We are analyzing https://link.springer.com/article/10.1007/s11427-018-9371-4.

Title:
An overview of energy and metabolic regulation | Science China Life Sciences
Description:
The physiology and behaviors related to energy balance are monitored by the nervous and humoral systems. Because of the difficulty in treating diabetes and obesity, elucidating the energy balance mechanism and identifying critical targets for treatment are important research goals. Therefore, the purpose of this article is to describe energy regulation by the central nervous system (CNS) and peripheral humoral pathway. Homeostasis and rewarding are the basis of CNS regulation. Anorexigenic or orexigenic effects reflect the activities of the POMC/CART or NPY/AgRP neurons within the hypothalamus. Neurotransmitters have roles in food intake, and responsive brain nuclei have different functions related to food intake, glucose monitoring, reward processing. Peripheral gut- or adipose-derived hormones are the major source of peripheral humoral regulation systems. Nutrients or metabolites and gut microbiota affect metabolism via a discrete pathway. We also review the role of peripheral organs, the liver, adipose tissue, and skeletal muscle in peripheral regulation. We discuss these topics and how the body regulates metabolism.
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Keywords {🔍}

pubmed, article, google, scholar, cas, central, food, intake, brain, physiol, receptor, neurons, diabetes, energy, obesity, neurosci, hypothalamic, nucleus, regulation, receptors, metab, role, behav, system, body, mice, signaling, effects, weight, leptin, rats, control, feeding, glucose, clin, dopamine, nature, cell, homeostasis, metabolism, endocrinol, res, rev, wang, reward, sci, insulin, activation, adiponectin, metabolic,

Topics {✒️}

short-chain fatty-acid binding month download article/chapter g-protein-coupled receptor ffar2 central nervous system branched-chain amino acids min gong & ligang zhou glucose-inhibited central neurons npy/agrp neurons agrp/npy neurons amp-activated protein kinase central melanocortin system gut-brain axis due appetite-stimulating peptide hormone nucleus tractus solitarius gut-brain neural circuits adipose-derived hormones transforming growth factor-β metagenome-wide association study neurotensin-1 receptor agonist neuro-endocrine system arcuate agrp neurons responsive brain nuclei post-cessation weight gain serotonin 2c receptor leptin receptor-expressing cells full article pdf brain serotonin system high-palatability food preference neuroendocrine arcuate nucleus chronic central infusion corticotropin-releasing hormone arcuate pomc neurons protein-coupled receptor male sprague-dawley rats china life sci medial amygdalar nucleus cart gene ventral tegmental area diet-induced insulin resistance diet-induced obese mice growth hormone secretion important research goals serotonin controlling feeding fatty-acid oxidation enhance human hedonic gut-brain axis diet-induced obese rats hepatic β-oxidation urocortin1-induced anorexia mesolimbic dopamine system

Questions {❓}

Can we selectively reduce appetite for energy-dense foods?
Serotonergic and histaminergic mechanisms involved in intralipid drinking?
To ingest or rest?
Beta-Hydroxybutyrate: a signaling metabolite in starvation response?

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