We are analyzing https://link.springer.com/article/10.1007/s10555-022-10023-9.

Title:
Heterogeneity and tumor evolution reflected in liquid biopsy in metastatic breast cancer patients: a review | Cancer and Metastasis Reviews
Description:
Breast cancer is a spatially and temporally dynamic disease in which differently evolving genetic clones are responsible for progression and clinical outcome. We review tumor heterogeneity and clonal evolution from studies comparing primary tumors and metastasis and discuss plasma circulating tumor DNA as a powerful real-time approach for monitoring the clonal landscape of breast cancer during treatment and recurrence. We found only a few early studies exploring clonal evolution and heterogeneity through analysis of multiregional tissue biopsies of different progression steps in comparison with circulating tumor DNA (ctDNA) from blood plasma. The model of linear progression seemed to be more often reported than the model of parallel progression. The results show complex routes to metastasis, however, and plasma most often reflected metastasis more than primary tumor. The described patterns of evolution and the polyclonal nature of breast cancer have clinical consequences and should be considered during patient diagnosis and treatment selection. Current studies focusing on the relevance of clonal evolution in the clinical setting illustrate the role of liquid biopsy as a noninvasive biomarker for monitoring clonal progression and response to treatment. In the clinical setting, circulating tumor DNA may be an ideal support for tumor biopsies to characterize the genetic landscape of the metastatic disease and to improve longitudinal monitoring of disease dynamics and treatment effectiveness through detection of residual tumor after resection, relapse, or metastasis within a particular patient.
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Keywords {🔍}

cancer, breast, article, pubmed, google, scholar, cas, heterogeneity, tumor, evolution, clinical, dna, metastatic, circulating, nature, central, journal, clonal, metastasis, sequencing, medicine, progression, research, primary, odense, liquid, review, analysis, genetic, reviews, biopsy, plasma, treatment, tumour, cancers, oncology, plos, denmark, privacy, cookies, content, information, patients, kavan, disease, monitoring, landscape, biopsies, current, access,

Topics {✒️}

month download article/chapter powerful real-time approach tissue microarray-based study related subjects copy number aberrations hildebrandt & mads thomassen full article pdf intra-tumour heterogeneity single-cell genome sequencing positron emission tomography circulating tumour dna cell-free dna primary breast cancers metastatic breast cancer circulating tumor dna privacy choices/manage cookies measuring clonal evolution breast cancer research nature publishing grou human breast cancer advanced cancer patients overcome tumor heterogeneity branched evolution revealed staging breast cancer tumor mutation load pathologic tumour size article cancer tumor evolution reflected breast cancer progression breast cancer metastasis digital breast tomosynthesis monitoring clonal progression breast cancer resistance circulating tumor cells national cancer institute article kavan linear genome evolution clinical cancer research nature reviews cancer single nucleotide resolution circulating cancer cells current studies focusing treatment selection multiple intratumoral assays breast cancer recurrence review tumor heterogeneity single-cell sequencing multiregional tissue biopsies personalized response monitoring immunohistochemical marker expression

Questions {❓}

Intra-tumour heterogeneity: A looking glass for cancer?

Schema {🗺️}

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         headline:Heterogeneity and tumor evolution reflected in liquid biopsy in metastatic breast cancer patients: a review
         description:Breast cancer is a spatially and temporally dynamic disease in which differently evolving genetic clones are responsible for progression and clinical outcome. We review tumor heterogeneity and clonal evolution from studies comparing primary tumors and metastasis and discuss plasma circulating tumor DNA as a powerful real-time approach for monitoring the clonal landscape of breast cancer during treatment and recurrence. We found only a few early studies exploring clonal evolution and heterogeneity through analysis of multiregional tissue biopsies of different progression steps in comparison with circulating tumor DNA (ctDNA) from blood plasma. The model of linear progression seemed to be more often reported than the model of parallel progression. The results show complex routes to metastasis, however, and plasma most often reflected metastasis more than primary tumor. The described patterns of evolution and the polyclonal nature of breast cancer have clinical consequences and should be considered during patient diagnosis and treatment selection. Current studies focusing on the relevance of clonal evolution in the clinical setting illustrate the role of liquid biopsy as a noninvasive biomarker for monitoring clonal progression and response to treatment. In the clinical setting, circulating tumor DNA may be an ideal support for tumor biopsies to characterize the genetic landscape of the metastatic disease and to improve longitudinal monitoring of disease dynamics and treatment effectiveness through detection of residual tumor after resection, relapse, or metastasis within a particular patient.
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