We are analyzing https://link.springer.com/chapter/10.1007/978-3-319-20291-4_8.

Title:
The Diverse Effects of Complex Chromosome Rearrangements and Chromothripsis in Cancer Development | SpringerLink
Description:
In recent years, enormous progress has been made with respect to the identification of somatic mutations that contribute to cancer development. Mutation types range from small substitutions to large structural genomic rearrangements, including complex reshuffling of...
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Keywords {🔍}

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Topics {✒️}

month download article/chapter nonhomologous end-joining repair subgroup-specific structural variation recurrent vti1a-tcf7l2 fusion somatic copy-number alteration cancer-specific genomic rearrangements local defective-damage response breakage-fusion-bridge cycles treatment-naive ovarian cancer complex chromosomal rearrangements complex chromosome rearrangements exonic complex rearrangements dna replication timing campbell pj massively parallel sequencing somatically acquired rearrangements single catastrophic event privacy choices/manage cookies double-strand breaks variant ph translocations including complex reshuffling dna damage response complex karyotypic anomalies device instant download chronic myelogenous leukaemia multiple human cancers breakage-fusion-bridge dna lesions sequestered colorectal adenocarcinomas identifies editor information editors extrachromosomal double minutes increased genomic instability concerted genomic rearrangement complex chromosomal translocations prostate cancer genomes somatic structural variations somatic genomic rearrangement uniparental disomy identified longitudinal genomic analysis functional genomic analysis pan-cancer patterns nonhomologous repair mechanisms chronic myelogenous leukemia homogeneously staining regions acute lymphoblastic leukaemia de pagter & wigard complex rearrangements chromosomal instability inferred chapter chromosomal instability somatic dna alterations

Questions {❓}

Serial translocations or a concerted genomic rearrangement?

Schema {🗺️}

ScholarlyArticle:
      headline:The Diverse Effects of Complex Chromosome Rearrangements and Chromothripsis in Cancer Development
      pageEnd:193
      pageStart:165
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-20291-4.jpg
      genre:
         Medicine
         Medicine (R0)
      isPartOf:
         name:Chromosomal Instability in Cancer Cells
         isbn:
            978-3-319-20291-4
            978-3-319-20290-7
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Mirjam S. de Pagter
            affiliation:
                  name:University Medical Center Utrecht
                  address:
                     name:Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wigard P. Kloosterman
            affiliation:
                  name:University Medical Center Utrecht
                  address:
                     name:Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Chromothripsis, Chromosomal rearrangement, Next-generation paired-end sequencing, Mutation signatures
      description:In recent years, enormous progress has been made with respect to the identification of somatic mutations that contribute to cancer development. Mutation types range from small substitutions to large structural genomic rearrangements, including complex reshuffling of the genome. Sets of mutations in individual cancer genomes may show specific signatures, which can be provoked by both exogenous and endogenous forces. One of the most remarkable mutation patterns observed in human cancers involve massive rearrangement of just a few chromosomal regions. This phenomenon has been termed chromothripsis and appears widespread in a multitude of cancer types. Chromothripsis provides a way for cancer to rapidly evolve through a one-off massive change in genome structure as opposed to a gradual process of mutation and selection. This chapter focuses on the origin, prevalence and impact of chromothripsis and related complex genomic rearrangements during cancer development.
      datePublished:2015
      isAccessibleForFree:
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Book:
      name:Chromosomal Instability in Cancer Cells
      isbn:
         978-3-319-20291-4
         978-3-319-20290-7
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University Medical Center Utrecht
      address:
         name:Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
         type:PostalAddress
      name:University Medical Center Utrecht
      address:
         name:Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Mirjam S. de Pagter
      affiliation:
            name:University Medical Center Utrecht
            address:
               name:Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
      name:Wigard P. Kloosterman
      affiliation:
            name:University Medical Center Utrecht
            address:
               name:Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
      name:Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
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