We are analyzing https://link.springer.com/chapter/10.1007/978-1-4614-8289-5_5.

Title:
Gadd45 in the Liver: Signal Transduction and Transcriptional Mechanisms | SpringerLink
Description:
Injury and growth stimulation both remarkably increase the hepatic expression of Gadd45β. In liver cancer, promoter methylation frequently silences Gadd45β, demonstrating due to a suppressive function that is often proapoptotic. This contrasts with normal...
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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:Gadd45 in the Liver: Signal Transduction and Transcriptional Mechanisms
      pageEnd:80
      pageStart:69
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4614-8289-5.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Gadd45 Stress Sensor Genes
         isbn:
            978-1-4614-8289-5
            978-1-4614-8288-8
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jianmin Tian
            affiliation:
                  name:University of Pittsburgh School of Medicine
                  address:
                     name:Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Joseph Locker
            affiliation:
                  name:University of Pittsburgh School of Medicine
                  address:
                     name:Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Liver Regeneration, Partial Hepatectomy, Constitutive Androstane Receptor, Transcriptional Mechanism, Gadd45 Protein
      description:Injury and growth stimulation both remarkably increase the hepatic expression of Gadd45β. In liver cancer, promoter methylation frequently silences Gadd45β, demonstrating due to a suppressive function that is often proapoptotic. This contrasts with normal hepatocytes, where Gadd45β facilitates cell survival, growth, and proliferation. Gadd45β binds MKK7—downstream of TNFα and its receptors—to prevent this kinase from activating JNK2. Hence, the Gadd45b−/− genotype increases cell injury and decreases cell proliferation during liver regeneration (i.e., compensatory growth and proliferation). Liver hyperplasia (i.e., de novo growth and proliferation) is an alternate form of growth, caused by drugs that activate the nuclear receptor, CAR. As in regeneration, the Gadd45b−/− genotype considerably slows growth during hyperplasia. However, there is no injury and the slowing occurs because Gadd45β normally binds to CAR and activates its transcriptional stimulation. Thus, Gadd45β protects the liver through two entirely different processes: binding MKK7 to block damaging signal transduction or binding CAR to coactivate anabolic transcription.
      datePublished:2013
      isAccessibleForFree:
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Book:
      name:Gadd45 Stress Sensor Genes
      isbn:
         978-1-4614-8289-5
         978-1-4614-8288-8
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Pittsburgh School of Medicine
      address:
         name:Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, USA
         type:PostalAddress
      name:University of Pittsburgh School of Medicine
      address:
         name:Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Jianmin Tian
      affiliation:
            name:University of Pittsburgh School of Medicine
            address:
               name:Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      name:Joseph Locker
      affiliation:
            name:University of Pittsburgh School of Medicine
            address:
               name:Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, USA
      name:Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, USA
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