We are analyzing https://link.springer.com/article/10.1007/s10495-024-02022-8.

Title:
Emerging druggable targets for immune checkpoint modulation in cancer immunotherapy: the iceberg lies beneath the surface | Apoptosis
Description:
The immune system serves as a fundamental defender against the initiation and progression of cancer. Failure of the immune system augments immunosuppressive action that leading to cancer manifestation. This immunosuppressive effect causes from significant alterations in immune checkpoint expression associated with tumoral progression. The tumor microenvironment promotes immune escape mechanisms that further amplifying immunosuppressive actions. Notably, substantial targeting of immune checkpoints has been pragmatic in the advancement of cancer research. This study highlights a comprehensive review of emerging druggable targets aimed at modulating immune checkpoint co-inhibitory as well as co-stimulatory molecules in response to immune system activation. This modulation has prompted to the development of newer therapeutic insights, eventually inducing immunogenic cell death through immunomodulatory actions. The study emphasizes the role of immune checkpoints in immunogenic regulation of cancer pathogenesis and explores potential therapeutic avenues in cancer immunotherapy. Graphical Abstract Modulation of Immunosuppressive and Immunostimulatory pathways of immune checkpoints in cancer immunotherapy
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Keywords {🔍}

pubmed, article, google, scholar, cas, central, cancer, immune, cell, immunotherapy, immunol, checkpoint, cells, zhang, httpsdoiorgs, wang, chen, front, oncol, targeting, res, tumor, patients, clin, httpsdoiorgfimmu, liu, therapy, med, mol, clinical, role, zhao, receptor, zhou, expression, tcell, lee, carcinoma, phase, httpsdoiorg, kim, rev, sci, immunity, vista, targets, antibodies, receptors, signaling, immunother,

Topics {✒️}

bifunctional anti-pd-l1/tgf-βrii agent bifunctional anti-pd-l1/tgfβrii agent tumour-induced t-cell desertification anti-pd-1/l1 treatment-naïve head protein-coupled receptor-mediated signaling anti-ox40-mediated tumor rejection tumor-expressed b7-h3 mediates month download article/chapter immune receptors b7-h3/cd276 pd-1/pd-l1 blockade monotherapy tumor-antigen-binding bispecific antibodies support cd8 + t-cell proliferation anti- pd-l1 antibody targeting tgf-β isoforms cd4+ t-cell differentiation b-cell-based immunotherapy pd-1/pd-l1 pathway enhanced anti-tumor activity immune-related adverse events regulating anti-tumor immunity pd-1/pd-l1 blockade membrane b7-h3 expression cd8 t-cell densities tim-3/gal-9/bat3 pathway immune checkpoints pd-l1 exert tumor-suppressive action article apoptosis aims antitumor t-cell functions human t-cell response multi-lineage immune checkpoint cd8 t-cell responses treg cell-based therapies pd-1/pd-l1 + tumors b7-h3/cd276 ifn-γ-dependent cytotoxicity pd/1-pd-ls checkpoint full article pdf exhausted tumor-infiltrating cd8+ anti- tim-3 antibody tumor-targeted 4-1bb agonists targeting b7-h3 dual anti-pd lag-3 + tumor infiltrating lymphocytes 1/tgf-β inhibitors phase ia/ib study related subjects immune checkpoint molecule emerging druggable targets soluble b7-h3 b7-h3 inhibits

Questions {❓}

Musielak B, Kocik J, Skalniak L, Magiera-Mularz K, Sala D, Czub M, Stec M, Siedlar M, Holak TA, Plewka J (2019) CA-170 - a potent small-molecule PD-L1 inhibitor or not?
Wikenheiser DJ, Stumhofer JS (2016) ICOS Co-stimulation: friend or foe?

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         description:The immune system serves as a fundamental defender against the initiation and progression of cancer. Failure of the immune system augments immunosuppressive action that leading to cancer manifestation. This immunosuppressive effect causes from significant alterations in immune checkpoint expression associated with tumoral progression. The tumor microenvironment promotes immune escape mechanisms that further amplifying immunosuppressive actions. Notably, substantial targeting of immune checkpoints has been pragmatic in the advancement of cancer research. This study highlights a comprehensive review of emerging druggable targets aimed at modulating immune checkpoint co-inhibitory as well as co-stimulatory molecules in response to immune system activation. This modulation has prompted to the development of newer therapeutic insights, eventually inducing immunogenic cell death through immunomodulatory actions. The study emphasizes the role of immune checkpoints in immunogenic regulation of cancer pathogenesis and explores potential therapeutic avenues in cancer immunotherapy. Modulation of Immunosuppressive and Immunostimulatory pathways of immune checkpoints in cancer immunotherapy
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      description:The immune system serves as a fundamental defender against the initiation and progression of cancer. Failure of the immune system augments immunosuppressive action that leading to cancer manifestation. This immunosuppressive effect causes from significant alterations in immune checkpoint expression associated with tumoral progression. The tumor microenvironment promotes immune escape mechanisms that further amplifying immunosuppressive actions. Notably, substantial targeting of immune checkpoints has been pragmatic in the advancement of cancer research. This study highlights a comprehensive review of emerging druggable targets aimed at modulating immune checkpoint co-inhibitory as well as co-stimulatory molecules in response to immune system activation. This modulation has prompted to the development of newer therapeutic insights, eventually inducing immunogenic cell death through immunomodulatory actions. The study emphasizes the role of immune checkpoints in immunogenic regulation of cancer pathogenesis and explores potential therapeutic avenues in cancer immunotherapy. Modulation of Immunosuppressive and Immunostimulatory pathways of immune checkpoints in cancer immunotherapy
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