We are analyzing https://link.springer.com/article/10.1007/s12032-014-0304-1.

Title:
Expression of HIF-1α and CAIX in nasopharyngeal carcinoma and their correlation with patients’ prognosis | Medical Oncology
Description:
This study investigates the expression of hypoxia-inducible factor-l alpha (HIF-1α) and carbonic anhydrase IX (CAIX) in nasopharyngeal carcinoma (NPC) tissues and their correlation with clinicopathological features and prognosis in NPC patients. The expression of HIF-1α and CAIX proteins was detected by immunohistochemical staining in 129 samples of NPC and 20 samples of chronic nasopharyngitis. The correlations between the expression of these two proteins and clinicopathological features and prognosis were evaluated in NPC patients. Our results showed that the positive expression rates of HIF-1α and CAIX proteins in NPC were significantly higher than those in chronic nasopharyngitis (both P < 0.01). In addition, high HIF-1α protein expression was correlated with lymph node metastasis and advanced clinical stage for NPC patients (both P < 0.01), whereas there were no findings of correlations between CAIX protein expression and gender, age, T stage, node involvement and clinical stage (all P > 0.05). The Spearman analysis indicated that HIF-1α was positively correlated with CAIX expression (r = 0.249, P = 0.004). HIF-1α and CAIX co-expression was associated with the poor overall survival (OS), progression-free survival (PFS), loco-regional relapse-free survival (LRRFS) and distant metastasis-free survival (DMFS) in NPC patients (P = 0.017, P = 0.022, P = 0.033, and P = 0.017, respectively). Multivariate analysis showed that the positive expression of CAIX protein was an independent prognostic factor for PFS, LRRFS and DMFS. In conclusion, overexpression of HIF-1α and CAIX might be involved in the carcinogenesis and development of NPC and they were associated with patients’ poor prognosis.
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Keywords {🔍}

caix, hifα, expression, npc, patients, cancer, article, pubmed, google, scholar, prognosis, survival, cas, carcinoma, positive, metastasis, tumor, stage, poor, cell, staining, clinical, analysis, nasopharyngeal, radiotherapy, factor, hifalpha, carbonic, found, table, anhydrase, showed, significantly, pfs, lrrfs, distant, dmfs, prognostic, overexpression, hypoxiainducible, correlated, expressions, protein, age, node, locoregional, head, neck, hypoxia, cells,

Topics {✒️}

loco-regional relapse-free survival endogenous hypoxia-related markers zihuang li & dong yang cell–cell adhesion disruption loco-regional relapse-free article download pdf hypoxia-inducible factor-1alpha promoted epithelial-mesenchymal transition hydrating cell-generated co2 hif-1α transcription complex early-stage laryngeal carcinoma concurrent cisplatin–radiotherapy compared hif-1α signaling pathway distant metastasis-free survival /ebp-delta regulates vegf npc paraffin-embedded tissues hypoxia-inducible factor hypoxia-inducible factor-1 carbonic anhydrase ix loco-regional relapse inhibiting e-cadherin full access human breast carcinoma independent prognostic factor transcription factor twist gene targeted therapy hypoxia-inducible factors privacy choices/manage cookies key adhesion molecule hif-1alpha promotes metastasis kaplan–meier curves hif-1α high expression nasopharyngeal carcinoma cases weak hif-1alpha expression glioma cell metastasis improve therapeutic efficiency hypoxia-inducible activity carbonic anhydrase-9 expression disease-free survival cell signaling technology hypoxia-inducible expression npc patient outcome independent prognostic indicator nat cell biol negative hif-1α expression kaplan–meier analyses kaplan–meier method hypoxia-induced invasion exp cell res soft tissue sarcoma

Schema {🗺️}

WebPage:
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         headline:Expression of HIF-1α and CAIX in nasopharyngeal carcinoma and their correlation with patients’ prognosis
         description:This study investigates the expression of hypoxia-inducible factor-l alpha (HIF-1α) and carbonic anhydrase IX (CAIX) in nasopharyngeal carcinoma (NPC) tissues and their correlation with clinicopathological features and prognosis in NPC patients. The expression of HIF-1α and CAIX proteins was detected by immunohistochemical staining in 129 samples of NPC and 20 samples of chronic nasopharyngitis. The correlations between the expression of these two proteins and clinicopathological features and prognosis were evaluated in NPC patients. Our results showed that the positive expression rates of HIF-1α and CAIX proteins in NPC were significantly higher than those in chronic nasopharyngitis (both P < 0.01). In addition, high HIF-1α protein expression was correlated with lymph node metastasis and advanced clinical stage for NPC patients (both P < 0.01), whereas there were no findings of correlations between CAIX protein expression and gender, age, T stage, node involvement and clinical stage (all P > 0.05). The Spearman analysis indicated that HIF-1α was positively correlated with CAIX expression (r = 0.249, P = 0.004). HIF-1α and CAIX co-expression was associated with the poor overall survival (OS), progression-free survival (PFS), loco-regional relapse-free survival (LRRFS) and distant metastasis-free survival (DMFS) in NPC patients (P = 0.017, P = 0.022, P = 0.033, and P = 0.017, respectively). Multivariate analysis showed that the positive expression of CAIX protein was an independent prognostic factor for PFS, LRRFS and DMFS. In conclusion, overexpression of HIF-1α and CAIX might be involved in the carcinogenesis and development of NPC and they were associated with patients’ poor prognosis.
         datePublished:2014-11-07T00:00:00Z
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            Hypoxia-inducible factor-1 alpha
            Carbonic anhydrase IX
            Prognosis
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            Hematology
            Pathology
            Internal Medicine
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      headline:Expression of HIF-1α and CAIX in nasopharyngeal carcinoma and their correlation with patients’ prognosis
      description:This study investigates the expression of hypoxia-inducible factor-l alpha (HIF-1α) and carbonic anhydrase IX (CAIX) in nasopharyngeal carcinoma (NPC) tissues and their correlation with clinicopathological features and prognosis in NPC patients. The expression of HIF-1α and CAIX proteins was detected by immunohistochemical staining in 129 samples of NPC and 20 samples of chronic nasopharyngitis. The correlations between the expression of these two proteins and clinicopathological features and prognosis were evaluated in NPC patients. Our results showed that the positive expression rates of HIF-1α and CAIX proteins in NPC were significantly higher than those in chronic nasopharyngitis (both P < 0.01). In addition, high HIF-1α protein expression was correlated with lymph node metastasis and advanced clinical stage for NPC patients (both P < 0.01), whereas there were no findings of correlations between CAIX protein expression and gender, age, T stage, node involvement and clinical stage (all P > 0.05). The Spearman analysis indicated that HIF-1α was positively correlated with CAIX expression (r = 0.249, P = 0.004). HIF-1α and CAIX co-expression was associated with the poor overall survival (OS), progression-free survival (PFS), loco-regional relapse-free survival (LRRFS) and distant metastasis-free survival (DMFS) in NPC patients (P = 0.017, P = 0.022, P = 0.033, and P = 0.017, respectively). Multivariate analysis showed that the positive expression of CAIX protein was an independent prognostic factor for PFS, LRRFS and DMFS. In conclusion, overexpression of HIF-1α and CAIX might be involved in the carcinogenesis and development of NPC and they were associated with patients’ poor prognosis.
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         Hypoxia-inducible factor-1 alpha
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         Prognosis
         Oncology
         Hematology
         Pathology
         Internal Medicine
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