We are analyzing https://link.springer.com/article/10.1007/s12282-012-0357-y.

Title:
Prognostic significance of NANOG and KLF4 for breast cancer | Breast Cancer
Description:
Background Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. The aim of the present study was to examine the relationship between the expression of iPS cell-inducing factors and the prognosis of breast cancer patients. Methods In 100 breast cancer patients, the expression of c-MYC, KLF4, NANOG, OCT4, and SOX2 was determined by immunohistochemistry using a tissue microarray analysis. Results Patients with strong expression of NANOG had significantly lower disease-free survival (DFS) and overall survival rates than those with weak expression of NANOG (P = 0.004 and 0.033, respectively). In contrast, patients with strong expression of KLF4 had better DFS (P = 0.014). Conclusions Strong expression of NANOG is an indicator of a poor prognosis for breast cancer patients, whereas KLF4 is a favorable prognostic indicator. Our results suggest that NANOG stimulates the growth and metastasis of breast cancer cells, whereas KLF4 inhibits these processes.
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Keywords {🔍}

cancer, article, breast, google, scholar, pubmed, nanog, cas, expression, klf, stem, cell, cells, prognostic, oct, toyama, privacy, cookies, content, research, factors, patients, access, data, publish, search, nagata, sox, prostate, liu, oncogene, information, log, journal, takuya, shimada, sekine, hori, fukuoka, pluripotent, ips, prognosis, strong, survival, discover, embryonic, science, pluripotency, biol, central,

Topics {✒️}

month download article/chapter stem/progenitor cell properties ips cell-inducing factors breast cancer cells pluripotent stem cells related subjects full article pdf breast cancer patients human somatic cells privacy choices/manage cookies nat cell biol clin cancer res prostate cancer resistance prognostic significance ips cell favorable prognostic indicator tissue microarray analysis breast cancer breast cancer 21 european economic area adult fibroblast cultures curr opin genet barbosa-morais nl valuable technical assistance independent data sets conditions privacy policy article nagata chromatin remodeling factors stem cells benign prostate hyperplasia brm/brg1 expression gene-expression signature accepting optional cookies c-myc amplification article log check access instant access poor prognosis author information authors pluripotency marker oct3/4 journal finder publish cancer res shigeaki sawada mouse embryonic article cite prostate cancer breast carcinoma breast tumours prognostic biomarkers prognostic relevance

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         description:Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. The aim of the present study was to examine the relationship between the expression of iPS cell-inducing factors and the prognosis of breast cancer patients. In 100 breast cancer patients, the expression of c-MYC, KLF4, NANOG, OCT4, and SOX2 was determined by immunohistochemistry using a tissue microarray analysis. Patients with strong expression of NANOG had significantly lower disease-free survival (DFS) and overall survival rates than those with weak expression of NANOG (P = 0.004 and 0.033, respectively). In contrast, patients with strong expression of KLF4 had better DFS (P = 0.014). Strong expression of NANOG is an indicator of a poor prognosis for breast cancer patients, whereas KLF4 is a favorable prognostic indicator. Our results suggest that NANOG stimulates the growth and metastasis of breast cancer cells, whereas KLF4 inhibits these processes.
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