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Keywords {🔍}

pubmed, article, cells, google, scholar, stem, mesenchymal, cas, mscs, cell, central, mscsexo, exosomes, clinical, myocardial, wang, bone, httpsdoiorgs, treatment, therapeutic, patients, human, infarction, trial, res, tissue, umbilical, therapy, diseases, marrow, stromal, effects, bmmscs, cord, function, study, zhang, acute, effect, studies, culture, med, injury, disease, apoptosis, chen, potential, factors, ther, autologous,

Topics {✒️}

akt/gsk-3β/β-trcp/nrf2 axis regulating mir-20a-5p/e2f1/p73 signaling ngf-pi3k/akt/mtor signaling pathway adipose-derived stem/progenitor cells ad-mscs-exo carrying mir-93-5p exosome-shuttled mir-216a-5p mesenchymal stem-cell-derived exosomes activating s1p/sk1/s1pr1 signaling mir-19a/19b-loaded exosomes extracellular vesicle-derived mir-146a mesenchymal stem/stromal cells autologous bone marrow-derived umbilical cord-derived mscs hypoxia-preconditioned uc-mscs synoviocyte-derived inflammatory mediators garp-tgf-β index /r-induced cardiac injury intracoronary cardiosphere-derived cells lipopolysaccharide-induced lung injury stem cell-derived exosomes bone marrow-derived mscs bm-mscs-exo hypoxic preconditioning mir-132-3p priming enhances mir-138-5p/sirt1 axis human umbilical cord microrna-221/222/puma/ets-1 pathway [117] microrna-221/222/puma/ets-1 pathway umbilical cord-derived dental pulp-derived mscs neonatal tissue-derived msc p300-mediated h3k56 acetylation myocardial ischemia-reperfusion injury myocardial ischemia/reperfusion injury multipotent stromal cells mesenchymal progenitor cells adipose tissue-derived mscs activate pi3k/akt pathway /r-induced cardiomyocyte apoptosis multipotent stem cells cell-free therapy based human bone marrow human platelet lysate mesenchymal stromal cell mesenchymal stromal cells lamo-espinosa jm mscs-derived extracellular vesicles mscs-exo overexpressing islet-1 received intra-coronary injections mesenchymal stem cells stem cells derived

Questions {❓}

• Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis?
• Does transendocardial injection of mesenchymal stem cells improve myocardial function locally or globally?
• Mesenchymal Stem-Cell-Derived Exosomes as Novel Drug Carriers in Anti-Cancer Treatment: A Myth or Reality?

Schema {🗺️}

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      headline:Therapeutic effect of mesenchymal stem cells and their derived exosomes in diseases
      description:Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by their robust proliferative capacity, homing ability, differentiation potential, and low immunogenicity in vitro. MSCs can be isolated from a variety of tissues, primarily including but not limited to bone marrow, adipose tissue, umbilical cord, placenta, and dental pulp. Although there have been a large number of clinical studies on the treatment of diseases by MSCs and MSCs-derived exosomes (MSCs-EXO), the large-scale clinical application of MSCs and MSCs-EXO have been limited due to the heterogeneity of the results among various studies. This review provides a detailed description of the classification and characterization of MSCs and MSCs-EXO, as well as their extraction methods. Furthermore, this review elaborates on three key mechanisms of MSCs and MSCs-EXO: paracrine mechanisms, immunomodulatory and anti-inflammatory effects, as well as their promotion of tissue regeneration. This review also examines the role of MSCs and MSCs-EXO in cardiovascular diseases, neurological disorders, autoimmune diseases, musculoskeletal disorders, and other systemic diseases over the past five years, while discussing the challenges and difficulties associated with their clinical application. Finally, we systematically summarized and analyzed the potential causes of the various heterogeneous results currently observed. Additionally, we provided an in-depth discussion on the challenges and opportunities associated with the clinical translation of disease treatment approaches based on MSCs, MSCs-EXO, and engineered exosomes.
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      dateModified:2025-06-04T00:00:00Z
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         Exosome
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         Neurological disorders
         Autoimmune diseases
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