We are analyzing https://link.springer.com/article/10.1007/s12026-015-8693-6.

Title:
Molecular studies of lupus nephritis kidneys | Immunologic Research
Description:
Lupus nephritis is a devastating complication of systemic lupus erythematosus (SLE) for which current therapies are insufficiently effective. Histologic evaluation of renal biopsies is a poor predictor of therapeutic response or outcome. Integrated immunologic, genomic and proteomic approaches may yield new insights into disease pathogenesis and thereby improve therapeutic strategies for lupus nephritis. Given the lack of sequential biopsies from humans, it also remains essential to study informative animal models of disease. Cross-species analyses can identify cells or pathways that are relevant to human disease and can be further studied in mouse models. Using a systems biology approach in which we compare molecular data from kidneys of three different mouse models of lupus nephritis with data from human lupus biopsies, we have found that inflammatory events escalate rapidly around the time of proteinuria onset. This is followed by hypoxia and metabolic stress, and by tubular and endothelial dysfunction. The failure of complete reversal of these abnormalities may increase the sensitivity of the kidney to further insult. We further found that renal macrophages and dendritic cells are key players in lupus nephritis both in mouse models and humans and that macrophages display a hybrid molecular profile that reflects incomplete resolution of inflammation and excessive tissue remodeling. Finally, our studies have suggested several new biomarkers for disease stage that can now be tested longitudinally in human SLE patients.
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Keywords {🔍}

pubmed, article, google, scholar, cas, lupus, nephritis, central, kidney, renal, immunol, systemic, dendritic, erythematosus, disease, cells, bethunaickan, human, int, murine, macrophages, davidson, models, research, berthier, mice, arthritis, mouse, glomerulonephritis, nephrol, ramanujam, huang, liu, cell, zhang, sle, biomarkers, rheumatol, clin, schiffer, wang, macrophage, injury, privacy, cookies, content, data, access, rheum, subsets,

Topics {✒️}

month download article/chapter rna-related antigens due experimental renal inflammation—part freire-de-lima cg cross-species analyses single-cell rna sequencing kidney ischemia-reperfusion injury mononuclear phagocyte system full article pdf systemic lupus erythematosus shared regulatory networks lupus nephritis kidneys proliferative lupus nephritis privacy choices/manage cookies hybrid molecular profile lupus research institute comparative transcriptional profiling severe lupus nephritis lupus nephritis flare human lupus nephritis t-cell responses human macrophage activation murine lupus nephritis lupus nephritis flares sle nephritis reveals immune complex formation tlr7 gene duplication musculoskeletal diseases human renal tissue related subjects transcriptional regulatory pathways compare molecular data article davidson excessive tissue remodeling de fijter jw lupher ml jr rose ce jr stage-specific genes local macrophage proliferation physiol renal physiol curr opin rheumatol european economic area systems biology approach short term administration ctla4ig prevents initiation anti-phospholipid syndrome holdsworth sr hamilton-williams ee gene-expression profiles chemokine receptors ccr2

Questions {❓}

The kidney biopsy in lupus nephritis: is it still relevant?

Schema {🗺️}

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         description:Lupus nephritis is a devastating complication of systemic lupus erythematosus (SLE) for which current therapies are insufficiently effective. Histologic evaluation of renal biopsies is a poor predictor of therapeutic response or outcome. Integrated immunologic, genomic and proteomic approaches may yield new insights into disease pathogenesis and thereby improve therapeutic strategies for lupus nephritis. Given the lack of sequential biopsies from humans, it also remains essential to study informative animal models of disease. Cross-species analyses can identify cells or pathways that are relevant to human disease and can be further studied in mouse models. Using a systems biology approach in which we compare molecular data from kidneys of three different mouse models of lupus nephritis with data from human lupus biopsies, we have found that inflammatory events escalate rapidly around the time of proteinuria onset. This is followed by hypoxia and metabolic stress, and by tubular and endothelial dysfunction. The failure of complete reversal of these abnormalities may increase the sensitivity of the kidney to further insult. We further found that renal macrophages and dendritic cells are key players in lupus nephritis both in mouse models and humans and that macrophages display a hybrid molecular profile that reflects incomplete resolution of inflammation and excessive tissue remodeling. Finally, our studies have suggested several new biomarkers for disease stage that can now be tested longitudinally in human SLE patients.
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