We are analyzing https://link.springer.com/article/10.1186/s12943-021-01401-y.

Title:
An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks | Molecular Cancer
Description:
Background Adenosine deaminases acting on RNA (ADARs) modify many cellular RNAs by catalyzing the conversion of adenosine to inosine (A-to-I), and their deregulation is associated with several cancers. We recently showed that A-to-I editing is elevated in thyroid tumors and that ADAR1 is functionally important for thyroid cancer cell progression. The downstream effectors regulated or edited by ADAR1 and the significance of ADAR1 deregulation in thyroid cancer remain, however, poorly defined. Methods We performed whole transcriptome sequencing to determine the consequences of ADAR1 deregulation for global gene expression, RNA splicing and editing. The effects of gene silencing or RNA editing were investigated by analyzing cell viability, proliferation, invasion and subnuclear localization, and by protein and gene expression analysis. Results We report an oncogenic function for CDK13 in thyroid cancer and identify a new ADAR1-dependent RNA editing event that occurs in the coding region of its transcript. CDK13 was significantly over-edited (c.308A > G) in tumor samples and functional analysis revealed that this editing event promoted cancer cell hallmarks. Finally, we show that CDK13 editing increases the nucleolar abundance of the protein, and that this event might explain, at least partly, the global change in splicing produced by ADAR1 deregulation. Conclusions Overall, our data support A-to-I editing as an important pathway in cancer progression and highlight novel mechanisms that might be used therapeutically in thyroid and other cancers.
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Keywords {🔍}

cancer, pubmed, cdk, editing, adar, splicing, cells, article, thyroid, rna, google, scholar, cas, cell, fig, central, cal, analysis, genes, alternative, tpc, edited, events, atoi, observed, expression, data, gene, sicontrol, event, silencing, rnaseq, tumor, invasion, protein, nuclear, siadar, oncogenic, regulation, carcinoma, knockdown, global, localization, results, sites, lines, differential, progression, performed, proliferation,

Topics {✒️}

leibniz-institut dsmz-german collection article ramírez-moya cyclin-dependent kinase implicated article download pdf pid2019-105303rb-i00/aei/10 triple-negative breast cancer rna-seq variant calling regulates mir-200 activity adar1 steady-state expression rna-seq pipeline implemented innate immune response adenosine deaminases acting gov/geo/query/acc 75-bp paired-end reads direct cis-element editing stably expressing cdk13-wt rna-seq analysis showing high throughput rna-sequencing full access alternative pre-mrna splicing replicate rna-seq data main cancer hallmarks develop de novo hypoxia-induced tpm2 methylation adar1-mediated rna editing regulatory n-terminal region adar-mediated rna editing rna-seq results reveal comprehensive splice-site analysis sr-related protein implicated pre-mrna splicing factors cdk13 n-terminal region quantitative reverse transcription-pcr double-stranded rnas rna-sequencing sds-page inhibited colony formation regulates alternative splicing cis-acting elements sr protein-specific kinases human disease phenotypes rna-seq analysis demonstrated stably-transduced cdk13-wt post-transcriptional conversion cdk13 wt/edit ratio nucleic acids res adar1-dependent activity wt-cdk13 stimulated proliferation equivalent adar1-silenced cells adenosine deaminase acting privacy choices/manage cookies

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      name:Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) Instituto de Salud Carlos III (ISCIII), Madrid, Spain

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