
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Clonal Architecture of Secondary Acute Myeloid Leukemia - PMC
Description:
The myelodysplastic syndromes are a group of hematologic disorders that often evolve into secondary acute myeloid leukemia (AML). The genetic changes that underlie progression from the myelodysplastic syndromes to secondary AML are not well ...
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Keywords {๐}
mutations, doi, myelodysplastic, aml, samples, syndromes, google, scholar, pubmed, secondary, cells, clonal, secondaryaml, leukemia, pmc, myelodysplasticsyndrome, progression, article, bone, marrow, supplementary, mds, saml, mutation, cancer, sequencing, subjects, clone, appendix, genome, data, fig, free, acute, genes, analysis, myeloid, somatic, founding, nature, recurrent, patients, clones, present, normal, stage, subject, number, cluster, genetic,
Topics {โ๏ธ}
calcium-binding epidermal-growth-factor extracellular membrane-bound molecule n-ras proto-oncogene sea-urchin sperm protein pmc beta search consensus splice-site regions putative single-nucleotide variants pmc copyright notice paired-end dna libraries solid-phase capture copy number-neutral loss paired-end reads generated secondary-aml samples diverged antecedent myelodysplastic-syndrome stage early-stage myelodysplastic syndromes paired myelodysplastic-syndrome sample colorectal-cancer cell lines x-chromosome gene stag2 single-gene resequencing studies eliminating disease-propagating cells secondary-aml genome contained secondary-amlโspecific clusters secondary-amlโspecific mutations med abstract background international scoring system acute myeloid leukemia [google scholar] 28 dominant secondary-aml clone hereditary cancer core amino acid position integrated genomic analyses myelodysplastic-syndrome founding clone genomic analysis core copy-number alterations splice-site mutations single-nucleotide-polymorphism tissue procurement core u2af1 splicing factor denotes interstitial deletions myeloid-tumor suppressor bone marrow appears bone marrow cellularity bone marrow obtained chromosome copy number copy-number correction chromosomal copy number copy-number alteration mutant allele burden mutant allele frequencies dna libraries prepared
Questions {โ}
- Are myelodysplastic syndromes โcancerโ?
- Is secondary leukemia an independent poor prognostic factor in acute myeloid leukemia?
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