related transcription factor-2 month download article/chapter t-box proteins cooperate runt domain gene-family somatic copy-number alteration runx3 attenuates beta-catenin/ large-scale genetic study tgf-beta signaling tumour necrosis factor-alpha single-cell rna-seq k-ras activation generates large-scale epigenetic alterations methylation-specific dna microarray mmtv-pymt transgenic mice early-onset gastric carcinomas diffuse-type gastric cancer runx3-mediated transcriptional program association study revealed genome-wide analysis proliferation-dependent alterations promotes skin tumorigenesis cell-autonomous tumor suppression functional il-6 receptor tnf-alpha decreases intestinal intraepithelial lymphocytes immune-related loci east asians identifies lung cancer identifies genome-scale analysis cell stem cell privacy choices/manage cookies transcription factor mutated functional genomics reveals high-density genotyping runx transcription factors promotes tumor development reserve stem cells disease susceptibility loci alveolar macrophage-derived transcription factor runx2 multiple risk variants shared susceptibility locus rapamycin-dependent hyperproliferation runx1 transcription factor transcription factor runx3

Questions {❓}

ARID1A mutations in cancer: Another epigenetic tumor suppressor?
Runt-related transcription factors in human carcinogenesis: a friend or foe?

Schema {🗺️}

ScholarlyArticle:
      headline:Runx3 in Immunity, Inflammation and Cancer
      pageEnd:393
      pageStart:369
      image:https://media.springernature.com/w153/springer-static/cover/book/978-981-10-3233-2.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:RUNX Proteins in Development and Cancer
         isbn:
            978-981-10-3233-2
            978-981-10-3231-8
         type:Book
      publisher:
         name:Springer Singapore
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Joseph Lotem
            affiliation:
                  name:Weizmann Institute of Science
                  address:
                     name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ditsa Levanon
            affiliation:
                  name:Weizmann Institute of Science
                  address:
                     name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Varda Negreanu
            affiliation:
                  name:Weizmann Institute of Science
                  address:
                     name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Omri Bauer
            affiliation:
                  name:Weizmann Institute of Science
                  address:
                     name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shay Hantisteanu
            affiliation:
                  name:Weizmann Institute of Science
                  address:
                     name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Joseph Dicken
            affiliation:
                  name:Weizmann Institute of Science
                  address:
                     name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
                     type:PostalAddress
                  type:Organization
                  name:Compugen Ltd
                  address:
                     name:Compugen Ltd, Holon, Israel
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yoram Groner
            affiliation:
                  name:Weizmann Institute of Science
                  address:
                     name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Cancer, Immunity, Inflammation, RUNX3, Tumor suppressor gene
      description:In this chapter we summarize the pros and cons of the notion that Runx3 is a major tumor suppressor gene (TSG). Inactivation of TSGs in normal cells provides a viability/growth advantage that contributes cell-autonomously to cancer. More than a decade ago it was suggested that RUNX3 is involved in gastric cancer development, a postulate extended later to other epithelial cancers portraying RUNX3 as a major TSG. However, evidence that Runx3 is not expressed in normal gastric and other epithelia has challenged the RUNX3-TSG paradigm. In contrast, RUNX3 is overexpressed in a significant fraction of tumor cells in various human epithelial cancers and its overexpression in pancreatic cancer cells promotes their migration, anchorage-independent growth and metastatic potential. Moreover, recent high-throughput quantitative genome-wide studies on thousands of human samples of various tumors and new investigations of the role of Runx3 in mouse cancer models have unequivocally demonstrated that RUNX3 is not a bona fide cell-autonomous TSG. Importantly, accumulating data demonstrated that RUNX3 functions in control of immunity and inflammation, thereby indirectly influencing epithelial tumor development.
      datePublished:2017
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Book:
      name:RUNX Proteins in Development and Cancer
      isbn:
         978-981-10-3233-2
         978-981-10-3231-8
Organization:
      name:Springer Singapore
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Weizmann Institute of Science
      address:
         name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
         type:PostalAddress
      name:Weizmann Institute of Science
      address:
         name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
         type:PostalAddress
      name:Weizmann Institute of Science
      address:
         name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
         type:PostalAddress
      name:Weizmann Institute of Science
      address:
         name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
         type:PostalAddress
      name:Weizmann Institute of Science
      address:
         name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
         type:PostalAddress
      name:Weizmann Institute of Science
      address:
         name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
         type:PostalAddress
      name:Compugen Ltd
      address:
         name:Compugen Ltd, Holon, Israel
         type:PostalAddress
      name:Weizmann Institute of Science
      address:
         name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Joseph Lotem
      affiliation:
            name:Weizmann Institute of Science
            address:
               name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
               type:PostalAddress
            type:Organization
      name:Ditsa Levanon
      affiliation:
            name:Weizmann Institute of Science
            address:
               name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
               type:PostalAddress
            type:Organization
      name:Varda Negreanu
      affiliation:
            name:Weizmann Institute of Science
            address:
               name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
               type:PostalAddress
            type:Organization
      name:Omri Bauer
      affiliation:
            name:Weizmann Institute of Science
            address:
               name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
               type:PostalAddress
            type:Organization
      name:Shay Hantisteanu
      affiliation:
            name:Weizmann Institute of Science
            address:
               name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
               type:PostalAddress
            type:Organization
      name:Joseph Dicken
      affiliation:
            name:Weizmann Institute of Science
            address:
               name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
               type:PostalAddress
            type:Organization
            name:Compugen Ltd
            address:
               name:Compugen Ltd, Holon, Israel
               type:PostalAddress
            type:Organization
      name:Yoram Groner
      affiliation:
            name:Weizmann Institute of Science
            address:
               name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
      name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
      name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
      name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
      name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
      name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
      name:Compugen Ltd, Holon, Israel
      name:Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
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