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Title:
Sex-Dependent Role of Estrogen Sulfotransferase and Steroid Sulfatase in Metabolic Homeostasis | SpringerLink
Description:
Sulfonation and desulfation are two opposing processes that represent an important layer of regulation of estrogenic activity via ligand supplies. Enzymatic activities of families of enzymes, known as sulfotransferases and sulfatases, lead to structural and...
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Keywords {🔍}

pubmed, google, scholar, article, cas, journal, steroid, estrogen, central, sulfatase, sulfotransferase, endocrinology, human, metabolism, role, expression, molecular, biology, liver, research, metabolic, regulation, mice, gene, homeostasis, tissue, receptor, cancer, diabetes, obesity, obese, chapter, sulfotransferases, est, estrogens, adipose, endocrine, biological, biochemistry, jiang, medicine, activity, clinical, breast, mouse, reviews, european, sts, sciences, sulphatase,

Topics {✒️}

diabetogenic c57bl/ksj-db/db mice c57bl/ksj-db/db mice x-linked ichthyosis due formylglycine-generating enzyme – retention estrogen sulfotransferase-deficient mice oxidative stress-responsive gene tumor necrosis factor-alpha testis-specific estrogen sulfotransferase glucocorticoid receptor-mediated activation obese insulin-resistant subjects adipocyte-expressed antidiabetic target sts-mediated desulfation converts gender-specific expression privacy choices/manage cookies mauvais-jarvis editor information editors aberrant cholesterol transport ob/ob mice hl60 promyelocytic cells aberrant liver expression hepatic estrogen sulfotransferase sex-specific effect white blood cells human metabolic disease male obese mice sex-specific mechanisms chronic liver disease human breast cancer metabolic homeostasis chapter atherosclerotic human aorta nucleic acids research breast cancer growth gained increased attention polycystic ovary syndrome androgen-dependent cancers chemically reactive metabolites y-encoded pseudogene steroid sulfatase deficiency disrupt estrogen homeostasis sex-dependent role aryl hydrocarbon receptor sulfated steroid hormones estrogen sulfotransferase expression local tissue levels dexamethasone-induced hyperglycemia adipose tissue hypoxia visceral adipose tissue oxysterol 7alpha-hydroxylase lowers inflammatory cytokines estrogen-regulated gene

Schema {🗺️}

ScholarlyArticle:
      headline:Sex-Dependent Role of Estrogen Sulfotransferase and Steroid Sulfatase in Metabolic Homeostasis
      pageEnd:469
      pageStart:455
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-70178-3.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity
         isbn:
            978-3-319-70178-3
            978-3-319-70177-6
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Wojciech G. Garbacz
            affiliation:
                  name:University of Pittsburgh
                  address:
                     name:Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mengxi Jiang
            affiliation:
                  name:University of Pittsburgh
                  address:
                     name:Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wen Xie
            affiliation:
                  name:University of Pittsburgh
                  address:
                     name:Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Pittsburgh
                  address:
                     name:Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Estrogen Sulfotransferase, Steroid Sulfatase, Chronic Inflammatory Liver Disease, White Adipose Tissue, Constitutive Androstane Receptor (CAR)
      description:Sulfonation and desulfation are two opposing processes that represent an important layer of regulation of estrogenic activity via ligand supplies. Enzymatic activities of families of enzymes, known as sulfotransferases and sulfatases, lead to structural and functional changes of the steroids, thyroids, xenobiotics, and neurotransmitters. Estrogen sulfotransferase (EST) and steroid sulfatase (STS) represent negative and positive regulation of the estrogen activity, respectively. This is because EST-mediated sulfation deactivates estrogens, whereas STS-mediated desulfation converts the inactive estrogen sulfates to active estrogens. In addition to the known functions of estrogens, EST and STS in reproductive processes, regulation of estrogens and other signal molecules especially at the local tissue levels has gained increased attention in the context of metabolic disease in recent years. EST expression is detectable in the subcutaneous adipose tissue in both obese women and men, and the expression of EST is markedly induced in the livers of rodent models of obesity and type 2 diabetes. STS was found to be upregulated in patients with chronic inflammatory liver diseases. Interestingly, the tissue distribution and the transcriptional regulation of EST and STS exhibit obvious sex and species specificity. EST ablation produces completely opposite metabolic phenotype in female and male obese mice. Adipogenesis is also differentially regulated by EST in murine and human adipocytes. This chapter focuses on the recent progress in our understanding of the expression and regulation EST and STS in the context of metabolic homeostasis.
      datePublished:2017
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Book:
      name:Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity
      isbn:
         978-3-319-70178-3
         978-3-319-70177-6
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      name:Springer International Publishing
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Pittsburgh
      address:
         name:Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA
         type:PostalAddress
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         name:Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA
         type:PostalAddress
      name:University of Pittsburgh
      address:
         name:Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA
         type:PostalAddress
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      address:
         name:Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Wojciech G. Garbacz
      affiliation:
            name:University of Pittsburgh
            address:
               name:Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      name:Mengxi Jiang
      affiliation:
            name:University of Pittsburgh
            address:
               name:Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      name:Wen Xie
      affiliation:
            name:University of Pittsburgh
            address:
               name:Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA
               type:PostalAddress
            type:Organization
            name:University of Pittsburgh
            address:
               name:Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA
      name:Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA
      name:Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA
      name:Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA
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