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We began analyzing https://www.nature.com/articles/6691146, but it redirected us to https://www.nature.com/articles/6691146. The analysis below is for the second page.

Title[redir]:
Expression of transcription factor AP-2α predicts survival in epithelial ovarian cancer | British Journal of Cancer
Description:
The 52-kDa activator protein (AP)-2 is a DNA-binding transcription factor which has been reported to have growth inhibitory effects in cancer cell lines and in human tumours. In this study the expression of AP-2α was analysed in 303 epithelial ovarian carcinomas by immunohistochemistry (IHC) with a polyclonal AP-2α antibody and its mRNA status was determined by in situ hybridization (ISH) and reverse transcriptase-polymerase chain reaction (RT-PCR). The immunohistochemical expression of AP-2α was correlated with clinicopathological variables, p21/WAF1 protein expression and survival. In normal ovaries, epithelial cells expressed AP-2α protein only in the cytoplasm. In carcinomas nuclear AP-2α expression was observed in 28% of the cases although cytoplasmic expression was more common (51%). The expression of AP-2α varied according to the histological subtype and differentiation. AP-2α and p21/WAF1 expressions did not correlate with each other. Both in univariate (P = 0.002) and multivariate analyses (relative risks (RR) 1.6, 95% confidence interval (CI) 1.13–2.18, P = 0.007) the high cytoplasmic AP-2α expression favoured the overall survival. In contrast, the nuclear AP-2α expression combined with low cytoplasmic expression increased the risk of dying of ovarian cancer (RR = 2.10, 95% CI 1.13–3.83, P = 0.018). The shift in the expression pattern of AP-2α (nuclear vs cytoplasmic) in carcinomas points out to the possibility that this transcription factor may be used by oncogenes in certain histological subtypes. Based on the mRNA analyses, the incomplete expression and translation of AP-2α in ovarian cancer may be due to post-transcriptional regulation. © 2000 Cancer Research Campaign

Matching Content Categories {📚}

  • Education
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Content Management System {📝}

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Custom-built

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Traffic Estimate {📈}

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🏙️ Massive Traffic: 50M - 100M visitors per month


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Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, expression, transcription, nature, factor, apα, cell, kuopio, human, central, ovarian, university, protein, gene, epithelial, kellokoski, content, kosma, cytoplasmic, biol, williams, department, cookies, open, survival, regulation, genes, breast, privacy, data, journal, access, anttila, mitchell, pwaf, research, prognostic, hurst, colorectal, carcinoma, factors, tjian, hospital, box, fin,

Topics {✒️}

nature portfolio privacy policy cancer research advertising nature 329 nature 325 nature social media cell-type-specific transcription factor 0/ reprints dna-binding transcription factor polyclonal ap-2α antibody ap-2α/γ targets trans-acting elements mediate phorbol ester-inducible enhancer epidermal-spesific gene expression c-myc activate expression p21/waf1 protein expression ccaat/enhancer binding protein enhancer-binding protein ap-2 figo cancer committee permissions epithelial gene expression p21/waf1 expression personal data p21/waf1 expressions transcription factor ap-2 epithelial ovarian cancer ap-2α varied data protection tcga data bar-eli el-deiry ws c-erbb-2 overexpression e-cadherin gene epithelial tumour progression human proenkephalin gene human metallothionein gene privacy human ovarian cancer explore content ap-2 transcription factors growth inhibitory effects signal-transduction pathways human colorectal carcinoma pennsylvania state university human ovarian carcinoma journals search log cervical intraepithelial neoplasia cancer cell lines

Schema {🗺️}

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         headline:Expression of transcription factor AP-2α predicts survival in epithelial ovarian cancer
         description:The 52-kDa activator protein (AP)-2 is a DNA-binding transcription factor which has been reported to have growth inhibitory effects in cancer cell lines and in human tumours. In this study the expression of AP-2α was analysed in 303 epithelial ovarian carcinomas by immunohistochemistry (IHC) with a polyclonal AP-2α antibody and its mRNA status was determined by in situ hybridization (ISH) and reverse transcriptase-polymerase chain reaction (RT-PCR). The immunohistochemical expression of AP-2α was correlated with clinicopathological variables, p21/WAF1 protein expression and survival. In normal ovaries, epithelial cells expressed AP-2α protein only in the cytoplasm. In carcinomas nuclear AP-2α expression was observed in 28% of the cases although cytoplasmic expression was more common (51%). The expression of AP-2α varied according to the histological subtype and differentiation. AP-2α and p21/WAF1 expressions did not correlate with each other. Both in univariate (P = 0.002) and multivariate analyses (relative risks (RR) 1.6, 95% confidence interval (CI) 1.13–2.18, P = 0.007) the high cytoplasmic AP-2α expression favoured the overall survival. In contrast, the nuclear AP-2α expression combined with low cytoplasmic expression increased the risk of dying of ovarian cancer (RR = 2.10, 95% CI 1.13–3.83, P = 0.018). The shift in the expression pattern of AP-2α (nuclear vs cytoplasmic) in carcinomas points out to the possibility that this transcription factor may be used by oncogenes in certain histological subtypes. Based on the mRNA analyses, the incomplete expression and translation of AP-2α in ovarian cancer may be due to post-transcriptional regulation. © 2000 Cancer Research Campaign
         datePublished:2000-05-23T00:00:00Z
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      headline:Expression of transcription factor AP-2α predicts survival in epithelial ovarian cancer
      description:The 52-kDa activator protein (AP)-2 is a DNA-binding transcription factor which has been reported to have growth inhibitory effects in cancer cell lines and in human tumours. In this study the expression of AP-2α was analysed in 303 epithelial ovarian carcinomas by immunohistochemistry (IHC) with a polyclonal AP-2α antibody and its mRNA status was determined by in situ hybridization (ISH) and reverse transcriptase-polymerase chain reaction (RT-PCR). The immunohistochemical expression of AP-2α was correlated with clinicopathological variables, p21/WAF1 protein expression and survival. In normal ovaries, epithelial cells expressed AP-2α protein only in the cytoplasm. In carcinomas nuclear AP-2α expression was observed in 28% of the cases although cytoplasmic expression was more common (51%). The expression of AP-2α varied according to the histological subtype and differentiation. AP-2α and p21/WAF1 expressions did not correlate with each other. Both in univariate (P = 0.002) and multivariate analyses (relative risks (RR) 1.6, 95% confidence interval (CI) 1.13–2.18, P = 0.007) the high cytoplasmic AP-2α expression favoured the overall survival. In contrast, the nuclear AP-2α expression combined with low cytoplasmic expression increased the risk of dying of ovarian cancer (RR = 2.10, 95% CI 1.13–3.83, P = 0.018). The shift in the expression pattern of AP-2α (nuclear vs cytoplasmic) in carcinomas points out to the possibility that this transcription factor may be used by oncogenes in certain histological subtypes. Based on the mRNA analyses, the incomplete expression and translation of AP-2α in ovarian cancer may be due to post-transcriptional regulation. © 2000 Cancer Research Campaign
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         prognosis
         AP-2α
         p21/WAF1
         Biomedicine
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         Cancer Research
         Epidemiology
         Molecular Medicine
         Oncology
         Drug Resistance
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Social Networks {👍}(1)

External Links {🔗}(264)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
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Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
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Name Servers:

  • josh.ns.cloudflare.com
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CDN Services {📦}

  • Crossref

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