We are analyzing https://link.springer.com/article/10.1007/s10787-018-0489-6.

Title:
Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer | Inflammopharmacology
Description:
We examined the expression of major inflammatory genes, cyclooxygenase-1 and 2 (COX1, COX2) and arachidonate 5-lipoxygenase (ALOX5) in 1090 tumor samples of invasive breast cancer from The Cancer Genome Atlas (TCGA). Mean cyclooxygenase expression (COX1 + COX2) ranked in the upper 99th percentile of all 20,531 genes and surprisingly, the mean expression of COX1 was more than tenfold higher than COX2. Highly significant correlations were observed between COX2 with eight tumor-promoting genes (EGR2, IL6, RGS2, B3GNT5, SGK1, SLC2A3, SFRP1 and ETS2) and between ALOX5 and ten tumor promoter genes (CD33, MYOF1, NLRP1, GAB3, CD4, IFR8, CYTH4, BTK, FGR, CD37). Expression of CYP19A1 (aromatase) was significantly correlated with COX2, but only in tumors positive for ER, PR and HER2. Tumor-promoting genes correlated with the expression of COX1, COX2, and ALOX5 are known to effectively increase mitogenesis, mutagenesis, angiogenesis, cell survival, immunosuppression and metastasis in the pathogenesis of breast cancer.
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Keywords {🔍}

pubmed, cancer, google, scholar, article, cas, breast, central, expression, cox, cyclooxygenase, tumor, cells, res, gene, cell, human, harris, lipoxygenase, inflammation, prostaglandin, genes, metastasis, access, growth, liu, data, receptor, role, biol, factor, zhang, wang, privacy, cookies, content, aromatase, sci, nature, nat, rev, publish, research, search, inflammogenesis, genome, open, signaling, mol, med,

Topics {✒️}

anti-csf-1r antibody reveals c-fms proto-oncogene product month download article/chapter colony-stimulating factor 1 tyrosine kinase signaling epstein–barr virus infection article inflammopharmacology aims lipoxygenase gene expression gene expression patterns ohio state university acyl-coa synthetase 4 rna-seq data tumor-promoting genes correlated cox-2/pge2 upregulation contributes full article pdf related subjects die krankhaften geschwulste privacy choices/manage cookies national cancer institute breast carcinoma cells tumor-promoting genes normalizing egfr expression induces slug expression prostate cancer cells breast tumor microenvironment human breast tumor invasive breast cancer human breast cancer breast cancer subtypes breast cancer malignancy human breast tumours feline sarcoma virus colorectal cancer prevention breast cancer biology 5-lipoxygenase converging functions 11β-prostaglandin f2α european economic area major inflammatory genes upper 99th percentile highly significant correlations effectively increase mitogenesis prognostic immunity markers abou-issa hm glut3 glucose transporters accurate transcript quantification børresen-dale al arachidonic acid metabolism mammary epithelial subpopulations perou cm bioactive metabolite catalyzed

Questions {❓}

Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow?
Williams CS, DuBois RN (1996) Prostaglandin endoperoxide synthase: why two isoforms?

Schema {🗺️}

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      headline:Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer
      description:We examined the expression of major inflammatory genes, cyclooxygenase-1 and 2 (COX1, COX2) and arachidonate 5-lipoxygenase (ALOX5) in 1090 tumor samples of invasive breast cancer from The Cancer Genome Atlas (TCGA). Mean cyclooxygenase expression (COX1 + COX2) ranked in the upper 99th percentile of all 20,531 genes and surprisingly, the mean expression of COX1 was more than tenfold higher than COX2. Highly significant correlations were observed between COX2 with eight tumor-promoting genes (EGR2, IL6, RGS2, B3GNT5, SGK1, SLC2A3, SFRP1 and ETS2) and between ALOX5 and ten tumor promoter genes (CD33, MYOF1, NLRP1, GAB3, CD4, IFR8, CYTH4, BTK, FGR, CD37). Expression of CYP19A1 (aromatase) was significantly correlated with COX2, but only in tumors positive for ER, PR and HER2. Tumor-promoting genes correlated with the expression of COX1, COX2, and ALOX5 are known to effectively increase mitogenesis, mutagenesis, angiogenesis, cell survival, immunosuppression and metastasis in the pathogenesis of breast cancer.
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         Lipoxygenase
         RNA sequence data
         Pharmacology/Toxicology
         Immunology
         Rheumatology
         Gastroenterology
         Dermatology
         Allergology
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