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Title:
Mitochondria in Structural and Functional Cardiac Remodeling | SpringerLink
Description:
The heart must function continuously as it is responsible for both supplying oxygen and nutrients throughout the entire body, as well as for the transport of waste products to excretory organs. When facing either a physiological or pathological increase in cardiac...
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Topics {✒️}

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Questions {❓}

Hypertrophy of the heart: a new therapeutic target?

Schema {🗺️}

ScholarlyArticle:
      headline:Mitochondria in Structural and Functional Cardiac Remodeling
      pageEnd:306
      pageStart:277
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-55330-6.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Mitochondrial Dynamics in Cardiovascular Medicine
         isbn:
            978-3-319-55330-6
            978-3-319-55329-0
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Natalia Torrealba
            affiliation:
                  name:University of Chile
                  address:
                     name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pablo Aranguiz
            affiliation:
                  name:University of Chile
                  address:
                     name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Camila Alonso
            affiliation:
                  name:University of Chile
                  address:
                     name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Beverly A. Rothermel
            affiliation:
                  name:UT Southwestern Medical Center
                  address:
                     name:Cardiology Division, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Texas, Southwestern Medical Center
                  address:
                     name:Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Sergio Lavandero
            affiliation:
                  name:University of Chile
                  address:
                     name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
                     type:PostalAddress
                  type:Organization
                  name:University of Texas, Southwestern Medical Center
                  address:
                     name:Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Mitochondria, Heart, Cardiac remodeling, Sub-cellular remodeling
      description:The heart must function continuously as it is responsible for both supplying oxygen and nutrients throughout the entire body, as well as for the transport of waste products to excretory organs. When facing either a physiological or pathological increase in cardiac demand, the heart undergoes structural and functional remodeling as a means of adapting to increased workload. These adaptive responses can include changes in gene expression, protein composition, and structure of sub-cellular organelles involved in energy production and metabolism. Mitochondria are essential for cardiac function, as they supply the ATP necessary to support continuous cycles of contraction and relaxation. In addition, mitochondria carry out other important processes, including synthesis of essential cellular components, calcium buffering, and initiation of cell death signals. Not surprisingly, mitochondrial dysfunction has been linked to several cardiovascular disorders, including hypertension, cardiac hypertrophy, ischemia/reperfusion and heart failure. The present chapter will discuss how changes in mitochondrial cristae structure, fusion/fission dynamics, fatty acid oxidation, ATP production, and the generation of reactive oxygen species might impact cardiac structure and function, particularly in the context of pathological hypertrophy and fibrotic response. In addition, the mechanistic role of mitochondria in autophagy and programmed cell death of cardiomyocytes will be addressed. Here we will also review strategies to improve mitochondrial function and discuss their cardioprotective potential.
      datePublished:2017
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Book:
      name:Mitochondrial Dynamics in Cardiovascular Medicine
      isbn:
         978-3-319-55330-6
         978-3-319-55329-0
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Chile
      address:
         name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
         type:PostalAddress
      name:University of Chile
      address:
         name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
         type:PostalAddress
      name:University of Chile
      address:
         name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
         type:PostalAddress
      name:UT Southwestern Medical Center
      address:
         name:Cardiology Division, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of Texas, Southwestern Medical Center
      address:
         name:Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of Chile
      address:
         name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
         type:PostalAddress
      name:University of Texas, Southwestern Medical Center
      address:
         name:Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Natalia Torrealba
      affiliation:
            name:University of Chile
            address:
               name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
               type:PostalAddress
            type:Organization
      name:Pablo Aranguiz
      affiliation:
            name:University of Chile
            address:
               name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
               type:PostalAddress
            type:Organization
      name:Camila Alonso
      affiliation:
            name:University of Chile
            address:
               name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
               type:PostalAddress
            type:Organization
      name:Beverly A. Rothermel
      affiliation:
            name:UT Southwestern Medical Center
            address:
               name:Cardiology Division, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
            name:University of Texas, Southwestern Medical Center
            address:
               name:Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Sergio Lavandero
      affiliation:
            name:University of Chile
            address:
               name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
               type:PostalAddress
            type:Organization
            name:University of Texas, Southwestern Medical Center
            address:
               name:Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
      name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
      name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
      name:Cardiology Division, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, USA
      name:Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, USA
      name:Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile
      name:Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, USA
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