We are analyzing https://link.springer.com/article/10.1007/s13770-021-00346-z.

Title:
The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis | Tissue Engineering and Regenerative Medicine
Description:
BACKGROUND Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are often resistant to ferroptosis via increased ferritin and impaired ferritinophagy. In this study, we investigated whether treatment with JQ1 could remove senescent cells by inducing ferroptosis. METHODS Senescence of human dermal fibroblasts was induced in vitro by treating the cells with bleomycin. The senolytic effects of JQ1 were evaluated using a SA-β gal assay, annexin V analysis, cell counting kit-8 assay, and qRT-PCR. Ferroptosis following JQ1 treatment was evaluated with qRT-PCR and BODIPY staining. RESULTS At a certain range of JQ1 concentrations, JQ1 treatment reduced the viability of bleomycin-treated cells (senescent cells) but did not reduce that of untreated cells (non-senescent cells), indicating that JQ1 treatment can selectively eliminate senescent cells. JQ1 treatment also decreased SASP expression only in senescent cells. Subsequently, JQ1 treatment reduced the expression of ferroptosis-resistance genes in senescent cells. JQ1 treatment induced lipid peroxidation in senescent cells but not in non-senescent cells. CONCLUSION The data indicate that JQ1 can eliminate senescent cells via ferroptosis. This study suggests ferroptosis as a new mechanism of senolytic therapy.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

pubmed, article, google, scholar, cas, cells, cell, central, ferroptosis, senescent, senescence, kim, cellular, senolytic, death, treatment, wang, aging, med, access, cancer, seoul, tissue, kang, ageing, nat, biol, iron, korea, privacy, cookies, content, research, jeon, byungsoo, human, therapy, protein, disease, data, information, publish, search, engineering, ferritinophagy, study, open, april, stem, inhibition,

Topics {✒️}

ros-activated gcn2-eif2alpha-atf4-xct pathway month download article/chapter magnetic nanoparticle-based approaches adipose-derived stem cells byung‐soo kim sa-β gal assay related subjects iron-dependent form article tissue engineering full article pdf lee tb jr increased brain exposure nonapoptotic cell death cell death dis cell death differ age-related diseases privacy choices/manage cookies iron-dependent yang ws acute myocardial infarction programmed cell senescence locally target therapy national research foundation cellular senescence contributes magnetic cell delivery hee jeon premature cell senescence p53 tumor suppressor ferroptosis-resistance genes alveolar epithelial cells sung pil kwon human dermal fibroblasts eliminate senescent cells senolytic therapy trends cell biol article log european economic area osteogenic differentiation capacity lucke-wold bp blood-brain barrier osteoporotic conditions influence murine ovarian follicles kirkland jl oncogenic ras pro-regenerative environment enhance tissue regeneration optimal wound healing bk21 graduate program animal experiments carried remove senescent cells

Questions {❓}

Senescent cells in cancer therapy: Friends or Foes?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis
         description:Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are often resistant to ferroptosis via increased ferritin and impaired ferritinophagy. In this study, we investigated whether treatment with JQ1 could remove senescent cells by inducing ferroptosis. Senescence of human dermal fibroblasts was induced in vitro by treating the cells with bleomycin. The senolytic effects of JQ1 were evaluated using a SA-β gal assay, annexin V analysis, cell counting kit-8 assay, and qRT-PCR. Ferroptosis following JQ1 treatment was evaluated with qRT-PCR and BODIPY staining. At a certain range of JQ1 concentrations, JQ1 treatment reduced the viability of bleomycin-treated cells (senescent cells) but did not reduce that of untreated cells (non-senescent cells), indicating that JQ1 treatment can selectively eliminate senescent cells. JQ1 treatment also decreased SASP expression only in senescent cells. Subsequently, JQ1 treatment reduced the expression of ferroptosis-resistance genes in senescent cells. JQ1 treatment induced lipid peroxidation in senescent cells but not in non-senescent cells. The data indicate that JQ1 can eliminate senescent cells via ferroptosis. This study suggests ferroptosis as a new mechanism of senolytic therapy.
         datePublished:2021-05-18T00:00:00Z
         dateModified:2021-05-18T00:00:00Z
         pageStart:841
         pageEnd:850
         sameAs:https://doi.org/10.1007/s13770-021-00346-z
         keywords:
            Cellular senescence
            Ferroptosis
            JQ1
            Senolytic drug
            Regenerative Medicine/Tissue Engineering
            Biomedical Engineering and Bioengineering
            Stem Cells
            Cell Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13770-021-00346-z/MediaObjects/13770_2021_346_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13770-021-00346-z/MediaObjects/13770_2021_346_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13770-021-00346-z/MediaObjects/13770_2021_346_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13770-021-00346-z/MediaObjects/13770_2021_346_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13770-021-00346-z/MediaObjects/13770_2021_346_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13770-021-00346-z/MediaObjects/13770_2021_346_Fig6_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13770-021-00346-z/MediaObjects/13770_2021_346_Fig7_HTML.png
         isPartOf:
            name:Tissue Engineering and Regenerative Medicine
            issn:
               2212-5469
               1738-2696
            volumeNumber:18
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Singapore
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Seokhyeong Go
               affiliation:
                     name:Seoul National University
                     address:
                        name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mikyung Kang
               affiliation:
                     name:Seoul National University
                     address:
                        name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sung Pil Kwon
               affiliation:
                     name:Seoul National University
                     address:
                        name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mungyo Jung
               affiliation:
                     name:Seoul National University
                     address:
                        name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ok Hee Jeon
               affiliation:
                     name:Korea University of College of Medicine
                     address:
                        name:Department of Biomedical Sciences, BK21 Graduate Program, Korea University of College of Medicine, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Byung‐Soo Kim
               url:http://orcid.org/0000-0001-5210-7430
               affiliation:
                     name:Seoul National University
                     address:
                        name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:Seoul National University
                     address:
                        name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:Seoul National University
                     address:
                        name:Institute of Chemical Processes, Institute of Engineering Research, and BioMAX, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis
      description:Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are often resistant to ferroptosis via increased ferritin and impaired ferritinophagy. In this study, we investigated whether treatment with JQ1 could remove senescent cells by inducing ferroptosis. Senescence of human dermal fibroblasts was induced in vitro by treating the cells with bleomycin. The senolytic effects of JQ1 were evaluated using a SA-β gal assay, annexin V analysis, cell counting kit-8 assay, and qRT-PCR. Ferroptosis following JQ1 treatment was evaluated with qRT-PCR and BODIPY staining. At a certain range of JQ1 concentrations, JQ1 treatment reduced the viability of bleomycin-treated cells (senescent cells) but did not reduce that of untreated cells (non-senescent cells), indicating that JQ1 treatment can selectively eliminate senescent cells. JQ1 treatment also decreased SASP expression only in senescent cells. Subsequently, JQ1 treatment reduced the expression of ferroptosis-resistance genes in senescent cells. JQ1 treatment induced lipid peroxidation in senescent cells but not in non-senescent cells. The data indicate that JQ1 can eliminate senescent cells via ferroptosis. This study suggests ferroptosis as a new mechanism of senolytic therapy.
      datePublished:2021-05-18T00:00:00Z
      dateModified:2021-05-18T00:00:00Z
      pageStart:841
      pageEnd:850
      sameAs:https://doi.org/10.1007/s13770-021-00346-z
      keywords:
         Cellular senescence
         Ferroptosis
         JQ1
         Senolytic drug
         Regenerative Medicine/Tissue Engineering
         Biomedical Engineering and Bioengineering
         Stem Cells
         Cell Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13770-021-00346-z/MediaObjects/13770_2021_346_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13770-021-00346-z/MediaObjects/13770_2021_346_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13770-021-00346-z/MediaObjects/13770_2021_346_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13770-021-00346-z/MediaObjects/13770_2021_346_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13770-021-00346-z/MediaObjects/13770_2021_346_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13770-021-00346-z/MediaObjects/13770_2021_346_Fig6_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13770-021-00346-z/MediaObjects/13770_2021_346_Fig7_HTML.png
      isPartOf:
         name:Tissue Engineering and Regenerative Medicine
         issn:
            2212-5469
            1738-2696
         volumeNumber:18
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Singapore
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Seokhyeong Go
            affiliation:
                  name:Seoul National University
                  address:
                     name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mikyung Kang
            affiliation:
                  name:Seoul National University
                  address:
                     name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sung Pil Kwon
            affiliation:
                  name:Seoul National University
                  address:
                     name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mungyo Jung
            affiliation:
                  name:Seoul National University
                  address:
                     name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ok Hee Jeon
            affiliation:
                  name:Korea University of College of Medicine
                  address:
                     name:Department of Biomedical Sciences, BK21 Graduate Program, Korea University of College of Medicine, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Byung‐Soo Kim
            url:http://orcid.org/0000-0001-5210-7430
            affiliation:
                  name:Seoul National University
                  address:
                     name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Seoul National University
                  address:
                     name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Seoul National University
                  address:
                     name:Institute of Chemical Processes, Institute of Engineering Research, and BioMAX, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Tissue Engineering and Regenerative Medicine
      issn:
         2212-5469
         1738-2696
      volumeNumber:18
Organization:
      name:Springer Singapore
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Seoul National University
      address:
         name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Korea University of College of Medicine
      address:
         name:Department of Biomedical Sciences, BK21 Graduate Program, Korea University of College of Medicine, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Institute of Chemical Processes, Institute of Engineering Research, and BioMAX, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Seokhyeong Go
      affiliation:
            name:Seoul National University
            address:
               name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Mikyung Kang
      affiliation:
            name:Seoul National University
            address:
               name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Sung Pil Kwon
      affiliation:
            name:Seoul National University
            address:
               name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Mungyo Jung
      affiliation:
            name:Seoul National University
            address:
               name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Ok Hee Jeon
      affiliation:
            name:Korea University of College of Medicine
            address:
               name:Department of Biomedical Sciences, BK21 Graduate Program, Korea University of College of Medicine, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Byung‐Soo Kim
      url:http://orcid.org/0000-0001-5210-7430
      affiliation:
            name:Seoul National University
            address:
               name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:Seoul National University
            address:
               name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:Seoul National University
            address:
               name:Institute of Chemical Processes, Institute of Engineering Research, and BioMAX, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
      name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
      name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
      name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
      name:Department of Biomedical Sciences, BK21 Graduate Program, Korea University of College of Medicine, Seoul, Republic of Korea
      name:Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, Republic of Korea
      name:School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
      name:Institute of Chemical Processes, Institute of Engineering Research, and BioMAX, Seoul National University, Seoul, Republic of Korea
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(209)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Particles.js
Prism.js

CDN Services {📦}

Crossref

4.74s.

LINK . SPRINGER . COM {}