We are analyzing https://link.springer.com/article/10.1007/s10522-017-9685-9.

Title:
Sirtuins, a promising target in slowing down the ageing process | Biogerontology
Description:
Ageing is a plastic process and can be successfully modulated by some biomedical approaches or pharmaceutics. In this manner it is possible to delay or even prevent some age-related pathologies. There are some defined interventions, which give promising results in animal models or even in human studies, resulting in lifespan elongation or healthspan improvement. One of the most promising targets for anti-ageing approaches are proteins belonging to the sirtuin family. Sirtuins were originally discovered as transcription repressors in yeast, however, nowadays they are known to occur in bacteria and eukaryotes (including mammals). In humans the family consists of seven members (SIRT1-7) that possess either mono-ADP ribosyltransferase or deacetylase activity. It is believed that sirtuins play key role during cell response to a variety of stresses, such as oxidative or genotoxic stress and are crucial for cell metabolism. Although some data put in question direct involvement of sirtuins in extending human lifespan, it was documented that proper lifestyle including physical activity and diet can influence healthspan via increasing the level of sirtuins. The search for an activator of sirtuins is one of the most extensive and robust topic of research. Some hopes are put on natural compounds, including curcumin. In this review we summarize the involvement and usefulness of sirtuins in anti-ageing interventions and discuss the potential role of curcumin in sirtuins regulation.
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Keywords {🔍}

sirt, pubmed, google, scholar, article, cas, activity, central, sirtuins, senescence, cell, curcumin, dna, level, cells, ageing, sirtuin, damage, mice, stress, aging, expression, human, pathway, role, nad, exercise, lifespan, oxidative, repair, activation, cellular, shown, effects, wang, restriction, increased, biol, protein, sir, regulation, ampk, effect, signaling, mitochondrial, proteins, zhang, involved, gene, muscle,

Topics {✒️}

3-hydroxy-3-methyl-glutaryl-coa synthase responsible ewa sikora & anna bielak-zmijewska good anti-senescence/anti-ageing targets igf1r/pi3k/akt survival pathway tumor suppressors mir-125a-5p apoe/ldlr-double knockout mice anti-inflammatory molecule-multifaceted roles article download pdf c-terminal regulatory domain acute gentamicin-induced nephrotoxicity hyperglycemia-induced endothelial dysfunction antagonizes pml-induced acetylation n-terminal lysine residues activated erk/s6k1 signaling post-translational protein modification cardio-cerebral vascular disease undergo time-dependent deterioration amp-activated protein kinase diet-induced aortic stiffness p53-induced growth arrest full-length sirt3 resides inhibiting rnapoli-dependent transcription ste20-related adaptor protein dna-dependent protein kinase suppressing nf-κb signaling h2o2-induced cellular senescence akt/mtor signaling pathway 2′-o-acetyl-adp-ribose 1-o-acetyl-adp-ribose possesses anti-ageing function histone methyl-transferase suv39h1 h2o2-induced oxidative stress long-term moderate exercise injury-induced neointima formation full size image age-related endothelial dysfunction doxorubicin-induced premature senescence inhibiting akt/mtor pathway vascular smooth muscle beneficial anti-pathological factor human epidermal keratinocytes circadian/daily cycle due inhibiting mtor/s6k1 pathway anna bielak-zmijewska overactivated insulin/igf1 signaling energy deprivation-dependent apoptosis inhibiting insulin/igf-1 signaling long-term calorie restriction insulin/igf-1 signaling pathway 5-aminoimidazole-4-carboxamide riboside

Questions {❓}

Cava E, Fontana L (2013) Will calorie restriction work in humans?
Coughlan KA, Valentine RJ, Ruderman NB, Saha AK (2014) AMPK activation: a therapeutic target for type 2 diabetes?
Ingram DK, Roth GS (2015) Calorie restriction mimetics: can you have your cake and eat it, too?
Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L (2015) Interventions to slow aging in humans: are we ready?
Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, Ido Y (2010) AMPK and SIRT1: a long-standing partnership?
Zhang J (2003) Are poly(ADP-rybosyl)ation by PARP-1 and deacetylation by Sir2 linked?

Schema {🗺️}

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      name:Laboratory of Molecular Bases of Aging, Department of Biochemistry, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, Poland
      name:Laboratory of Molecular Bases of Aging, Department of Biochemistry, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, Poland

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