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Title:
Mesenchymal Stem Cells in the Tumor Microenvironment | SpringerLink
Description:
The interactions between tumor cells and the non-malignant stromal and immune cells that make up the tumor microenvironment (TME) are critical to the pathophysiology of cancer. Mesenchymal stem cells (MSCs) are multipotent stromal stem cells found within most cancers...
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Schema {🗺️}

ScholarlyArticle:
      headline:Mesenchymal Stem Cells in the Tumor Microenvironment
      pageEnd:42
      pageStart:31
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-030-37184-5.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Tumor Microenvironment
         isbn:
            978-3-030-37184-5
            978-3-030-37183-8
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Huda Atiya
            affiliation:
                  name:Hillman Cancer Center, University of Pittsburgh
                  address:
                     name:Division of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Leonard Frisbie
            affiliation:
                  name:Hillman Cancer Center, University of Pittsburgh
                  address:
                     name:Division of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Catherine Pressimone
            affiliation:
                  name:University of Pittsburgh School of Medicine
                  address:
                     name:University of Pittsburgh School of Medicine, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lan Coffman
            affiliation:
                  name:Hillman Cancer Center, University of Pittsburgh
                  address:
                     name:Division of Hematology/Oncology, Division of Gynecologic Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Mesenchymal stem cells, Tumor microenvironment, Cancer, Immune response, Angiogenesis, Cancer stem cell, Stroma, Epithelial-mesenchymal transition
      description:The interactions between tumor cells and the non-malignant stromal and immune cells that make up the tumor microenvironment (TME) are critical to the pathophysiology of cancer. Mesenchymal stem cells (MSCs) are multipotent stromal stem cells found within most cancers and play a critical role influencing the formation and function of the TME. MSCs have been reported to support tumor growth through a variety of mechanisms including (i) differentiation into other pro-tumorigenic stromal components, (ii) suppression of the immune response, (iii) promotion of angiogenesis, (iv) enhancement of an epithelial-mesenchymal transition (EMT), (v) enrichment of cancer stem-like cells (CSC), (vi) increase in tumor cell survival, and (vii) promotion of tumor metastasis. In contrast, MSCs have also been reported to have antitumorigenic functions including (i) enhancement of the immune response, (ii) inhibition of angiogenesis, (iii) regulation of cellular signaling, and (iv) induction of tumor cell apoptosis. Although literature supporting both arguments exists, most studies point to MSCs acting in a cancer supporting role within the confines of the TME. Tumor-suppressive effects are observed when MSCs are used in higher ratios to tumor cells. Additionally, MSC function appears to be tissue type dependent and may rely on cancer education to reprogram a naïve MSC with antitumor effects into a cancer-educated or cancer-associated MSC (CA-MSC) which develops pro-tumorigenic function. Further work is required to delineate the complex crosstalk between MSCs and other components of the TME to accurately assess the impact of MSCs on cancer initiation, growth, and spread.
      datePublished:2020
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Book:
      name:Tumor Microenvironment
      isbn:
         978-3-030-37184-5
         978-3-030-37183-8
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Hillman Cancer Center, University of Pittsburgh
      address:
         name:Division of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
         type:PostalAddress
      name:Hillman Cancer Center, University of Pittsburgh
      address:
         name:Division of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
         type:PostalAddress
      name:University of Pittsburgh School of Medicine
      address:
         name:University of Pittsburgh School of Medicine, Pittsburgh, USA
         type:PostalAddress
      name:Hillman Cancer Center, University of Pittsburgh
      address:
         name:Division of Hematology/Oncology, Division of Gynecologic Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Huda Atiya
      affiliation:
            name:Hillman Cancer Center, University of Pittsburgh
            address:
               name:Division of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      name:Leonard Frisbie
      affiliation:
            name:Hillman Cancer Center, University of Pittsburgh
            address:
               name:Division of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      name:Catherine Pressimone
      affiliation:
            name:University of Pittsburgh School of Medicine
            address:
               name:University of Pittsburgh School of Medicine, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      name:Lan Coffman
      affiliation:
            name:Hillman Cancer Center, University of Pittsburgh
            address:
               name:Division of Hematology/Oncology, Division of Gynecologic Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Division of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
      name:Division of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
      name:University of Pittsburgh School of Medicine, Pittsburgh, USA
      name:Division of Hematology/Oncology, Division of Gynecologic Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
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