
NCBI . NLM . NIH . GOV {
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Title[redir]:
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing - PMC
Description:
Human cancers often carry many somatically acquired genomic rearrangements, some of which may be implicated in cancer development. However, conventional strategies for characterizing rearrangements are laborious and low-throughput and have low ...
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Keywords {🔍}
ncih, rearrangements, number, reads, doi, cancer, copy, sequencing, fusion, pairedend, genome, dna, chromosome, genes, mapping, acquired, supplementary, genomic, gene, sequence, breakpoints, data, tandem, identified, pubmed, google, scholar, breakpoint, ends, germline, rearrangement, fig, amplicon, somatic, duplications, transcripts, size, region, pmc, regions, amplicons, cell, small, lines, mapped, amplified, article, fragments, line, found,
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uk/~pawefish/cell%20line%20catalogues/lung-cell-lines nci-h1770 nihms5231-supplement-acquired_and_germline_rearrangements_identified_in_nci-h1770 nci-h2171 nihms5231-supplement-acquired_and_germline_rearrangements_identified_in_nci-h2171 supplementary note nihms5231-supplement-supplementary_tables_1__4_and_5__supplementary_figures_1_and_2_and_supplementary_note uk/genetics/cgp/census/ massively parallel technology—incorporating small-cell lung cancer3 fitc sheep anti-digoxigenin biotinylated goat anti-streptavidin require paired-end sequencing chromosomal fragile site pmc beta search small-cell lung cancer mouse b-cell tumors methods paired-end sequencing genomeanalyzer paired-end flowcell dna-repair gene rad51c13 genuinely genome-wide screening show extensive variation paired-end reads showed sva repeat–mediated variants repeat-mediated germline polymorphisms paired-end reads spanning paired-end short reads paired-end read spanned paired-end reads mapping high-resolution structural detail supplementary material acquired massively parallel sequencing paired-end read yielded reliable modeling partial tandem duplication iterative binary segmentation eml4-alk fusion array painting reveals combining copy-number data pvt1-chd7 fusion gene b-cell line nci-h1770 genomic dna nci-h2171 amplicons implies paired-end ditags16 paired-end ditags fast search method partial tandem duplications created donor site paired-end data nci-h1770 somatic rearrangements full-length gene double-minute chromosomes nci-h1770 gave
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