We are analyzing https://link.springer.com/article/10.1007/s13258-020-00948-2.

Title:
Comprehensive analysis of the expression and prognosis for TFAP2 in human lung carcinoma | Genes & Genomics
Description:
Background The TFAP2 family of transcription factors, regulating gene expression related to vertebrate evolution, have been studied extensively in human cancer. However, the distinct roles of each TFAP2 in the expression and prognostic significance of lung carcinoma have not been elucidated yet. Objective This study is aimed to identify the mRNA expression and prognostic value of TFAP2 family in human lung cancer. Methods The transcriptional and survival data of TFAP2s in patients with lung cancer were obtained via ONCOMINE, LinkedOmics, GEPIA, cBioPortal, Kaplan–Meier Plotter and Human Protein Atlas databases. Results The results showed that expression levels of TFAP2A and TFAP2C were higher in lung adenocarcinoma and squamous cell carcinoma tissues than in normal lung tissues, whereas no difference was found in the TFAP2B expression level. TFAP2A was related to an unfavorable overall survival in lung cancer and its upregulation was significantly related to the overall survival in patients with smoking, non-chemotherapy and non-radiotherapy. Conclusion This study implied that TFAP2A was a reliable prognostic factor, which could be a potential marker for improving survival and prognostic accuracy of lung cancer patients.
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Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, lung, central, expression, zhao, transcription, chen, zhang, data, human, carcinoma, adenocarcinoma, factor, res, gene, china, analysis, survival, cell, genes, cheng, linyong, study, wang, sichuan, prognosis, tfap, caiqi, tfapa, tfapb, access, breast, oncol, university, privacy, cookies, content, information, research, related, prognostic, apalpha, sci, kang, kim,

Topics {✒️}

egfr/kras/alk-negative lung adenocarcinomas month download article/chapter epithelial-mesenchymal transition tfap2c-mediated upregulation post-doctor research project ap-2gamma transcription factor interactome-transcriptome analysis reveals ap-2alpha transcription factor transcription factor ap-2alpha transcription factor ap-2beta activator protein-2alpha expression large-scale expression profiling carcinogen-induced murine model integrated data-mining platform analyzing multi-omics data gene expression-based classification full article pdf multi-institutional validation analysis squamous cell carcinoma epithelial ovarian cancer privacy choices/manage cookies normal lung tissues complex cancer genomics linyong zhao declare human lung carcinoma related subjects article cheng west china hospital west china college human lung adenocarcinoma lung adenocarcinoma development human lung cancer vegf/pedf signaling breast cancer cells primary gene targets transcription factors reliable prognostic factor colon cancer cells ovarian cancer cells genes differentially expressed cai-qi cheng human pulmonary adenocarcinoma ap-2alpha results european economic area kaplan–meier plotter neonatal anthropometric parameters d'amico ta differential relapse patterns patent ductus arteriosus bunn pa jr

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