We are analyzing https://link.springer.com/article/10.1007/s40265-018-0956-9.

Title:
Adult-Onset Still’s Disease: Molecular Pathophysiology and Therapeutic Advances | Drugs
Description:
Adult-onset Still’s disease (AOSD) is a rare inflammatory disorder of unknown etiology generally characterized by persistent high spiking fever, evanescent rash, and polyarthritis. The pathogenesis of AOSD is only partially known. The pivotal role of macrophage cell activation, which leads to T-helper 1 (Th1) cell cytokine activation, is now well-established in AOSD. Moreover, pro-inflammatory cytokines such as interleukin (IL)-1, -6, and -18 seem to play a key role in this disorder, giving rise to the development of new targeted therapies. For years, treatment of AOSD has been largely empirical, using nonsteroidal anti-inflammatory drugs, corticosteroids, and disease-modifying antirheumatic drugs. Patients with steroid- and methotrexate-refractory AOSD can now benefit from efficient and well-tolerated biologic agents such as IL-1, IL-6, and tumor necrosis factor-α antagonists.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Science
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

pubmed, disease, google, scholar, article, stills, cas, adultonset, rheumatol, adult, arthritis, patients, rheum, central, treatment, clin, chen, onset, refractory, interleukin, clinical, syndrome, systemic, ann, dis, juvenile, study, idiopathic, exp, efficacy, tocilizumab, med, case, sfriso, macrophage, activation, cytokine, res, lin, hsieh, anakinra, drugs, aosd, pathogenesis, therapy, rev, oxford, lee, response, van,

Topics {✒️}

month download article/chapter sara bindoli & paola galozzi macrophage-colony stimulating factor anti-cd20 monoclonal antibody nonsteroidal anti-inflammatory drugs steroidal anti-inflammatory drugs ifn-gamma-producing lymphocytes autologous stem-cell transplantation tnf-alpha-producing macrophages anti-il1 drug anakinra macrophage activation syndrome disease-modifying antirheumatic drugs article drugs aims full article pdf conventional treatment-refractory adult-onset van rossum ma line disease-modifying therapy il-1r inhibitor anakinra anti-interleukin-1 treatment distinguishes gerfaud-valentin privacy choices/manage cookies autoinflammatory disease reloaded anti-tnf-alpha active systemic features nlrp3 inflammasome van der veen high serum level liver biopsy illustrating open label treatment pro-inflammatory cytokines van damme-lombaerts long-acting inhibitor reduced perforin expression article sfriso anti-tnf switching connect tissue res hemophagocytic syndrome anti-interleukin-1 agents nold-petry ca european economic area 5ème édition paris nationwide epidemiological survey toxoplasma gondii infection intercellular adhesion molecule-1 serum cx3cl1 level sampalis js arthritis res ther arthritis care res rare inflammatory disorder tolerated biologic agents

Questions {❓}

Is anti-TNF switching in refractory Still’s disease safe and effective?
Targeting interleukin-1 b in CAPS (cryopyrin-associated periodic) syndromes: what did we learn?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Adult-Onset Still’s Disease: Molecular Pathophysiology and Therapeutic Advances
         description:Adult-onset Still’s disease (AOSD) is a rare inflammatory disorder of unknown etiology generally characterized by persistent high spiking fever, evanescent rash, and polyarthritis. The pathogenesis of AOSD is only partially known. The pivotal role of macrophage cell activation, which leads to T-helper 1 (Th1) cell cytokine activation, is now well-established in AOSD. Moreover, pro-inflammatory cytokines such as interleukin (IL)-1, -6, and -18 seem to play a key role in this disorder, giving rise to the development of new targeted therapies. For years, treatment of AOSD has been largely empirical, using nonsteroidal anti-inflammatory drugs, corticosteroids, and disease-modifying antirheumatic drugs. Patients with steroid- and methotrexate-refractory AOSD can now benefit from efficient and well-tolerated biologic agents such as IL-1, IL-6, and tumor necrosis factor-α antagonists.
         datePublished:2018-08-01T00:00:00Z
         dateModified:2018-08-01T00:00:00Z
         pageStart:1187
         pageEnd:1195
         sameAs:https://doi.org/10.1007/s40265-018-0956-9
         keywords:
            Pharmacotherapy
            Pharmacology/Toxicology
            Internal Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs40265-018-0956-9/MediaObjects/40265_2018_956_Fig1_HTML.png
         isPartOf:
            name:Drugs
            issn:
               1179-1950
               0012-6667
            volumeNumber:78
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer International Publishing
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Paolo Sfriso
               url:http://orcid.org/0000-0001-6432-7174
               affiliation:
                     name:University of Padova
                     address:
                        name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Sara Bindoli
               affiliation:
                     name:University of Padova
                     address:
                        name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Paola Galozzi
               affiliation:
                     name:University of Padova
                     address:
                        name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Adult-Onset Still’s Disease: Molecular Pathophysiology and Therapeutic Advances
      description:Adult-onset Still’s disease (AOSD) is a rare inflammatory disorder of unknown etiology generally characterized by persistent high spiking fever, evanescent rash, and polyarthritis. The pathogenesis of AOSD is only partially known. The pivotal role of macrophage cell activation, which leads to T-helper 1 (Th1) cell cytokine activation, is now well-established in AOSD. Moreover, pro-inflammatory cytokines such as interleukin (IL)-1, -6, and -18 seem to play a key role in this disorder, giving rise to the development of new targeted therapies. For years, treatment of AOSD has been largely empirical, using nonsteroidal anti-inflammatory drugs, corticosteroids, and disease-modifying antirheumatic drugs. Patients with steroid- and methotrexate-refractory AOSD can now benefit from efficient and well-tolerated biologic agents such as IL-1, IL-6, and tumor necrosis factor-α antagonists.
      datePublished:2018-08-01T00:00:00Z
      dateModified:2018-08-01T00:00:00Z
      pageStart:1187
      pageEnd:1195
      sameAs:https://doi.org/10.1007/s40265-018-0956-9
      keywords:
         Pharmacotherapy
         Pharmacology/Toxicology
         Internal Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs40265-018-0956-9/MediaObjects/40265_2018_956_Fig1_HTML.png
      isPartOf:
         name:Drugs
         issn:
            1179-1950
            0012-6667
         volumeNumber:78
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Paolo Sfriso
            url:http://orcid.org/0000-0001-6432-7174
            affiliation:
                  name:University of Padova
                  address:
                     name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Sara Bindoli
            affiliation:
                  name:University of Padova
                  address:
                     name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Paola Galozzi
            affiliation:
                  name:University of Padova
                  address:
                     name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Drugs
      issn:
         1179-1950
         0012-6667
      volumeNumber:78
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Padova
      address:
         name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
         type:PostalAddress
      name:University of Padova
      address:
         name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
         type:PostalAddress
      name:University of Padova
      address:
         name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Paolo Sfriso
      url:http://orcid.org/0000-0001-6432-7174
      affiliation:
            name:University of Padova
            address:
               name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Sara Bindoli
      affiliation:
            name:University of Padova
            address:
               name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
               type:PostalAddress
            type:Organization
      name:Paola Galozzi
      affiliation:
            name:University of Padova
            address:
               name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
      name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
      name:Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padua, Italy
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(286)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.01s.

LINK . SPRINGER . COM {}