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Evolutionary Conservation and Expression of Human RNA-Binding Proteins and Their Role in Human Genetic Disease | SpringerLink
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RNA-binding proteins (RBPs) are effectors and regulators of posttranscriptional gene regulation (PTGR). RBPs regulate stability, maturation, and turnover of all RNAs, often binding thousands of targets at many sites. The importance of RBPs is underscored by their...
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pubmed, google, scholar, cas, central, genet, rna, mutations, hum, cell, gene, nat, biol, mol, proteins, protein, human, syndrome, doijajhg, rev, mutation, disease, rnabinding, med, sci, doi, mitochondrial, res, mrna, function, splicing, binding, nature, cancer, type, genes, caused, biochem, patients, translation, science, rnas, expression, identification, proc, natl, acad, small, struct, structure,
Topics {✒️}
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Questions {❓}
- Andreou AZ, Klostermeier D (2013) The DEAD-box helicase eIF4A: paradigm or the odd one out?
- Auweter SD, Oberstrass FC, Allain FHT (2006) Sequence-specific binding of single-stranded RNA: is there a code for recognition?
- Bell JL, Wächter K, Mühleck B et al (2013) Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?
- Cléry A, Blatter M, Allain FHT (2008) RNA recognition motifs: boring?
- Köhn M, Pazaitis N, Hüttelmaier S (2013) Why YRNAs?
- Liu JM (2006) Ribosomes and marrow failure: coincidental association or molecular paradigm?
- Ruggero D, Pandolfi PP (2003) Does the ribosome translate cancer?
- Siomi MC, Mannen T, Siomi H (2010) How does the royal family of tudor rule the PIWI-interacting RNA pathway?
- Tessier M-C, Qu H-Q, Fréchette R et al (2006) Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?
- Thornton JE, Gregory RI (2012) How does Lin28 let-7 control development and disease?
Schema {🗺️}
ScholarlyArticle:
headline:Evolutionary Conservation and Expression of Human RNA-Binding Proteins and Their Role in Human Genetic Disease
pageEnd:55
pageStart:1
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-1221-6.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Systems Biology of RNA Binding Proteins
isbn:
978-1-4939-1221-6
978-1-4939-1220-9
type:Book
publisher:
name:Springer New York
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Stefanie Gerstberger
affiliation:
name:The Rockefeller University
address:
name:Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University, New York, USA
type:PostalAddress
type:Organization
type:Person
name:Markus Hafner
affiliation:
name:NIH National Institute of Arthritis and Musculoskeletal and Skin Disease
address:
name:Laboratory of Muscle Stem Cells and Gene Regulation, NIH National Institute of Arthritis and Musculoskeletal and Skin Disease, Bethesda, USA
type:PostalAddress
type:Organization
type:Person
name:Manuel Ascano
affiliation:
name:The Rockefeller University
address:
name:Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University, New York, USA
type:PostalAddress
type:Organization
type:Person
name:Thomas Tuschl
affiliation:
name:The Rockefeller University
address:
name:Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University, New York, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:RNA-binding domains, overview, RNA-binding proteins, tissue specificity, RNA-binding proteins, abundance, RNA-binding proteins, genetic diseases
description:RNA-binding proteins (RBPs) are effectors and regulators of posttranscriptional gene regulation (PTGR). RBPs regulate stability, maturation, and turnover of all RNAs, often binding thousands of targets at many sites. The importance of RBPs is underscored by their dysregulation or mutations causing a variety of developmental and neurological diseases. This chapter globally discusses human RBPs and provides a brief introduction to their identification and RNA targets. We review RBPs based on common structural RNA-binding domains, study their evolutionary conservation and expression, and summarize disease associations of different RBP classes.
datePublished:2014
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address:
name:Laboratory of Muscle Stem Cells and Gene Regulation, NIH National Institute of Arthritis and Musculoskeletal and Skin Disease, Bethesda, USA
type:PostalAddress
name:The Rockefeller University
address:
name:Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University, New York, USA
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name:Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University, New York, USA
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name:NIH National Institute of Arthritis and Musculoskeletal and Skin Disease
address:
name:Laboratory of Muscle Stem Cells and Gene Regulation, NIH National Institute of Arthritis and Musculoskeletal and Skin Disease, Bethesda, USA
type:PostalAddress
type:Organization
name:Manuel Ascano
affiliation:
name:The Rockefeller University
address:
name:Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University, New York, USA
type:PostalAddress
type:Organization
name:Thomas Tuschl
affiliation:
name:The Rockefeller University
address:
name:Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University, New York, USA
type:PostalAddress
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email:[email protected]
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name:Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University, New York, USA
name:Laboratory of Muscle Stem Cells and Gene Regulation, NIH National Institute of Arthritis and Musculoskeletal and Skin Disease, Bethesda, USA
name:Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University, New York, USA
name:Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University, New York, USA
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