We are analyzing https://link.springer.com/article/10.1007/s11033-008-9395-0.

Title:
Response of the ABCG2 promoter in T47D cells and BeWo cells to sex hormone treatment | Molecular Biology Reports
Description:
The aim of this study was to elucidate the effects of sex hormones on activity of the ABCG2 promoter in different cell lines. T47D cells and BeWo cells were used as models for ABCG2-expressing cell lines, and luciferase assays using ABCG2 promoter–luciferase constructs were performed. It was shown that progesterone increased the response of the ABCG2 promoter in T47D cells but not in BeWo cells. On the other hand, estradiol had no effect on response of the ABCG2 promoter in either cell line. However, response of the ABCG2 promoter was enhanced by overexpression of ERα in both T47D cells and BeWo cells. T47D cells had higher sensitivity to ERα than did BeWo cells. Furthermore, it was shown that the inductive effect of progesterone on the ABCG2 promoter was inhibited by addition of RU486 or mithramycin A. Therefore, it was thought that the ABCG2 promoter responded to stimulation of the progesterone receptor (PR)-Sp1 pathway in T47D cells. Furthermore, progesterone suppressed the response of the ABCG2 promoter by changing the expression levels of PR-A and PR-B in BeWo cells. These findings suggested that there are differences between cell lines in the regulation mechanism of ABCG2 expression by sex hormone treatment.
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Keywords {🔍}

article, pubmed, google, scholar, cas, cells, abcg, expression, promoter, human, bewo, progesterone, resistance, cancer, cell, response, sex, regulation, access, protein, drug, ross, breast, gene, biol, privacy, cookies, content, hormone, yasuda, itagaki, iseki, receptor, multidrug, mol, function, publish, search, hirano, transporter, transporters, sci, estrogen, res, data, information, log, journal, research, treatment,

Topics {✒️}

month download article/chapter bailey-dell kj takeshi hirano & ken iseki multidrug resistance transporter fk506-binding immunophilin fkbp51 estrogen-mediated post transcriptional drug-selected cancer cells phorbol ester-induced activation related subjects abcg2 promoter–luciferase constructs full article pdf sex hormone treatment abcg2-expressing cell lines tissue-specific expression multidrug resistance mediated multidrug resistance transporters atp binding cassette privacy choices/manage cookies human choriocarcinoma cells bcrp/abcg2 expression article yasuda doyle la estrogen receptor expression normal human tissues human trophoblast differentiation abcg2 transport protein human progesterone receptor abcg2 promoter responded mammalian haem transport european economic area naturally occurring variants blood–brain barriers endometrial adenocarcinoma cells eukaryotic transcription factors reproductive functions estrogen receptors alpha progesterone regulates transcription check access instant access estrogen response element conditions privacy policy article log alternative promoter usage accepting optional cookies attenuates progestin responsiveness article cite transcription factors sp1 abcg2 expression main content log ligand-specific regulation

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         description:The aim of this study was to elucidate the effects of sex hormones on activity of the ABCG2 promoter in different cell lines. T47D cells and BeWo cells were used as models for ABCG2-expressing cell lines, and luciferase assays using ABCG2 promoter–luciferase constructs were performed. It was shown that progesterone increased the response of the ABCG2 promoter in T47D cells but not in BeWo cells. On the other hand, estradiol had no effect on response of the ABCG2 promoter in either cell line. However, response of the ABCG2 promoter was enhanced by overexpression of ERα in both T47D cells and BeWo cells. T47D cells had higher sensitivity to ERα than did BeWo cells. Furthermore, it was shown that the inductive effect of progesterone on the ABCG2 promoter was inhibited by addition of RU486 or mithramycin A. Therefore, it was thought that the ABCG2 promoter responded to stimulation of the progesterone receptor (PR)-Sp1 pathway in T47D cells. Furthermore, progesterone suppressed the response of the ABCG2 promoter by changing the expression levels of PR-A and PR-B in BeWo cells. These findings suggested that there are differences between cell lines in the regulation mechanism of ABCG2 expression by sex hormone treatment.
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