We are analyzing https://link.springer.com/article/10.1007/s10555-025-10266-2.

Title:
Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy | Cancer and Metastasis Reviews
Description:
In recent years, increasing evidence has shown that metals play important roles in both innate and adaptive immunity. An emerging concept of metalloimmunotherapy has been proposed, which may accelerate the development of immunotherapy for cancers. Here, we discuss how metals affect T cell function through different signaling pathways. Metals impact the fate of T cells, including their activation, proliferation, cytotoxicity, and differentiation. Most importantly, metals also participate in mitochondrial operation by regulating energy production and reactive oxygen species homeostasis in T cells. We also identified the metal-based mutual effects between tumor cells and T cells in the tumor microenvironment. Overall, the antitumor effect of T cells can be improved by targeting metal metabolism and metalloimmunotherapy, which will be a step forward in the treatment of cancers. 
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

pubmed, article, google, scholar, cell, central, cells, cancer, journal, immunology, nature, activation, calcium, tumor, immune, research, immunity, signaling, fau, antitumor, function, sci, mitochondrial, immunotherapy, microenvironment, molecular, zhang, chen, human, ferroptosis, iron, wang, sun, metabolism, differentiation, responses, magnesium, zinc, therapy, cellular, liu, enhances, nfat, proc, natl, acad, biology, metabolic, effector, expression,

Topics {✒️}

post-operative immuno-adjuvant therapy pd-1/pd-l1 inhibitors month download article/chapter photodynamic immunotherapy-initiated ferroptosis cyclic dinucleotide-manganese particles proton-pump inhibitors suppress metal-based mutual effects augments pro-inflammatory cytokines important contributing factor orai1-mediated calcium entry pd-l1 degradation cas-hku joint laboratory clustering-dependent signaling switch store-operated calcium channel mineralized metal-organic framework promoting ldha-mediated ferroptosis efficient t-cell activation functionally impaired interleukin-2-inducible vdac-facilitated calcium transport graft-versus-tumor effect facilitate store-operated ca epstein-barr virus infection enhances anti-leukemia efficacy cell anti-tumor immunity proximal t-cell signaling cell receptor-induced ca potentiate cancer radio-immunotherapy immune checkpoint inhibitors manganese superoxide dismutase activation-induced cell death altered mitochondrial respiration t-cell-receptor-activated pd-1 checkpoint blockade regulates ifn-gamma trpm7 channel activity tumor infiltrating cd8+ tumor microenvironment enhances full article pdf hypoxia regulates expression metabolite bh4 controls calcium-nfat transcriptional signalling intracellular iron homeostasis pd1 blockade enhances pd-1 blockade therapy nf-kappab dynamically immunosuppressive agent caerulomycin zn2+ ion links promotes intratumoral cd8+ privacy choices/manage cookies distinctive calcium response

Questions {❓}

(2024) Activity of potassium channels in CD8+ T lymphocytes: diagnostic and prognostic biomarker in ovarian cancer?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy
         description:In recent years, increasing evidence has shown that metals play important roles in both innate and adaptive immunity. An emerging concept of metalloimmunotherapy has been proposed, which may accelerate the development of immunotherapy for cancers. Here, we discuss how metals affect T cell function through different signaling pathways. Metals impact the fate of T cells, including their activation, proliferation, cytotoxicity, and differentiation. Most importantly, metals also participate in mitochondrial operation by regulating energy production and reactive oxygen species homeostasis in T cells. We also identified the metal-based mutual effects between tumor cells and T cells in the tumor microenvironment. Overall, the antitumor effect of T cells can be improved by targeting metal metabolism and metalloimmunotherapy, which will be a step forward in the treatment of cancers.
         datePublished:2025-04-29T00:00:00Z
         dateModified:2025-04-29T00:00:00Z
         pageStart:1
         pageEnd:22
         sameAs:https://doi.org/10.1007/s10555-025-10266-2
         keywords:
            T cell
            Metal ion
            Immunomodulation
            Metalloimmunotherapy
            Tumor microenvironment
            Cancer Research
            Oncology
            Biomedicine
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-025-10266-2/MediaObjects/10555_2025_10266_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-025-10266-2/MediaObjects/10555_2025_10266_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-025-10266-2/MediaObjects/10555_2025_10266_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-025-10266-2/MediaObjects/10555_2025_10266_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-025-10266-2/MediaObjects/10555_2025_10266_Fig5_HTML.png
         isPartOf:
            name:Cancer and Metastasis Reviews
            issn:
               1573-7233
            volumeNumber:44
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Peiyun Liao
               affiliation:
                     name:Zhujiang Hospital, Southern Medical University
                     address:
                        name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ying Zhou
               affiliation:
                     name:The University of Hong Kong
                     address:
                        name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yingqi Qiu
               affiliation:
                     name:Zhujiang Hospital, Southern Medical University
                     address:
                        name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rong Hu
               affiliation:
                     name:Zhujiang Hospital, Southern Medical University
                     address:
                        name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hongyan Li
               affiliation:
                     name:The University of Hong Kong
                     address:
                        name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hongzhe Sun
               affiliation:
                     name:The University of Hong Kong
                     address:
                        name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Yuhua Li
               affiliation:
                     name:Zhujiang Hospital, Southern Medical University
                     address:
                        name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
                     name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
                     address:
                        name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China
                        type:PostalAddress
                     type:Organization
                     name:Guangdong Engineering Research Center of Precision Immune Cell Therapy Technology, Zhujiang Hospital
                     address:
                        name:Guangdong Engineering Research Center of Precision Immune Cell Therapy Technology, Zhujiang Hospital, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy
      description:In recent years, increasing evidence has shown that metals play important roles in both innate and adaptive immunity. An emerging concept of metalloimmunotherapy has been proposed, which may accelerate the development of immunotherapy for cancers. Here, we discuss how metals affect T cell function through different signaling pathways. Metals impact the fate of T cells, including their activation, proliferation, cytotoxicity, and differentiation. Most importantly, metals also participate in mitochondrial operation by regulating energy production and reactive oxygen species homeostasis in T cells. We also identified the metal-based mutual effects between tumor cells and T cells in the tumor microenvironment. Overall, the antitumor effect of T cells can be improved by targeting metal metabolism and metalloimmunotherapy, which will be a step forward in the treatment of cancers.
      datePublished:2025-04-29T00:00:00Z
      dateModified:2025-04-29T00:00:00Z
      pageStart:1
      pageEnd:22
      sameAs:https://doi.org/10.1007/s10555-025-10266-2
      keywords:
         T cell
         Metal ion
         Immunomodulation
         Metalloimmunotherapy
         Tumor microenvironment
         Cancer Research
         Oncology
         Biomedicine
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-025-10266-2/MediaObjects/10555_2025_10266_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-025-10266-2/MediaObjects/10555_2025_10266_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-025-10266-2/MediaObjects/10555_2025_10266_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-025-10266-2/MediaObjects/10555_2025_10266_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-025-10266-2/MediaObjects/10555_2025_10266_Fig5_HTML.png
      isPartOf:
         name:Cancer and Metastasis Reviews
         issn:
            1573-7233
         volumeNumber:44
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Peiyun Liao
            affiliation:
                  name:Zhujiang Hospital, Southern Medical University
                  address:
                     name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ying Zhou
            affiliation:
                  name:The University of Hong Kong
                  address:
                     name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yingqi Qiu
            affiliation:
                  name:Zhujiang Hospital, Southern Medical University
                  address:
                     name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rong Hu
            affiliation:
                  name:Zhujiang Hospital, Southern Medical University
                  address:
                     name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hongyan Li
            affiliation:
                  name:The University of Hong Kong
                  address:
                     name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hongzhe Sun
            affiliation:
                  name:The University of Hong Kong
                  address:
                     name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Yuhua Li
            affiliation:
                  name:Zhujiang Hospital, Southern Medical University
                  address:
                     name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
                  address:
                     name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:Guangdong Engineering Research Center of Precision Immune Cell Therapy Technology, Zhujiang Hospital
                  address:
                     name:Guangdong Engineering Research Center of Precision Immune Cell Therapy Technology, Zhujiang Hospital, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cancer and Metastasis Reviews
      issn:
         1573-7233
      volumeNumber:44
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Zhujiang Hospital, Southern Medical University
      address:
         name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
         type:PostalAddress
      name:The University of Hong Kong
      address:
         name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
         type:PostalAddress
      name:Zhujiang Hospital, Southern Medical University
      address:
         name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
         type:PostalAddress
      name:Zhujiang Hospital, Southern Medical University
      address:
         name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
         type:PostalAddress
      name:The University of Hong Kong
      address:
         name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
         type:PostalAddress
      name:The University of Hong Kong
      address:
         name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
         type:PostalAddress
      name:Zhujiang Hospital, Southern Medical University
      address:
         name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
         type:PostalAddress
      name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
      address:
         name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China
         type:PostalAddress
      name:Guangdong Engineering Research Center of Precision Immune Cell Therapy Technology, Zhujiang Hospital
      address:
         name:Guangdong Engineering Research Center of Precision Immune Cell Therapy Technology, Zhujiang Hospital, Guangzhou, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Peiyun Liao
      affiliation:
            name:Zhujiang Hospital, Southern Medical University
            address:
               name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Ying Zhou
      affiliation:
            name:The University of Hong Kong
            address:
               name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
               type:PostalAddress
            type:Organization
      name:Yingqi Qiu
      affiliation:
            name:Zhujiang Hospital, Southern Medical University
            address:
               name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Rong Hu
      affiliation:
            name:Zhujiang Hospital, Southern Medical University
            address:
               name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Hongyan Li
      affiliation:
            name:The University of Hong Kong
            address:
               name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
               type:PostalAddress
            type:Organization
      name:Hongzhe Sun
      affiliation:
            name:The University of Hong Kong
            address:
               name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Yuhua Li
      affiliation:
            name:Zhujiang Hospital, Southern Medical University
            address:
               name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
               type:PostalAddress
            type:Organization
            name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
            address:
               name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China
               type:PostalAddress
            type:Organization
            name:Guangdong Engineering Research Center of Precision Immune Cell Therapy Technology, Zhujiang Hospital
            address:
               name:Guangdong Engineering Research Center of Precision Immune Cell Therapy Technology, Zhujiang Hospital, Guangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
      name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
      name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
      name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
      name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
      name:Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics On Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
      name:Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
      name:Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China
      name:Guangdong Engineering Research Center of Precision Immune Cell Therapy Technology, Zhujiang Hospital, Guangzhou, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(588)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.72s.

LINK . SPRINGER . COM {}