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Title[redir]:
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data - PMC
Description:
Next-generation DNA sequencing (NGS) projects, such as the 1000 Genomes Project, are already revolutionizing our understanding of genetic variation among individuals. However, the massive data sets generated by NGSโthe 1000 Genome pilot alone ...
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Keywords {๐}
data, gatk, analysis, genome, sequencing, google, scholar, doi, pmc, pubmed, tools, reads, article, read, free, coverage, traversal, methods, reference, nextgeneration, walker, memory, base, framework, parallelization, single, information, locus, genomes, project, variation, common, processing, engine, genotyper, mapreduce, regions, dna, specific, snp, results, parallel, genotype, programming, development, calculations, distributed, shared, system, quality,
Topics {โ๏ธ}
terabasesโmake writing feature-rich log-odds score exceeds pmc beta search including quality-score recalibration production-grade multisample genotyper org/gsa/wiki/index local reference-guided assembly high-throughput sequence data false-positive snp calls automatic shared-memory parallelization production-quality sam library org/cgi/doi/10 called binary alignment/map sequence alignment/map format copy-number variation detection sequence read-based information massively parallel sequencing realistic read-mapping error references bentley dr large-scale sequencing projects geli text format martinez-alcantara hybrid capture resequencing international hapmap project active research area similar access patterns multiple-sample snp genotyping including read-group information parallel computing platforms burrows-wheeler transform generation dna sequencing low mapping quality mapping quality scores binary alignment version production resequencing facilities generation dna sequencers pmc disclaimer complex infrastructure needed common traversal type assembling dna nanoarrays solution hybrid selection read-based traversals provide high-resolution mapping functional programming philosophy functional programming paradigm single nucleotide polymorphism generation sequence aligners multiple-sequence realignment answer scientific questions local polynomial regression
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