We are analyzing https://link.springer.com/article/10.1186/s13059-014-0453-8.

Title:
Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine | Genome Biology
Description:
The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.
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Keywords {🔍}

pubmed, cancer, tumor, article, google, scholar, cas, heterogeneity, evolution, mutations, driver, subclonal, central, events, sequencing, cell, clonal, resistance, therapy, nature, tumors, patients, multiple, subclones, analysis, clinical, cells, evolutionary, egfr, mutational, lung, intratumor, cancers, somatic, breast, kinase, number, genetic, mutation, research, drivers, precision, figure, copy, present, primary, treatment, braf, mechanisms, genomic,

Topics {✒️}

tyrosine kinase inhibitor-naive extracellular-signal-regulated kinase signaling anaplastic lymphoma kinase tyrosine kinase inhibitor chronic lymphocytic leukemia b-raf proto-oncogene university college london deciphering anti-tumour response combined raf/mek inhibition article download pdf recurrent high-grade gliomas significant false-positive rate small-cell lung cancer ultra-deep 500x coverage primary low-grade lesion independent risk factor high-throughput functional assessment deciphering anti-tumor response her2-positive breast cancer enrich low-frequency populations cancer research uk potential neo-antigenic repertoire alk-rearranged lung cancers recurrent high-grade relapse mutation-specific pcr strategies anti-egfr antibody therapy egfr inhibitor harbored multi-region sequencing approaches eml4-alk fusion gene advanced egfr mutation-positive serine/threonine kinase acute myeloid leukemia acute lymphoblastic leukemia her2-negative metastatic relapse braf-mutant melanoma patients significant anti-tumor efficacy hundred cancer-driver mutations braf wild-type population nik-zainal sa braf wild-type subclones heterogeneity search search neuroblastoma ras viral high-grade relapses article hiley protein-coding mutational burden braf wild-type cells molecularly stratified subgroups tracerx observational study multi-region sampling deciphering intratumor heterogeneity

Questions {❓}

Has the dominant subclone within a tumor outcompeted less fit minor subclones or is a new fitter subclonal population emerging (Figure 1)?
Should the treating physician switch systemic therapy, add a second systemic therapy to combat resistance, advocate locoregional approaches with surgery or radiotherapy, or monitor clinically insignificant progression and continue therapy with the caveat that non-responding lesions might act as an evolutionary sink that later contribute to more widespread progression?

Schema {🗺️}

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         headline:Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
         description:The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.
         datePublished:2014-08-27T00:00:00Z
         dateModified:2014-08-27T00:00:00Z
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            Plant Genetics and Genomics
            Microbial Genetics and Genomics
            Bioinformatics
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      headline:Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
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         Chronic Lymphocytic Leukemia
         Anaplastic Lymphoma Kinase
         Driver Mutation
         Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
         Animal Genetics and Genomics
         Human Genetics
         Plant Genetics and Genomics
         Microbial Genetics and Genomics
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         Evolutionary Biology
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            address:
               name:Cancer Research UK London Research Institute, Lincoln’s Inn Fields, London, UK
               type:PostalAddress
            type:Organization
            name:Institute of Cancer Research
            address:
               name:Institute of Cancer Research, London, UK
               type:PostalAddress
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      affiliation:
            name:University College London Cancer Institute
            address:
               name:University College London Cancer Institute, London, UK
               type:PostalAddress
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      name:Nicholas McGranahan
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               type:PostalAddress
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      name:Centre for Mathematics & Physics in the Life Science & Experimental Biology (CoMPLEX), University College London, London, UK
      name:Cancer Research UK London Research Institute, Lincoln’s Inn Fields, London, UK
      name:University College London Cancer Institute, London, UK

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