
NCBI . NLM . NIH . GOV {
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Title[redir]:
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity - PMC
Description:
AMP-activated protein kinase (AMPK) is a metabolic fuel gauge conserved along the evolutionary scale in eukaryotes that senses changes in the intracellular AMP/ATP ratio1. The interest in AMPK has recently been raised by evidence showing that AMPK ...
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Keywords {🔍}
sirt, pgcα, doi, ampk, aicar, pubmed, google, scholar, activity, protein, deacetylation, expression, hrs, acetylation, pmc, control, mitochondrial, myotubes, nad, forward, kinase, muscle, cells, reverse, nature, article, oxidation, free, cell, levels, gene, nadnadh, energy, treated, consumption, acid, metabolic, ratio, activation, foxo, treatment, data, pgcalpha, metabolism, exercise, increase, nampt, biol, effects, phosphorylation,
Topics {✒️}
ampk activator 5-aminoimidazole-4-carboxamide-1-beta-d-riboside amp-activated/snf1 protein kinases estrogen-related receptor-α anti-ampkα anti-phospho-ampkα transcriptional coactivator pgc-1{alpha} flag-ha-tagged pgc-1α exercise-induced pgc-1α deacetylation aicar-induced pgc-1α deacetylation ampk-induced sirt1-mediated deacetylation amp-activated protein kinase nad-dependent histone deacetylase 2-kb mpgc-1α reporter pmc beta search mildly activated pgc-1α anti-phospho acetylcoa carboxylase fast post-translational events hexokinase-dependant assay kit pgc-1α r13 mutant induced pgc-1α deacetylation protein g-sepharose resuspended basal pgc-1α activity anti-diabetic drugs rosiglitazone anti-ha monoclonal antibodies pgc-1α transcriptional activity leucine-rich interaction motif pgc-1α positively autoregulates flag-r13-pgc-1α intracellular amp/atp ratio1 pgc-1α 2a mutant 2a-pgc-1α mutant5 glucose-activated gene expression decreased pgc-1α acetylation flag-ha-pgc-1α triggers pgc-1α deacetylation protein-g-conjugated beads exercise-induced gene expression pgc-1α acetylation levels 1 ha-pgc-1α plasmid alters pgc-1α deacetylation ampk activates pgc-1α pgc-1α phosphorylation mutant diet-induced metabolic disorders anti-actin goat antibodies decrease pgc-1α acetylation pgc-1α 2a mutation monitored pgc-1α activity quantitative real-time pcr modulate pgc-1α acetylation examined pgc-1α acetylation test pgc-1α acetylation
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