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Hematopoietic Stem Cell Heterogeneity | SpringerLink
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Hematopoietic stem cells (HSCs) maintain lifelong production of mature blood cells and regenerate the hematopoietic system after cytotoxic injury. Use of expanding cell surface marker panels and advanced functional analyses have revealed the presence of several...
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ScholarlyArticle:
headline:Hematopoietic Stem Cell Heterogeneity
pageEnd:211
pageStart:195
image:https://media.springernature.com/w153/springer-static/cover/book/978-3-030-24108-7.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Stem Cells Heterogeneity in Different Organs
isbn:
978-3-030-24108-7
978-3-030-24107-0
type:Book
publisher:
name:Springer International Publishing
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Roland Jurecic
affiliation:
name:Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
address:
name:Department of Microbiology & Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Hematopoietic stem cellsHematopoiesisHSC subsetsFunctional heterogeneityDifferentiation bias
description:Hematopoietic stem cells (HSCs) maintain lifelong production of mature blood cells and regenerate the hematopoietic system after cytotoxic injury. Use of expanding cell surface marker panels and advanced functional analyses have revealed the presence of several immunophenotypically different HSC subsets with distinct self-renewal and repopulating capacity and bias toward selective lineage differentiation. This chapter summarizes current understanding of the phenotypic and functional heterogeneity within the HSC pool, with emphasis on the immunophenotypes and functional features of several known HSC subsets, and their roles in steady-state and emergency hematopoiesis, and in aging. The chapter also highlights some of the future research directions to elucidate further the biology and function of different HSC subsets in health and disease states.
datePublished:2019
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