We are analyzing https://link.springer.com/article/10.1007/s12265-020-09994-3.

Title:
The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease | Journal of Cardiovascular Translational Research
Description:
Chronic inflammation drives the development of atherosclerosis. Despite optimal treatment of classical cardiovascular risk factors, a substantial portion of the population has elevated inflammatory biomarkers and develops atherosclerosis-related complications, indicating that a residual inflammatory risk drives atherosclerotic cardiovascular disease in these patients. Additional anti-inflammatory therapeutic strategies are therefore required. The co-stimulatory molecule CD40 and its ligand CD40L (CD154) have a central role in the regulation of the inflammatory response during the development of atherosclerosis by modulating the interaction between immune cells and between immune cells and non-immune cells. In this review, we discuss the role of the CD40-CD40L dyad in atherosclerosis, and we discuss recent studies on the therapeutic potential of novel CD40-CD40L targeting strategies in cardiovascular medicine.
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Keywords {🔍}

pubmed, google, scholar, cas, cells, atherosclerosis, cardiovascular, inflammatory, cdl, interactions, atherosclerotic, central, coronary, patients, cell, journal, ligand, immune, disease, inflammation, cdcdl, activation, cdtraf, levels, scdl, risk, soluble, therapeutic, role, potential, research, acute, endothelial, cvd, inhibition, plaque, studies, protein, reduced, clinical, interaction, macrophages, vascular, expression, seijkens, elevated, heart, thrombosis, traf, article,

Topics {✒️}

nf-kappab/mir-125b axis monocyte/macrophage-driven inflammation high-sensitivity c-reactive protein restoring nf-kappab1 activation oxidized low-density lipoprotein beta3 integrin--dependent mechanism inhibit cd40-driven inflammation blocking cd40-traf6 signaling blocking cd40-traf6 interactions st-segment elevated mi elevated high-sensitive crp antibody anti-m7 blocks cd40 single-nucleotide polymorphisms circulating platelet-leukocyte aggregates anti-inflammatory agent colchicine small molecule-mediated inhibition deficient cd40-traf6 signaling maintaining protective host-defense evidence-based pharmaceutical targets sterile lps-induced sepsis genius-ii project ‘generating high-risk patient populations cd40l-cd40-traf6 axis thioglycolate-induced peritoneal macrophages anti-mac-1 hampered clearance molecular therapy--nucleic acids cd40-cd40 ligand signaling require long-term treatment van den berg develops atherosclerosis-related complications classical cd40l-mac1 interactions article download pdf tumour necrosis factor post-translational regulatory mechanisms cd40–cd40l–traf cascade chinese case-control study mediates leukocyte recruitment anti-cd40 sirna therapy c4bp-cd40 interactions occur promoting monocyte adhesion promising anti-inflammatory strategy cd40-cd40l targeting strategies heath-shock protein acute coronary syndrome-results immune checkpoint proteins cd40-traf2/3/5 interactions regulate cd40-traf2/3/5-mediated immunity platelet-leukocyte aggregates [3] long-term clinical outcomes single-nucleotide polymorphism

Questions {❓}

CD40 in coronary artery disease: a matter of macrophages?
HSP 70 and atherosclerosis--protector or activator?
Is there more than C-reactive protein and fibrinogen?
SCD40(L): A Biomarker for Atherosclerotic CVD?

Schema {🗺️}

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         headline:The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease
         description:Chronic inflammation drives the development of atherosclerosis. Despite optimal treatment of classical cardiovascular risk factors, a substantial portion of the population has elevated inflammatory biomarkers and develops atherosclerosis-related complications, indicating that a residual inflammatory risk drives atherosclerotic cardiovascular disease in these patients. Additional anti-inflammatory therapeutic strategies are therefore required. The co-stimulatory molecule CD40 and its ligand CD40L (CD154) have a central role in the regulation of the inflammatory response during the development of atherosclerosis by modulating the interaction between immune cells and between immune cells and non-immune cells. In this review, we discuss the role of the CD40-CD40L dyad in atherosclerosis, and we discuss recent studies on the therapeutic potential of novel CD40-CD40L targeting strategies in cardiovascular medicine.
         datePublished:2020-03-28T00:00:00Z
         dateModified:2020-03-28T00:00:00Z
         pageStart:13
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            Atherosclerosis
            Inflammation
            Immune checkpoint proteins
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            CD40L
            Cardiology
            Human Genetics
            Biomedical Engineering and Bioengineering
            Biomedicine
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      headline:The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease
      description:Chronic inflammation drives the development of atherosclerosis. Despite optimal treatment of classical cardiovascular risk factors, a substantial portion of the population has elevated inflammatory biomarkers and develops atherosclerosis-related complications, indicating that a residual inflammatory risk drives atherosclerotic cardiovascular disease in these patients. Additional anti-inflammatory therapeutic strategies are therefore required. The co-stimulatory molecule CD40 and its ligand CD40L (CD154) have a central role in the regulation of the inflammatory response during the development of atherosclerosis by modulating the interaction between immune cells and between immune cells and non-immune cells. In this review, we discuss the role of the CD40-CD40L dyad in atherosclerosis, and we discuss recent studies on the therapeutic potential of novel CD40-CD40L targeting strategies in cardiovascular medicine.
      datePublished:2020-03-28T00:00:00Z
      dateModified:2020-03-28T00:00:00Z
      pageStart:13
      pageEnd:22
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s12265-020-09994-3
      keywords:
         Cardiovascular disease
         Atherosclerosis
         Inflammation
         Immune checkpoint proteins
         CD40
         CD40L
         Cardiology
         Human Genetics
         Biomedical Engineering and Bioengineering
         Biomedicine
         general
         Medicine/Public Health
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               name:Department of Pathology, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
               type:PostalAddress
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      name:Esther Lutgens
      affiliation:
            name:University of Amsterdam
            address:
               name:Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
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            address:
               name:Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian’s University, Munich, Germany
               type:PostalAddress
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      name:Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
      name:Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
      name:Department of Pathology, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
      name:Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
      name:Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian’s University, Munich, Germany
      name:German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany
      name:Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands

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