We are analyzing https://link.springer.com/article/10.1007/s12013-022-01087-z.

Title:
The different facets of heme-oxygenase 1 in innate and adaptive immunity | Cell Biochemistry and Biophysics
Description:
Heme oxygenase (HO) enzymes are responsible for the main oxidative step in heme degradation, generating equimolar amounts of free iron, biliverdin and carbon monoxide. HO-1 is induced as a crucial stress response protein, playing protective roles in physiologic and pathological conditions, due to its antioxidant, anti-apoptotic and anti-inflammatory effects. The mechanisms behind HO-1-mediated protection are being explored by different studies, affecting cell fate through multiple ways, such as reduction in intracellular levels of heme and ROS, transcriptional regulation, and through its byproducts generation. In this review we focus on the interplay between HO-1 and immune-related signaling pathways, which culminate in the activation of transcription factors important in immune responses and inflammation. We also discuss the dual interaction of HO-1 and inflammatory mediators that govern resolution and tissue damage. We highlight the dichotomy of HO-1 in innate and adaptive immune cells development and activation in different disease contexts. Finally, we address different known anti-inflammatory pharmaceuticals that are now being described to modulate HO-1, and the possible contribution of HO-1 in their anti-inflammatory effects.
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Keywords {🔍}

pubmed, article, google, scholar, cas, heme, oxygenase, central, cell, cells, immunol, expression, activation, jul, kim, lee, biol, pmid, human, mol, oct, med, dec, carbon, inflammation, feb, role, res, immunity, monoxide, response, signaling, httpsdoiorg, jun, nov, wang, physiol, immune, induction, choi, inflammatory, chem, inhibits, zhang, antiinflammatory, jan, chen, httpsdoiorgjimmunol, regulatory, innate,

Topics {✒️}

tlr2/myd88/c-src/nadph oxidase pathway month download article/chapter il-1β-stimulated human astrocytes tnf-alpha-mediated airway inflammation p38 mapk-creb/atf1 signaling transforming growth factor-β carbon monoxide-releasing compounds innate-mediated proinflammatory cytokine azole-based antifungal drugs silica-induced lung injury nf-kappab signaling pathway tnf/tnfr family members p38-dependent signaling pathway granulocyte-monocyte progenitors accepted manuscript version heme oxygenase-1/carbon monoxide puncture-induced sepsis model heme oxygenase-1-dependant pathway nf-e2-related factor 2 tgf-beta1 stimulates ho-1 modulating ifn-beta production immune-related signaling pathways lps-stimulated human monocytes anti-inflammatory cytokine expression cisplatin-induced auditory damage nf-κb signaling pathways heme-regulated eif2α kinase tnfr1-dependent oxidative stress reactive oxygen species cellular signaling molecule indomethacin-induced renal damage bilirubin-induced reactive microglia clp-induced septic mice heme oxygenase-1-mediated induction carbon monoxide generated neutrophil cell-free system nf-kappab rela phosphorylation steroidal anti-inflammatory drugs foxp3-mediated immune suppression superoxide-producing nadph oxidase regulating ros-induced trafficking article cell biochemistry suggesting iron-catalysed reactions pro-inflammatory cytokines nitric oxide production heme oxygenase-1 attenuates th17/treg cell differentiation hematopoietic stem/progenitor cells liver ischemia/reperfusion injury anti-inflammatory host factor

Questions {❓}

Biliverdin inhibits hepatitis C virus nonstructural 3/4A protease activity: mechanism for the antiviral effects of heme oxygenase?
Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells?
How many transcription factors does it take to turn on the heme oxygenase-1 gene?
Immunoregulatory effects of HO-1: how does it work?
The problem of curcumin and its bioavailability: could its gastrointestinal influence contribute to its overall health-enhancing effects?

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         description:Heme oxygenase (HO) enzymes are responsible for the main oxidative step in heme degradation, generating equimolar amounts of free iron, biliverdin and carbon monoxide. HO-1 is induced as a crucial stress response protein, playing protective roles in physiologic and pathological conditions, due to its antioxidant, anti-apoptotic and anti-inflammatory effects. The mechanisms behind HO-1-mediated protection are being explored by different studies, affecting cell fate through multiple ways, such as reduction in intracellular levels of heme and ROS, transcriptional regulation, and through its byproducts generation. In this review we focus on the interplay between HO-1 and immune-related signaling pathways, which culminate in the activation of transcription factors important in immune responses and inflammation. We also discuss the dual interaction of HO-1 and inflammatory mediators that govern resolution and tissue damage. We highlight the dichotomy of HO-1 in innate and adaptive immune cells development and activation in different disease contexts. Finally, we address different known anti-inflammatory pharmaceuticals that are now being described to modulate HO-1, and the possible contribution of HO-1 in their anti-inflammatory effects.
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         general
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