We are analyzing https://link.springer.com/chapter/10.1007/978-3-030-14366-4_7.

Title:
Heterogeneity of Colon Cancer Stem Cells | SpringerLink
Description:
Colorectal cancer (CRC) remains the fourth leading cause of cancer death worldwide. Cancer stem cells (CSCs) have attracted a great deal of interest because of their potential clinical implications in a range of cancers, including CRC. CSCs were initially considered...
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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:Heterogeneity of Colon Cancer Stem Cells
      pageEnd:126
      pageStart:115
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-030-14366-4.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Stem Cells Heterogeneity in Cancer
         isbn:
            978-3-030-14366-4
            978-3-030-14365-7
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Akihiro Hirata
            affiliation:
                  name:Life Science Research Center, Gifu University
                  address:
                     name:Division of Animal Experiment, Life Science Research Center, Gifu University, Gifu City, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yuichiro Hatano
            affiliation:
                  name:Gifu University Graduate School of Medicine
                  address:
                     name:Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Masayuki Niwa
            affiliation:
                  name:United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University
                  address:
                     name:Medical Science Division, United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu City, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Akira Hara
            affiliation:
                  name:Gifu University Graduate School of Medicine
                  address:
                     name:Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hiroyuki Tomita
            affiliation:
                  name:Gifu University Graduate School of Medicine
                  address:
                     name:Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Colorectal cancer, Cancer stem cell, Heterogneity, Cancer stem cell marker, Metastasis, Wnt signaling, Intestinal stem cell, Reversion, Plasticity, Tumor microenvironment
      description:Colorectal cancer (CRC) remains the fourth leading cause of cancer death worldwide. Cancer stem cells (CSCs) have attracted a great deal of interest because of their potential clinical implications in a range of cancers, including CRC. CSCs were initially considered to be cell populations with well-defined phenotypic and molecular characteristics. However, accumulating evidence suggests that CSCs represent a phenotypically and functionally heterogeneous population. Recent studies also demonstrate colorectal CSCs to be dynamic rather than static populations that are continuously altered by various extrinsic factors in addition to intrinsic cellular factors such as genetic and epigenetic alterations. Thus, CSCs do not represent a fixed target population any longer, and their heterogeneous and dynamic nature present a serious problem in establishing specific therapeutic strategies. This chapter summarizes past and current literature related to CSC population heterogeneity and dynamics in CRC tissues, including evidence of the presence of distinct CSC subpopulations and signaling pathways and intra- and extra-tumoral factors involved in the regulation of CSCs in cancer tissues.
      datePublished:2019
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Book:
      name:Stem Cells Heterogeneity in Cancer
      isbn:
         978-3-030-14366-4
         978-3-030-14365-7
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Life Science Research Center, Gifu University
      address:
         name:Division of Animal Experiment, Life Science Research Center, Gifu University, Gifu City, Japan
         type:PostalAddress
      name:Gifu University Graduate School of Medicine
      address:
         name:Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan
         type:PostalAddress
      name:United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University
      address:
         name:Medical Science Division, United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu City, Japan
         type:PostalAddress
      name:Gifu University Graduate School of Medicine
      address:
         name:Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan
         type:PostalAddress
      name:Gifu University Graduate School of Medicine
      address:
         name:Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan
         type:PostalAddress
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Person:
      name:Akihiro Hirata
      affiliation:
            name:Life Science Research Center, Gifu University
            address:
               name:Division of Animal Experiment, Life Science Research Center, Gifu University, Gifu City, Japan
               type:PostalAddress
            type:Organization
      name:Yuichiro Hatano
      affiliation:
            name:Gifu University Graduate School of Medicine
            address:
               name:Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan
               type:PostalAddress
            type:Organization
      name:Masayuki Niwa
      affiliation:
            name:United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University
            address:
               name:Medical Science Division, United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu City, Japan
               type:PostalAddress
            type:Organization
      name:Akira Hara
      affiliation:
            name:Gifu University Graduate School of Medicine
            address:
               name:Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan
               type:PostalAddress
            type:Organization
      name:Hiroyuki Tomita
      affiliation:
            name:Gifu University Graduate School of Medicine
            address:
               name:Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Division of Animal Experiment, Life Science Research Center, Gifu University, Gifu City, Japan
      name:Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan
      name:Medical Science Division, United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu City, Japan
      name:Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan
      name:Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan
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