We are analyzing https://link.springer.com/article/10.1245/s10434-010-1373-9.

Title:
Significance of Lgr5+ve Cancer Stem Cells in the Colon and Rectum | Annals of Surgical Oncology
Description:
Although recent studies show that leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)+ve cells targeted by Wnt drive self-renewal in the skin and gastrointestinal organs, the clinicopathological significance of Lgr5+ve cancer stem cells (CSCs) of the colon remains to be elucidated. We studied the Wnt-targeted Lgr5 pathway in colorectal cancer (CRC). The expression of LGR5, c-MYC, p21CIP1/WAF1/CDKN1A, glutaminase (GLS), and miRs-23a and -23b (that target LGR5 and GLS) was evaluated by quantitative real-time reverse-transcription polymerase chain reaction (RT-PCR). The Lgr5 protein was evaluated by immunohistochemistry. The clinical relevance of gene expression in terms of patient survival was also evaluated. Overexpression of LGR5 was significantly associated with expression of c-MYC, p21CIP1/WAF1/CDKN1A, and GLS (p < 0.0001), and inversely associated with miR-23a/b (p < 0.05). Immunohistochemical analysis indicated that Lgr5 may be embedded in benign adenomas, localized at the tumor–host interface, and detectable over a broad area in established tumors. High level of LGR5 expression was associated with poor prognosis for CRC cancer patients (disease-free survival; p < 0.05). This study supports a significant role for LGR5 in the CSC hypothesis in CRC: (1) Lgr5+ve CSCs, presumably derived from normal stem cells in colonic crypts, proliferate, and the gene is overexpressed during CRC development; (2) LGR5 expression is associated with activation of Wnt pathway, including oncogenic c-MYC and high energy production via glutaminolysis; (3) LGR5 expression may be a poor prognostic factor for CRC patients. Further study of LGR5 should contribute to the development of CSC-based cancer therapeutics.
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article, cancer, google, scholar, pubmed, cas, stem, cells, phd, lgr, cell, expression, colorectal, nature, colon, human, research, facs, access, nat, privacy, cookies, content, lgrve, wnt, crc, cmyc, prognostic, marker, usa, publish, search, ishii, nishida, masaki, mori, molecular, proc, natl, acad, sci, oncol, identification, signaling, acute, analysis, data, information, log, journal,

Topics {✒️}

human colon-cancer-initiating cells beta-catenin/tcf-4 complex imposes tumor–host interface month download article/chapter cytoplasmic cd24 expression wnt/beta-catenin pathway activation cancer stem cells g-protein-coupled receptor 5 beta-catenin tcf signaling csc-based cancer therapeutics normal stem cells intestinal epithelium recapitulates multi-lineage differentiation capacity extracellular leucine-rich repeats colorectal cancer cells human colon cancer repressing stemness-inhibiting micrornas wnt-targeted lgr5 pathway leukemic stem cell facs & masaki mori md +ve cells targeted including oncogenic c-myc stem cells full article pdf initiating tumour growth related subjects phd & masaki mori md colorectal cancer patients de sousa mello van es jh beta-catenin signaling cancer cell metabolism privacy choices/manage cookies masaki mori md cancer cells e-cadherin expression acute myeloid leukemia potential human oncogene lgr5+ve cscs primitive hematopoietic cell nat rev cancer human acute leukemia leucine-rich repeat lgr5 marks cycling article takahashi human gastrointestinal system lgr5 protein malignant tumour progression single-cell cloning clin cancer res

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         description:Although recent studies show that leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)+ve cells targeted by Wnt drive self-renewal in the skin and gastrointestinal organs, the clinicopathological significance of Lgr5+ve cancer stem cells (CSCs) of the colon remains to be elucidated. We studied the Wnt-targeted Lgr5 pathway in colorectal cancer (CRC). The expression of LGR5, c-MYC, p21CIP1/WAF1/CDKN1A, glutaminase (GLS), and miRs-23a and -23b (that target LGR5 and GLS) was evaluated by quantitative real-time reverse-transcription polymerase chain reaction (RT-PCR). The Lgr5 protein was evaluated by immunohistochemistry. The clinical relevance of gene expression in terms of patient survival was also evaluated. Overexpression of LGR5 was significantly associated with expression of c-MYC, p21CIP1/WAF1/CDKN1A, and GLS (p < 0.0001), and inversely associated with miR-23a/b (p < 0.05). Immunohistochemical analysis indicated that Lgr5 may be embedded in benign adenomas, localized at the tumor–host interface, and detectable over a broad area in established tumors. High level of LGR5 expression was associated with poor prognosis for CRC cancer patients (disease-free survival; p < 0.05). This study supports a significant role for LGR5 in the CSC hypothesis in CRC: (1) Lgr5+ve CSCs, presumably derived from normal stem cells in colonic crypts, proliferate, and the gene is overexpressed during CRC development; (2) LGR5 expression is associated with activation of Wnt pathway, including oncogenic c-MYC and high energy production via glutaminolysis; (3) LGR5 expression may be a poor prognostic factor for CRC patients. Further study of LGR5 should contribute to the development of CSC-based cancer therapeutics.
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               name:Department of Molecular and Cellular Biology, Division of Molecular and Surgical Oncology, Kyushu University, Medical Institute of Bioregulation, Ohita, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Molecular and Cellular Biology, Division of Molecular and Surgical Oncology, Kyushu University, Medical Institute of Bioregulation, Ohita, Japan
      name:Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Molecular and Cellular Biology, Division of Molecular and Surgical Oncology, Kyushu University, Medical Institute of Bioregulation, Ohita, Japan
      name:Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Molecular and Cellular Biology, Division of Molecular and Surgical Oncology, Kyushu University, Medical Institute of Bioregulation, Ohita, Japan
      name:Department of Molecular and Cellular Biology, Division of Molecular and Surgical Oncology, Kyushu University, Medical Institute of Bioregulation, Ohita, Japan
      name:Department of Molecular and Cellular Biology, Division of Molecular and Surgical Oncology, Kyushu University, Medical Institute of Bioregulation, Ohita, Japan
      name:Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Molecular and Cellular Biology, Division of Molecular and Surgical Oncology, Kyushu University, Medical Institute of Bioregulation, Ohita, Japan
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