We are analyzing https://link.springer.com/chapter/10.1007/978-3-030-32656-2_9.

Title:
The Bone Microenvironment in Prostate Cancer Metastasis | SpringerLink
Description:
The propensity of prostate cancer cells to seed the skeleton and then progress into clinically relevant metastatic tumors is widely recognized and a major cause of morbidity and mortality for patients. The natural history of prostate adenocarcinoma most frequently...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

Farach-Carson, Prostate cancer and neuroendocrine differentiation: more neuronal, less endocrine?
Poupon, A ‘class action’ against the microenvironment: do cancer cells cooperate in metastasis?

Schema {🗺️}

ScholarlyArticle:
      headline:The Bone Microenvironment in Prostate Cancer Metastasis
      pageEnd:184
      pageStart:171
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-030-32656-2.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Prostate Cancer
         isbn:
            978-3-030-32656-2
            978-3-030-32655-5
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Anthony DiNatale
            affiliation:
                  name:Drexel University College of Medicine
                  address:
                     name:Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Thomas Jefferson University
                  address:
                     name:Program in Prostate Cancer, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alessandro Fatatis
            affiliation:
                  name:Drexel University College of Medicine
                  address:
                     name:Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Thomas Jefferson University
                  address:
                     name:Program in Prostate Cancer, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:
      description:The propensity of prostate cancer cells to seed the skeleton and then progress into clinically relevant metastatic tumors is widely recognized and a major cause of morbidity and mortality for patients. The natural history of prostate adenocarcinoma most frequently begins with a tumor diagnosed at a localized stage, which is successfully treated by surgical and/or radiation therapy modalities. A relevant percentage of patients are clinically cured but approximately 20–30% will develop biochemical signs of recurrence, which respond to the inhibition of androgen receptor (AR) signaling by hormone-deprivation and receptor antagonists, before the inevitable transition into castration-resistant prostate cancer (CRPC). This stage simultaneously presents with or is rapidly followed by secondary tumors, which involve the skeleton in more than 90% of cases (mCRPC). While generalization in clinical practice is always unwise, it is indisputable that bone-metastatic prostate cancer is virtually incurable. Decades of research have revealed that the tissue microenvironment provided by the bone marrow is as important as the cell-autonomous features of tumor cells in fostering the right conditions that lead to establishment and progression of metastatic tumors in the skeleton.
      datePublished:2019
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Book:
      name:Prostate Cancer
      isbn:
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         978-3-030-32655-5
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      name:Springer International Publishing
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Drexel University College of Medicine
      address:
         name:Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, USA
         type:PostalAddress
      name:Thomas Jefferson University
      address:
         name:Program in Prostate Cancer, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, USA
         type:PostalAddress
      name:Drexel University College of Medicine
      address:
         name:Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, USA
         type:PostalAddress
      name:Thomas Jefferson University
      address:
         name:Program in Prostate Cancer, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, USA
         type:PostalAddress
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Person:
      name:Anthony DiNatale
      affiliation:
            name:Drexel University College of Medicine
            address:
               name:Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Thomas Jefferson University
            address:
               name:Program in Prostate Cancer, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Alessandro Fatatis
      affiliation:
            name:Drexel University College of Medicine
            address:
               name:Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Thomas Jefferson University
            address:
               name:Program in Prostate Cancer, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, USA
      name:Program in Prostate Cancer, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, USA
      name:Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, USA
      name:Program in Prostate Cancer, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, USA
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