We are analyzing https://link.springer.com/chapter/10.1007/978-3-319-39406-0_2.

Title:
Clearance of Dying Cells by Phagocytes: Mechanisms and Implications for Disease Pathogenesis | SpringerLink
Description:
The efficient clearance of apoptotic cells is an evolutionarily conserved process crucial for homeostasis in multicellular organisms. The clearance involves a series of steps that ultimately facilitates the recognition of the apoptotic cell by the phagocytes and the...
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Topics {✒️}

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Questions {❓}

The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically?

Schema {🗺️}

ScholarlyArticle:
      headline:Clearance of Dying Cells by Phagocytes: Mechanisms and Implications for Disease Pathogenesis
      pageEnd:49
      pageStart:25
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-39406-0.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy
         isbn:
            978-3-319-39406-0
            978-3-319-39404-6
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Aaron M. Fond
            affiliation:
                  name:University of Virginia
                  address:
                     name:Center for Cell Clearance, and the Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kodi S. Ravichandran
            affiliation:
                  name:University of Virginia
                  address:
                     name:Center for Cell Clearance, and the Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Engulfment, Cell clearance, Apoptosis, Cancer, Immune tolerance
      description:The efficient clearance of apoptotic cells is an evolutionarily conserved process crucial for homeostasis in multicellular organisms. The clearance involves a series of steps that ultimately facilitates the recognition of the apoptotic cell by the phagocytes and the subsequent uptake and processing of the corpse. These steps include the phagocyte sensing of “find-me” signals released by the apoptotic cell, recognizing “eat-me” signals displayed on the apoptotic cell surface, and then intracellular signaling within the phagocyte to mediate phagocytic cup formation around the corpse and corpse internalization, and the processing of the ingested contents. The engulfment of apoptotic cells by phagocytes not only eliminates debris from tissues but also produces an anti-inflammatory response that suppresses local tissue inflammation. Conversely, impaired corpse clearance can result in loss of immune tolerance and the development of various inflammation-associated disorders such as autoimmunity, atherosclerosis, and airway inflammation but can also affect cancer progression. Recent studies suggest that the clearance process can also influence antitumor immune responses. In this review, we will discuss how apoptotic cells interact with their engulfing phagocytes to generate important immune responses, and how modulation of such responses can influence pathology.
      datePublished:2016
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      name:Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy
      isbn:
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         978-3-319-39404-6
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      name:Springer International Publishing
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      name:University of Virginia
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         name:Center for Cell Clearance, and the Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, USA
         type:PostalAddress
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      address:
         name:Center for Cell Clearance, and the Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, USA
         type:PostalAddress
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            address:
               name:Center for Cell Clearance, and the Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, USA
               type:PostalAddress
            type:Organization
      name:Kodi S. Ravichandran
      affiliation:
            name:University of Virginia
            address:
               name:Center for Cell Clearance, and the Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Center for Cell Clearance, and the Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, USA
      name:Center for Cell Clearance, and the Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, USA
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