
NCBI . NLM . NIH . GOV {
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Title[redir]:
The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment - PMC
Description:
Williams et al. show that 4-BB and LAG-3, previously identified as EGR2 targets from in vitro T cell anergy studies, are sufficient to identify dysfunctional tumor antigenāspecific CD8+ T cells in the tumor microenvironment. These markers ...
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Keywords {š}
cells, tumor, cell, tils, expression, bblag, til, lag, doi, google, scholar, day, pubmed, fig, egr, tumors, pmc, population, mice, article, free, dysfunctional, analysis, experiments, microenvironment, receptors, gene, independent, analyzed, sorted, vitro, vivo, cancer, antigenspecific, time, subpopulations, data, expressed, populations, gajewski, coexpression, production, ifnγ, chronic, bsiy, inoculation, phenotype, immunol, immune, isolated,
Topics {āļø}
h-2kb/siy-specific cd8+ tils tumor-specific h-2kb/siy+ suggests h-2kbārestricted siy epitope twyman-saint victor h-2kb/siyāspecific cd8 h-2kb/siyā cd8+ tils h-2kb/siy+ cd8+ tils antiālag-3/antiā4-1bb restored include pd-l1āpd-1 interactions anti-ctla-4 + antiāpd-l1 tumor-draining lymph node anti-pd-l1-based immunotherapies klrg-1hiil-7rαlo populations showed h-2kb/siy+ cells expressed cd8+4-1bb+lag-3+ tils express t-bet transcription factor plate-bound anti-cd3 tumor antigenāspecific til pmc beta search antigen-specific cd8+ tils rank-rank hypergeometric overlap blocking antiālag-3 mab tumor antigenāspecific cd8+ tumor antigen-specific cd8 short-lived effector cd8+ h-2kb/siyā population agonistic antiā4-1bb mab rank-rank hypergeometric test anti-lag-3 acts synergistically egr2-driven transcriptional program egr2-gfphi cd8+ tils pmc copyright notice layering ficoll-hypaque beneath h-2kb/siy analysis peasy-flox vector adjacent tumor-specific cd8+ tils identify tumor-specific exhausted h-2kbārestricted lcmv-derived gp33-41 epitope cd8+ t-cell recruitment klrg-1hiil-7rαlo population h-2kb/siyā cells h-2kb/siy+ cells circumventing lcmv-induced downregulation cd8+4-1bbālag-3āpd-1ā cells bonferroni post-hoc test antiālag-3 mab treatment short-lived effector cells antiāpd-1-based therapies ficoll-hypaque gradient centrifugation
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- https://scholar.google.com/scholar_lookup?journal=Trends%20Immunol.&title=Tolerance%20and%20exhaustion:%20defining%20mechanisms%20of%20T%20cell%20dysfunction&volume=35&publication_year=2014&pages=51-60&pmid=24210163&doi=10.1016/j.it.2013.10.001&'s total income per month
- https://doi.org/10.1016/j.immuni.2016.07.011's total income per month
- How much does https://scholar.google.com/scholar_lookup?journal=Immunity.&title=Tumor-specific%20T%20cell%20dysfunction%20is%20a%20dynamic%20antigen-driven%20differentiation%20program%20initiated%20early%20during%20tumorigenesis&volume=45&publication_year=2016&pages=389-401&pmid=27521269&doi=10.1016/j.immuni.2016.07.011& make?
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- See how much https://scholar.google.com/scholar_lookup?journal=Annu.%20Rev.%20Immunol.&title=T%20cell%20anergy&volume=21&publication_year=2003&pages=305-334&pmid=12471050&doi=10.1146/annurev.immunol.21.120601.141110& makes per month
- What's the total monthly financial gain of https://doi.org/10.1101/SQB.1989.054.01.072?
- How much does https://scholar.google.com/scholar_lookup?journal=Cold%20Spring%20Harb.%20Symp.%20Quant.%20Biol.&title=T-cell%20clonal%20anergy&volume=54&publication_year=1989&pages=605-610&pmid=2534840&doi=10.1101/SQB.1989.054.01.072& make?
- What's the profit of https://doi.org/10.1101/gr.1239303?
- How much does https://scholar.google.com/scholar_lookup?journal=Genome%20Res.&title=Cytoscape:%20a%20software%20environment%20for%20integrated%20models%20of%20biomolecular%20interaction%20networks&volume=13&publication_year=2003&pages=2498-2504&pmid=14597658&doi=10.1101/gr.1239303& make?
- What are the total earnings of https://doi.org/10.1016/j.coi.2015.03.002?
- What's the financial outcome of https://scholar.google.com/scholar_lookup?journal=Curr.%20Opin.%20Immunol.&title=New%20insights%20into%20type%20I%20interferon%20and%20the%20immunopathogenesis%20of%20persistent%20viral%20infections&volume=34&publication_year=2015&pages=91-98&pmid=25771184&doi=10.1016/j.coi.2015.03.002&?
- Financial intake of https://doi.org/10.1016/S1074-7613(02)00480-6
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Immunity.&title=Increasing%20tumor%20antigen%20expression%20overcomes%20%E2%80%9Cignorance%E2%80%9D%20to%20solid%20tumors%20via%20crosspresentation%20by%20bone%20marrow-derived%20stromal%20cells&volume=17&publication_year=2002&pages=737-747&pmid=12479820&doi=10.1016/S1074-7613(02)00480-6&?
- https://doi.org/10.1126/scitranslmed.3006504 income
- How much does https://scholar.google.com/scholar_lookup?journal=Sci.%20Transl.%20Med.&title=Up-regulation%20of%20PD-L1,%20IDO,%20and%20T(regs)%20in%20the%20melanoma%20tumor%20microenvironment%20is%20driven%20by%20CD8(+)%20T%20cells&volume=5&publication_year=2013&pages=200ra116&pmid=23986400&doi=10.1126/scitranslmed.3006504& rake in every month?
- https://doi.org/10.1186/2051-1426-2-3 income
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- Financial intake of https://doi.org/10.4161/jkst.23952
- How much does https://scholar.google.com/scholar_lookup?journal=JAK-STAT.&title=Egr2%20and%20Egr3%20are%20the%20unique%20regulators%20for%20systemic%20autoimmunity&volume=2&publication_year=2013&pages=e23952&pmid=24058814&doi=10.4161/jkst.23952& make?
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- How much money does https://doi.org/10.1146/annurev-immunol-031210-101324 make?
- See how much https://scholar.google.com/scholar_lookup?journal=Annu.%20Rev.%20Immunol.&title=Natural%20innate%20and%20adaptive%20immunity%20to%20cancer&volume=29&publication_year=2011&pages=235-271&pmid=21219185&doi=10.1146/annurev-immunol-031210-101324& makes per month
- How much profit does https://doi.org/10.4049/jimmunol.1600589 generate?
- https://scholar.google.com/scholar_lookup?journal=J.%20Immunol.&title=Molecular%20profile%20of%20tumor-specific%20CD8+%20T%20cell%20hypofunction%20in%20a%20transplantable%20murine%20cancer%20model&volume=197&publication_year=2016&pages=1477-1488&pmid=27371726&doi=10.4049/jimmunol.1600589&'s financial summary
- What are the earnings of https://doi.org/10.1038/nri3862?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Nat.%20Rev.%20Immunol.&title=Molecular%20and%20cellular%20insights%20into%20T%20cell%20exhaustion&volume=15&publication_year=2015&pages=486-499&pmid=26205583&doi=10.1038/nri3862& bring in?
- How much profit does https://doi.org/10.1016/j.immuni.2007.09.006 make?
- Revenue of https://scholar.google.com/scholar_lookup?journal=Immunity.&title=Molecular%20signature%20of%20CD8+%20T%20cell%20exhaustion%20during%20chronic%20viral%20infection&volume=27&publication_year=2007&pages=670-684&pmid=17950003&doi=10.1016/j.immuni.2007.09.006&
- How much revenue does https://doi.org/10.1038/bjc.2014.416 bring in?
- How much cash flow does https://scholar.google.com/scholar_lookup?journal=Br.%20J.%20Cancer.&title=PD-1+%20CD8+%20T%20cells%20are%20exhausted%20in%20tumours%20and%20functional%20in%20draining%20lymph%20nodes%20of%20colorectal%20cancer%20patients&volume=111&publication_year=2014&pages=1391-1399&pmid=25093496&doi=10.1038/bjc.2014.416& have monthly?
- What's the financial gain of https://doi.org/10.1084/jem.188.12.2205?
- How much money does https://scholar.google.com/scholar_lookup?journal=J.%20Exp.%20Med.&title=Viral%20immune%20evasion%20due%20to%20persistence%20of%20activated%20T%20cells%20without%20effector%20function&volume=188&publication_year=1998&pages=2205-2213&pmid=9858507&doi=10.1084/jem.188.12.2205& generate?
- How much income is https://doi.org/10.1038/ni1394 earning monthly?
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- Financial intake of https://doi.org/10.1182/blood-2009-03-206672
- https://scholar.google.com/scholar_lookup?journal=Blood.&title=PD-1/PD-L1%20interactions%20inhibit%20antitumor%20immune%20responses%20in%20a%20murine%20acute%20myeloid%20leukemia%20model&volume=114&publication_year=2009&pages=1545-1552&pmid=19417208&doi=10.1182/blood-2009-03-206672&'s financial summary
- What's https://doi.org/10.1084/jem.20120342's gross income?
- How much does https://scholar.google.com/scholar_lookup?journal=J.%20Exp.%20Med.&title=Transcriptional%20regulator%20early%20growth%20response%20gene%202%20(Egr2)%20is%20required%20for%20T%20cell%20anergy%20in%20vitro%20and%20in%20vivo&volume=209&publication_year=2012&pages=2157-2163&pmid=23129747&doi=10.1084/jem.20120342& make?
- Discover the revenue of https://doi.org/10.1016/j.molimm.2013.03.006
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Mol.%20Immunol.&title=Egr2-dependent%20gene%20expression%20profiling%20and%20ChIP-Seq%20reveal%20novel%20biologic%20targets%20in%20T%20cell%20anergy&volume=55&publication_year=2013&pages=283-291&pmid=23548837&doi=10.1016/j.molimm.2013.03.006&?
- See how much https://github.com/ncbi makes per month
- Discover the revenue of https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323
- How much income is https://www.nlm.nih.gov/web_policies.html earning monthly?
- Check the income stats for https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office
- What's https://www.hhs.gov/vulnerability-disclosure-policy/index.html's gross income?
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